Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharm > Pharm 1 Final > Flashcards

Pharm 1 Final Flashcards

1
Q

Malaria and P. falciparum Treatment

A

DOC Chloroquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Amebiasis/ protozoa

A

DOC Metronidazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Helminths

A

DOC Mebendazole: microtubule destruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Ectoparasites, helminths, arthropods

A

Ivermectin

DOC ectoparasites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MOA: inhibits DNA, transcription, and nuclear acid function

A

Cyclophosphamide: ALL, Lymphoma, brest, Ovarian, Lung, Multiple myeloma, sarcasm and CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

MOA: competivitly inhibits dihydrofolate reductase

A

Methotrexate: DMARD, AI dz (immunosuppressant)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

SE: Red urine

A

“Rub” pigment = doxorubicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Broadest anti-neoplastic

A

doxorubicin -> anti-biotic like agent, antracylcine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

neoplastic with cardio toxicity

A

doxorubicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Microtubule inhibitor (neoplasm)

A

pacletaxel –> joint pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q 
estrogen antagonist (selective competitor)-> early breast CA
agonist in uterine tissue
A

Tamoxifen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Breast and ovarian CA treatment

A

Pacletaxel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Inactivates Plasmodium (polymerizes heme)

A

chloroquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

intensifies release of GABA

A

affects SM of worms–> ivermectin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Na/K/Cl in Thick ascending loop of hence

its with low GFR (kid dz)/HTN emergences

A

furcosimide: loop diuretic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Na.cl in Distal tubule

Increases osmolality w/in nephron(water retained

A

hydrochlorothiazide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q 
potassium-sparing
inhibits aldosterone (competitively) in heart, arterial, and kidneys
A

spironolactone: acne tx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Inhibits angiotensin converting enzyme in lungs (less angiotensin II)
Use for DM, HF with diuretic and digitalis

A

ACE: lisinopril

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

CCB (L-type) of Sm, prevents bundle of his, AV node from firing
Tx?

A

Diltiazem (Class IV)

tx HTN, angina, arrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Beta 1 and 2 inhibitor (NO DM or asthma)
tx?
lipid soluble

A

Propranolol (Class II)
tx: HTN, angina,
Phase 4 dipolar)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Blocks beta 1/antagonizes catecholamines

Tx? DM and asthmatics

A

Metoprolol: (Class II)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Rate Control

A

Class II (BB), IV (CCB), V (digoxin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Rhythm Control

A

Class Ia (Na/K open), Ic (Na open) and III (LKr inhibitor)

24
Q

Beta 1 blocker, higher mortality except silent ischemia

Neg chronotropic and inotropic effects

A

Atenolol

tx: angina, HTN

25
alpha 1 blockage activity (blood vessels) tx? Grapefruit juice
Carvedilol (alpha and beta) | tx: MI, HTN, CHF, angina
26
Decreases preload relax SM, vasodilation immediate relief TX?
nitroglycerine (stimulate NO receptors) | DOC angina, HF
27
antioxidant to NO, vasodilator TX? Lupus like syndrome --> ANA+
Hydralazine | Tx: HF (africa americans), angina, anterior dilator
28
Na/K-ATPase inhibitor Slows AV node Cardiac glycoside
Digoxin (Class V) tx: CHF and SVT, arrhythmias slim margin of safety (blood sample
29
IKr channel blocker (phase 3 repolar) Tx? Adverse RXN?
Amiodarone: Class 3 Tx: arrhyythmias (vent supra vent), atach/afib, SE:corneal deposits, thyroid d/o (like T4), photosensitivity, pull. fibrosis.
30
Blocks open Na/K channel (slow phase 0) Tx? SE?
quinidine (Class 1a) Tx: fib, attach, anti-parasite (malaria) SE: TTP, torsades, cinchonism
31
Guanosine analog decrease viral replication via DNA rep. BBB?
Acyclovir: Herpes (HSV, and VZV) Treat: HSV meningitis encephalitis
32
Block P2Y12 of ADP on platelet surface (no GPIIb/IIIa complex)
Clopidogrel: anti-thrombotic platelet lifetime interest with everything
33
HMG-CoA reductase inhibitor First SE? Red yeast, niacin, alcohol, SJW, sweet orange
Atorvastatin: ASCVD, hyperchol (decrease LDL) Muscle soreness Upreg. LDL receptors (liver)
34
Prevents absorption of dietary and biliary cholerstol (enterohepatic circulation and chylomicron assembly
``` Ezetimibe stain intolerance, still upreg, LDL receptors, decrease plasma LDL fecal clearance (80%) ```
35
anti-neoplastic resistant CA
melanoma, brain CA, Renal cell CA
36
MC open-angle glaucoma treatment Prostaglandin analog SE?
latanoprost --> increase aqueous outflow | SE: iris pig., ocular irration
37
Topical MRSA and Impetigo Tx
Mupirocin | inhibits bac protéine synthesis
38
Increases permeability by binding to ergosterol in fungus | Pre-treat?
Amphoterricin B | --> anti-his, anti-paretics, cortico
39
Blocks formation of ergosterol (static) | Tx?
Floconazole (not with warfarin) | Candida of mucous mem.
40
Leukotrine modifier, (LTD4) which inhibits lipogenase
Montelakast | Asthma/COPD
41
Phosphodiesterase inhibitor, relax SM | Limited clinical use
Theophylline | hyperstimulation
42
Bind to bac ribosome irrversibly binds MC used amino glycoside tx?
Gentamicin: bac conjuncivitis, broad spectrum (nephron/ototoxicity)
43
beta lactam and lactase inhibitor | Treats:
Augmentin(amoxicillin clavulinate) Enterococci (b. fragilis), OM, UTI, sinusitis, bronchitis (endocard=IV) most serve AID (c. diff)
44
binds to PBP which inhibits cell wall synthesis
Cephalexin | No enterococcus, pen allergy
45
Macrolide, bind 50s rib subunit | Tx:
Azithromycin | atypical resp. pathogens (legion, chlym, mycoplasma)
46
Binds 30s bac rib, Tx? SE:
Doxy=Resp/sinusitis Tetracycline= MRSA H. Inf, Rickettsiae, atypical rest path. SE: photosens./teeth discoloration
47
Prevents folic acid inhibition
Sulfamethoxazole: given with TMP | Best tx for UTI
48
inhibits folic acid synthesis
Trimethoprim: given with SMX
49
Bacterium treats
MRSA, SE: rash and SJS
50
inhibits nucleic acid synthesis and only treats anaerobes and parasites REACTION!
Metronidazole: B. fragilis, h. pylori, c. dif Disulfiram run with alcohol.
51
IV power house antibiotic | inhibit protein syntheses
Vancomycin | MRSA, endocarditis, pneumonia,
52
Mus and nicotinic agonist | Local eye use
Acetylcholine | can treat myasthenia gravis
53
``` Muscarinic antagonist blocks SLUD (cross BBB) ```
Atropine | SE: blurry vision, dry month, tachy
54
mus agonist | Specific to SM and bladder
Behtanechol | Treat urinary retention, ocular diagnosis
55
Muscarnic antagonist inhaled Tx? Mucosal accumulation
Ipratropium Asthma/COPD SE: dry mouth
56
Alpha and beta receptors (local alpha) | Tx?
Epinephrine | anaphylaxis and cardiac emergency
57
Alpha 1 receptor | nasal decongestant, mydriatic
phenylephrine | Rebound

Pharm (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions