Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm > Pharm 1 Final > Flashcards

Pharm 1 Final Flashcards

1
Q

Malaria and P. falciparum Treatment

A

DOC Chloroquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Amebiasis/ protozoa

A

DOC Metronidazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Helminths

A

DOC Mebendazole: microtubule destruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Ectoparasites, helminths, arthropods

A

Ivermectin

DOC ectoparasites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MOA: inhibits DNA, transcription, and nuclear acid function

A

Cyclophosphamide: ALL, Lymphoma, brest, Ovarian, Lung, Multiple myeloma, sarcasm and CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

MOA: competivitly inhibits dihydrofolate reductase

A

Methotrexate: DMARD, AI dz (immunosuppressant)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

SE: Red urine

A

“Rub” pigment = doxorubicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Broadest anti-neoplastic

A

doxorubicin -> anti-biotic like agent, antracylcine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

neoplastic with cardio toxicity

A

doxorubicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Microtubule inhibitor (neoplasm)

A

pacletaxel –> joint pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q 
estrogen antagonist (selective competitor)-> early breast CA
agonist in uterine tissue
A

Tamoxifen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Breast and ovarian CA treatment

A

Pacletaxel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Inactivates Plasmodium (polymerizes heme)

A

chloroquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

intensifies release of GABA

A

affects SM of worms–> ivermectin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Na/K/Cl in Thick ascending loop of hence

its with low GFR (kid dz)/HTN emergences

A

furcosimide: loop diuretic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Na.cl in Distal tubule

Increases osmolality w/in nephron(water retained

A

hydrochlorothiazide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q 
potassium-sparing
inhibits aldosterone (competitively) in heart, arterial, and kidneys
A

spironolactone: acne tx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Inhibits angiotensin converting enzyme in lungs (less angiotensin II)
Use for DM, HF with diuretic and digitalis

A

ACE: lisinopril

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

CCB (L-type) of Sm, prevents bundle of his, AV node from firing
Tx?

A

Diltiazem (Class IV)

tx HTN, angina, arrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Beta 1 and 2 inhibitor (NO DM or asthma)
tx?
lipid soluble

A

Propranolol (Class II)
tx: HTN, angina,
Phase 4 dipolar)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Blocks beta 1/antagonizes catecholamines

Tx? DM and asthmatics

A

Metoprolol: (Class II)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Rate Control

A

Class II (BB), IV (CCB), V (digoxin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Rhythm Control

A

Class Ia (Na/K open), Ic (Na open) and III (LKr inhibitor)

24
Q

Beta 1 blocker, higher mortality except silent ischemia

Neg chronotropic and inotropic effects

A

Atenolol

tx: angina, HTN

25
Q

alpha 1 blockage activity (blood vessels)
tx?
Grapefruit juice

A

Carvedilol (alpha and beta)

tx: MI, HTN, CHF, angina

26
Q

Decreases preload relax SM, vasodilation
immediate relief
TX?

A

nitroglycerine (stimulate NO receptors)

DOC angina, HF

27
Q

antioxidant to NO, vasodilator
TX?
Lupus like syndrome –> ANA+

A

Hydralazine

Tx: HF (africa americans), angina, anterior dilator

28
Q

Na/K-ATPase inhibitor
Slows AV node
Cardiac glycoside

A

Digoxin (Class V)
tx: CHF and SVT, arrhythmias
slim margin of safety (blood sample

29
Q

IKr channel blocker (phase 3 repolar)
Tx?
Adverse RXN?

A

Amiodarone: Class 3
Tx: arrhyythmias (vent supra vent), atach/afib,
SE:corneal deposits, thyroid d/o (like T4), photosensitivity, pull. fibrosis.

30
Q

Blocks open Na/K channel (slow phase 0)
Tx?
SE?

A

quinidine (Class 1a)
Tx: fib, attach, anti-parasite (malaria)
SE: TTP, torsades, cinchonism

31
Q

Guanosine analog
decrease viral replication via DNA rep.
BBB?

A

Acyclovir: Herpes (HSV, and VZV)
Treat: HSV meningitis encephalitis

32
Q

Block P2Y12 of ADP on platelet surface (no GPIIb/IIIa complex)

A

Clopidogrel: anti-thrombotic
platelet lifetime
interest with everything

33
Q

HMG-CoA reductase inhibitor
First SE?
Red yeast, niacin, alcohol, SJW, sweet orange

A

Atorvastatin: ASCVD, hyperchol (decrease LDL)
Muscle soreness
Upreg. LDL receptors (liver)

34
Q

Prevents absorption of dietary and biliary cholerstol (enterohepatic circulation and chylomicron assembly

A 
Ezetimibe
stain intolerance, still upreg, LDL receptors, decrease plasma LDL
fecal clearance (80%)
35
Q

anti-neoplastic resistant CA

A

melanoma, brain CA, Renal cell CA

36
Q

MC open-angle glaucoma treatment
Prostaglandin analog
SE?

A

latanoprost –> increase aqueous outflow

SE: iris pig., ocular irration

37
Q

Topical MRSA and Impetigo Tx

A

Mupirocin

inhibits bac protéine synthesis

38
Q

Increases permeability by binding to ergosterol in fungus

Pre-treat?

A

Amphoterricin B

–> anti-his, anti-paretics, cortico

39
Q

Blocks formation of ergosterol (static)

Tx?

A

Floconazole (not with warfarin)

Candida of mucous mem.

40
Q

Leukotrine modifier, (LTD4) which inhibits lipogenase

A

Montelakast

Asthma/COPD

41
Q

Phosphodiesterase inhibitor, relax SM

Limited clinical use

A

Theophylline

hyperstimulation

42
Q

Bind to bac ribosome irrversibly binds
MC used amino glycoside
tx?

A

Gentamicin: bac conjuncivitis, broad spectrum (nephron/ototoxicity)

43
Q

beta lactam and lactase inhibitor

Treats:

A

Augmentin(amoxicillin clavulinate)
Enterococci (b. fragilis), OM, UTI, sinusitis, bronchitis (endocard=IV)
most serve AID (c. diff)

44
Q

binds to PBP which inhibits cell wall synthesis

A

Cephalexin

No enterococcus, pen allergy

45
Q

Macrolide, bind 50s rib subunit

Tx:

A

Azithromycin

atypical resp. pathogens (legion, chlym, mycoplasma)

46
Q

Binds 30s bac rib,
Tx?
SE:

A

Doxy=Resp/sinusitis
Tetracycline= MRSA
H. Inf, Rickettsiae, atypical rest path.
SE: photosens./teeth discoloration

47
Q

Prevents folic acid inhibition

A

Sulfamethoxazole: given with TMP

Best tx for UTI

48
Q

inhibits folic acid synthesis

A

Trimethoprim: given with SMX

49
Q

Bacterium treats

A

MRSA, SE: rash and SJS

50
Q

inhibits nucleic acid synthesis and only treats anaerobes and parasites
REACTION!

A

Metronidazole:
B. fragilis, h. pylori, c. dif
Disulfiram run with alcohol.

51
Q

IV power house antibiotic

inhibit protein syntheses

A

Vancomycin

MRSA, endocarditis, pneumonia,

52
Q

Mus and nicotinic agonist

Local eye use

A

Acetylcholine

can treat myasthenia gravis

53
Q 
Muscarinic antagonist
blocks SLUD (cross BBB)
A

Atropine

SE: blurry vision, dry month, tachy

54
Q

mus agonist

Specific to SM and bladder

A

Behtanechol

Treat urinary retention, ocular diagnosis

55
Q

Muscarnic antagonist inhaled
Tx?
Mucosal accumulation

A

Ipratropium Asthma/COPD

SE: dry mouth

56
Q

Alpha and beta receptors (local alpha)

Tx?

A

Epinephrine

anaphylaxis and cardiac emergency

57
Q

Alpha 1 receptor

nasal decongestant, mydriatic

A

phenylephrine

Rebound

Pharm (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions