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Pharmacology > Pharm 1 (autonomics, hematologics, antineoplastics) > Flashcards

Pharm 1 (autonomics, hematologics, antineoplastics) Flashcards

1
Q

Ephedrine

A

Indirect sympathomimetic - indirect general agonist, releases stored catecholamines

Nasal decongestion, urinary incontinence, hypotension

pseudoephedrine commonly used

*activity reduced by prior tx w/ reserpine/guanethidine

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2
Q

Amphetamine

A

Indirect sympathomimetic - indiret general agonist, reuptake inhibitor, & releases stored catecholamines

Tx - Narcolepsy, obesity, attention deficit disorder

*activity abolishied by prior tx w/ reserpine/guanethidine

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3
Q

Cocaine

A

Indirect symphathomimetic - indirect general agonist & reuptake inhibitor

Causes vasoconstricion & local anesthesia

NEVER give β-blockers if cocaine intoxication is suspected (can lead to unopposed α1 activation & extreme hypertension)

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4
Q

Prazosin
Terazosin
Doxazosin
Tamsulosin

A

α1 selective antagonist (-osin)

Urinary symptoms of BPH, HTN, PTSD (prazosin)

Tamsulosin - solely used for BPH (α1a selective)

AE - 1st dose orthostatic HoTN, dizziness, headache

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5
Q

Yohimbine

A

α2 antagonist - increases central sympathetic activity
= ↑ BP & HR

Tx - male erectile dysfunction, HoTN

AE - anxiety, (excess pressor effect if NET1 is blocked)

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6
Q

Phenoxybenzamine

A

Irreversible nonselective α antagonist (long DoA)
= ↓ BP, ↑ HR (baroreflex +)

Tx - pheochromocytoma (catecholamine releasing tumor in the adrenal gland)

AE - orthostatic HoTN, reflex tachycardia, MI

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7
Q

Phentolamine

A

Reversible nonselective α antagonist

Given to Pt on MAOI who eat tyramine-containing foods

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8
Q

Mirtazapine

A

α2 selective antagonist

Tx - Depression

AE - Sedation, ↑ serum cholesterol & appetite

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9
Q

Labetalol

Carvedilol

A

Nonselective α- & β-antagonists
=↓ BP w/ limited HR ↑ (↓ reflex tach by also blocking α1)

Tx - HTN

(-ilol & -alol instead of -olol of B selective)

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10
Q

Nadolol
Pindolol
Propranolol
Timolol

A

Nonselective β-antagonists (β1=β2)
= ↓ HR, BP & reduce Renin

Tx - HTN, angina pectoris, arrhytmias, migraine, hyperthyroidism

↑ bronchospasm (β2)

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11
Q 
Atenolol
Metoprolol
Esmolol
Beliprolol
Acebutolol
A

Selective β-antagonists (β1>β2)
= ↓HR, BP & reduce renin
safer on asthma

Tx - HTN, angina pectoris, arrhytmias

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12
Q

Pindolol & Acebutolol

A

β-antagonists w/ ISA (intrinsic sympathomimetic activity)
=↓BP, but only modestly ↓ HR
block receptors but elicit a small response

Tx - HTN, arrhytmias, migraine

may avoid worsening of bradycardia

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13
Q

β-blockers

A

-olol (-alol, -ilol)

Tx - angina pectoris (↓HR & contractility = ↓ O2 need)

  • MI (↓ mortality - metoprolol, carvedilol, bisoprolol)
  • SVT (↓ AV conduction, class II - metoprolol esmolol)
  • HTN (↓ CO, ↓ renin (due to blockade of JGA cells)
  • CHF (slows progression of chronic failure)
  • Glaucoma (↓ secretion of aqueous humor - timolol)

AE - impotence, CV (bradycardia, AV block, CHF), dyslipidemia (metoprolol), CNS (seizures, sedation)

may cause exaceration in asthma/COPD (especially nonselective, through blockade of β2)

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14
Q

Phenylephrine

A

Direct sympathomimetics - α1>α2 (=vasoconstriction)
= ↑ BP, ↑ TPR & reflex bradycardia

Tx - HoTN, ocular procedures (mydriatic), decongestant

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15
Q 
Albuterol
Salmeterol
Terbutaline
(Metaproterenol)
(Ritodrine)
A

Direct sympathomimetics - β2>β1 (=bronchorelaxation)

Tx - Acute asthma (albuterol)

 - Long-term asthma/COPD (Salmeterol)
 - Reduce premature uterine contractions (terbutaline)
     - ritodrine designed specifically as uterine relaxant
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16
Q

Isoproterenol

A

Direct sympathomimetic - β1=β2
= ↓ TPR, ↑ HR, ↑ myocardial contractility

Tx - Electrophysiologic evaluation of tachyarrhythmias
can worsen ischemia

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17
Q

Dobutamine

A

Direct Sympathomimetic - β1>β2,
= + inotropic, + chronotropic, (TPR not affected)

Tx - heart failure (inotropic>chronotropic), stress testing

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18
Q

Epinephrine

A

Direct sympathomimetic = β>α
(α effects dominate at high doses)

Tx - Anaphylaxis, open angle glaucoma, asthma, HoTN

CI - PT using nonselective β-blockers (=severe vasoconstriction)

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19
Q

Norepinephrine

A

Direct sympathomimetic = α1>α2>β1
↑ BP, PP, TPR & Coronary flow, ↓ CO & renal perfusion

Tx = HoTN (but ↓ renal perfusion) - dose titration needed

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20
Q

Dopamine

A

Direct sympathomimetic - D1=D2>β>α
(inotropic & chronotropic α effects predominate at high dose)

Unstable bradycardia, heart failure, shock

Hypovolemia should always be corrected before use
Avoid w/ MAOI or tricyclic antidepressants

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21
Q

Fenoldopam

A

Direct agonist - D1 selective

Tx - Hypertensive crisis (renal, mesenteric, peripheral & coronary vasodilation) (= renal blood flow maintained & natriuresis promoted)

AE - HoTN

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22
Q

Clonidine

α-methyldopa

A

Sympatholytics - α2 selective agonist
(↓ BP by ↓ central sympathetic outflow)

Tx - Hypertensive urgency (doesn’t ↓ renal blood flow)

α-methyldopa for HTN in pregnancy (safe in pregnancy but causes DIrect Coombs + hemolytic anemia, SLE-like syndrome)

Clonidine AE - CNS depression bradycardia, HoTN, respiratory depression & small pupil size

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23
Q

Atropine
Homatropine
Tropicamide

A

Muscarinic antagonists

Organ system - eye

Tx - produce mydriasis & cycloplegia

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24
Q

Ipratropium

tiotropium

A

Muscarinic Antagonists

Organ system - respiratory

Tx - COPD, asthma (↓ bronchoconstriction & bronchial secretions)

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25
Q

Atropine

A

Muscarinic antagonist - used to treat bradycardia & for ophthalmic applications

Blocks DUMBBeLSS

Eye - pupil dilation, cycloplegia
airway- ↓ sectretions
Stomach - ↓ acid secretion
Gut - ↓ motility
bladder - ↓ urgency in cystitis

AE - Hot, Dry, Red, Blind, Mad
↑ temp (by ↓ sweating); rapid pulse; dry mouth; dry, flushed skin; cycloplegia; constipation; disorientation

Causes acute angle-closer glaucoma in elderly (due to mydriasis), urinary retention in men w/ prostatic hyperplasia, & hyperthermia in infants

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26
Q

Benztropine

A

Muscarinic antagonist

Organ system - CNS

Tx - Parkinson disease
=re-establishes dopaminergic-cholinergic balance

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27
Q

Scopolamine

A

Muscarinic antagonist

Organ system - CNS

Tx - Motion sickness

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28
Q

Oxybutynin
Darifenacin
Solifenacin

A

muscarinic antagonist

Organ system - Genitourinary

Tx - Reduce urgency in mild cystitis & ↓ bladder spasms

(Other agents - tolterodine, fesoterodine, trospium)

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29
Q

Hexamethonium

Mecamylamine

A

Nicotinic Antagonists

↓ predominant autonomic tone & prevent baroreflex

SANS - arterioles = vasodialtion & HoTN
- Veins = Dilation, ↓ venous return, ↓ CO
- Sweat glands = Anhidrosis
PANS - Heart = tachycardia
- Iris = Mydriasis
- Ciliary muscle = Cycloplegia (loss of accommodation)
- GI = ↓ tone & motility = constipation
- Bladder = urinary retention
- Salivary glands = Xerostomia

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30
Q

Succinylcholine

d-Tubocurarine

A

Nicotinic Antagonists

block Nm channel (neuromuscular blockade)
S-bind & keep channel open=persistent depol & paralysis
T-bind and prevent openeing of channel

Tx of convulsions, & ↓ neuromuscular transmission during anesthesia; used in tracheal intubation to control ventilation

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31
Q

Methacholine

A

Cholinomimetic agent - Direct agonist
= stimulates muscarinic receptors in airway when inhaled

Tx - Challenge test for diagnosis of asthma

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32
Q

Carbachol

A

Cholinomimetic agent - Direct agonist
= “CARBon copy” of AcetylCHOLamine

Tx = Glaucoma, pupillary constriction, & relief of intraocular pressure

High doses may induce cardiac arrest

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33
Q

Bethanechol

A

Cholinomimetic agent - Direct agonist
= activates Bowel & Bladder smooth muscle cells
- resistant to AChE

Tx - Post-op ileus, neurogenic ileas, urinary retention

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34
Q

Muscarine Poisoning

A

Salivation, sweat, tear flow
Abdominal pain, N, D
Blurred vision, dyspnea
severe = cardiac & respiratory failure

Wet

35
Q

Pilocarpine

A

Cholinomimetic agent - Direct acting
= Contacts ciliary muscle of eye (open-angle), & pupillary sphincter (closed-angle)
- Resistant to AChE

Tx - Open & Closed-angle glaucoma
- Potent stimulator of sweat, tears, & saliva
(cry, drool, & sweat on your PILOw)

36
Q

Edrophonium

A

Indirect acting cholinomimetic = anticholinesterase
= ↑ endogenous ACh - Short acting

Dx myasthenia gravis (historical; now dx w/ anti-ACh↑R A

↑ ACh makes better = MG; worse = cholinergic crisis

37
Q

Neostigmine

A

Indirect acting cholinomimetic = anticholinesterase
= ↑ endogenous ACh - intermediate acting
No CNS penetration

Tx - Post-op & neurogenic ileus & urinary retention; myasthenia gravis, reversal of Nm junction blockade (post-op)

38
Q

Pyridostigmine

A

Indirect acting cholinomimetic = anticholinesterase
= ↑ endogenous ACh; ↑ strength - long lasting
Does not penetrate CNS

Tx - Myasthenia gravis (pyRIDostiGMine)

39
Q

Physostigmine

A

Indirect acting cholinomimetic = anticholinesterase
= ↑ endogenous ACh
crosses BBB = enters CNS

Tx - anticholinergic toxicity (phyxes atropine overdose)

40
Q

Donepezil
Rivastigmine
Galantamine
(Tacrine)

A

Indirect acting cholinomimetic = anticholinesterase
= ↑ endogenous ACh
Lipid soluble - CNS entry

Tx - Alzheimer disease

41
Q

Anticholinesterase poisoning

A

often due to organophosphates, like parathion, that irreversibly inhibit AChE

=DUMBBELSS

Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation (of skeletal muscle & cns), Lacrimation, Sweating, Salivation

Antidote = atropine (competitive inhibitor) + pralidoxime (regenerates AChE if given early)

42
Q

Heparin
(Enoxaparin - LMWH)
(Fondaparinux)

A

Indirect Xa inhibitor (cofactor for the activation of antithrombin) = ↓ thrombin & ↓ factor Xa

Tx - Immediate anticoagulation for PE, acute coronary syndrome, MI, DVT
- Used during pregnancy (doesn’t cross placenta)

Monitor w/ PTT
Antidote = protamine sulfate

AE - bleeding, HIT, osteoporosis, drug-drug interactions

43
Q

Argatroban
Bivalirudin
(Lepirudin)

A

Direct thrombin inhibitors (derived of hirudin from leeches)

Tx - anticoagulation in Pt w/ HIT

44
Q

(Dabigatran)

A

Direct thrombin inhibitor - Oral

Tx - stroke prevention in Pt w/ A. Fib
- prevention of DVT & PE

*shown to be as effective as warfarin w/ less bleeding/hemorrhage risk

45
Q

Warfarin

A

Vitamin K antagonist
= inhibits synthesis of II, VII, IX, X & Protein C, S

Tx - Chronic anticoagulation (after STEMI, venous thromboembolism propylaxis, prevention of stroke in A. Fib)
- crosses placent = NOT used in pregnancy

Monitor w/ PT/INR (effects extrinsic pathway)
Antidote = Vitamin K

AE - Bleeding, teratogenic, skin/tissue necrosis, drug-drug interactions

46
Q

Rivaroxaban

Apixaban

A

Direct Factor Xa inhibitors (bind & directly inhibit Xa)

Tx - stroke prophylaxis in Pt w/ A. Fib
- Tx & prophylaxis of DVT & PE (rivaroxaban)

AE - Bleeding (no specific reversal agent)

47
Q

Alteplase (tPA)
Reteplase (rPA)
Tenecteplase (TNK-tPA)

A

Thrombolytics = directly or indirctly aid conversion of plasminogen to plasmin = cleaves thrombin & fibrin clots

= ↑PT, PTT (no change in platelet count)

Tx - Early MI, early ischemic stroke, direct thrombolysis of severe PE

AE - Bleeding
CI - PT w/ active bleeding, Hx of intracranial bleeding, recent surgery, known bleeding diatheses, severe HTN

Antidote = aminocaproic acid (inhibits fibrinolysis)
-FFP or cryo can also be used to correct factor deficiency

48
Q

Aspirin (ASA)

A

Antiplatelet drug = Irreversibly inhibits COX (1&2) enzyme by covalent acetylation -acts until new platelets produced

↑ bleeding time, ↓TXA & prostaglandin (no effect PT/PTT)

Tx - antipyretic, analgesic, anti-inflammatory, antiplatelet (↓ aggregation)

AE - Gastric ulceration, tinnitis (CN VIII)

  • Chronic use = acute renal failure, interstitial nephritis, & upper GI bleeding
  • Reye syndrome in children w/ viral infection

Overdose = respiratory alkalosis then metabolic acidosis

49
Q

Clopidogrel
Prasugrel
Ticlopidine
Ticagrelor

A

Inhibit platelet aggregation by irreversibly blocking ADP receptors. (Inhibit fibrinogen binding by preventing glycoprotein IIb/IIIa from binding to fibrinogen)

Tx - acute coronary syndrome; coronary stenting
- ↓ incidence of recurrence of thrombotic stroke

AE - TTP/HUS may be seen
- Neutropenia (ticlopidine)

50
Q

Dipyridamole

Cilostazol

A

Antiplatelet drug = Phosphodiesterase III inhibitor - ↑ cAMP in platelets = inhibit aggregation; (vasodilators)

Tx - intermittent claudication, coronary vasodilation, prevention of stroke or TIAs (combo w/ aspirin), angina prophylaxis

AE - N, H, facial flushing, HoTN, abdominal pain

51
Q

Abciximab
Eptifibatide
Tirofiban

A

GP IIb/IIIa receptor antagonists = prevent aggregation
Abciximab is made from monoclonal Ab Fab fragments

Tx - Unstable angina, percutaneous transluminal coronary angioplasty (PCI)

AE - Bleeding, Trhombocytopenia

52
Q

(Vorapaxar)

A

PAR (protease activated receptor) antagonist = inhibits effects of thrombin on platelets

Tx - ↓ thrombotic CV events in Pt w/ established PAD or history of MI

AE - intracranial hemorrhage

CI - Pt w/ active bleeding, history of intracranial bleed, or previous TIA/stroke

53
Q

Methotrexate

A

Folic acid analog - inhibits dihydrofolate reductase
= ↓ dTMP = ↓ DNA & protein synthesis

Tx - leukemias, lymphomas, choriocarcinoma, sarcomas
- abortion, ectopic pregnancy, RA, psoriasis, IBD

AE - myelosuppression (reversible w/ leucovorin “rescue”) Macrovesicular fatty change in liver, Mucositis, Teratogenic

54
Q

5-Flourouracil (5-FU)

A

Pyrimidine analog bioactivated to 5F-dUMP, which covalently complexes folic acid = inhibits thymidylate synthase = ↓dTMP = ↓ DNA & protein synthesis

Tx - Colon cancer, pancreatic cancer,
- topical for basal cell carcinoma

AE - Myelosuppression (NOT reversible w/ leucovorin), photosensitivity

Overdose - “rescue” w/ uridine

55
Q

Cytarabine

Fludarabine

A

Pyrimidine analog = inhibition of DNA polymerase

Tx - Leukemias & lymphomas
- ara-C = most important antimetabolite in AML tx

AE - Leukopenia, thrombocytopenia, megaloblastic anemia (CYTarabine causes panCYTopenia)
- high CNS levels = cerevellar syndrome (Dyarthria, nystagmus, ataxia)

56
Q

Azathioprine
6-mercaptopurine (6-MP)
6-thioguanine (6-TG)

A

Purine analog = ↓ de novo purine synthesis; activated by HGPRT

Tx - Leukemia
- Preventing organ rejection, RA, SLE (A), IBD (6s)

AE - Bone marrow suppression, GI & liver
- Azathioprine & 6-MP are metabolized by xanthine oxidase = both ↑ toxicity w/ allopurinol, which inhibits their metabolism

57
Q

Cyclophosphamide

Ifosfamide

A

Nitrogen mustard - covalently cross-link DNA at guanine N-7. Require bioactivation in the liver

Tx - Solid tumors, leukemia, lymphomas & some brain cancers

AE - Myelosuppression, *Hemorrhagic cystitis (partially prevented w/ mesna - binds toxic metabolites)

58
Q

Carmustine
Lomustine
Semustine
Streptozocin

A

Nitrosoureas - Cross-link DNA, cross BBB, require bioactivation

Tx - Brain tumors (including glioblastoma multiforme)
- wafers placed in brain cavity to kill potential microsatellite tumors after surgery

AE - Profound myelosuppression, CNS toxicity (convulsions, dizziness, ataxia)

59
Q

Busulfan

A

Cross-links DNA

Tx - CML
- used to ablate pt’s BM before BM transplant

AE - sever myelosuppression (in almost all cases), pulmonary fibrosis, hyperpigmentation

60
Q

Cisplatin

Carboplatin

A

Platinum compounds = Cross-link DNA

Tx - Testicular, bladder, ovary, & lung carcinomas

AE - Nephrotoxicity, ototoxicity, peripheral neuropathy
- prevent nepthrotoxicity w/ amifostine (free radical scavenger) & chloride diuresis

61
Q

Vinblastine

Vincristine

A

Bind β-tubulin = Inhibit polymerization of microtubules = prevent mitotic spindle formation = cell arrest in metaphase (M-phase) & cell death

Tx - Solid tumors, leukemias, & lymphomas

AE - VC - neurotoxicity (areflexia, peripheral neuritis)
- VB - significant myelosuppression (blasts BM)

62
Q

Paclitaxel
Docetaxel
(other -taxels)

A

Hyperstabilize polymerized microtubules in M phase so that mitotic spindle cannot break down (anaphase can’t occur)

Tx - Ovarian & breast cancers

AE - myelosuppression, alopecia, hypersensitivity

63
Q

Etoposide

Teniposide

A

Inhibits Topoisomerase II = ↑ DNA degredation

Tx - Solid tumors (particularly testicular and small cell lung cancer), leukemias, lymphomas

AE - myelosuppression, GI irritation, alopecia

64
Q

Irinotecan

Topotecan

A

Inhibit topoisomerase I = prevent DNA unwinding & replication (S-phase specific)

Tx - Colon cancer (I),
- Ovarian & small cell lung cancer (T)

AE - Severe myelosuppression, diarrhea

65
Q

Hydroxyurea

A

Inhibits ribonucleotide reductase = ↓ DNA synthesis (S-phase specific)

Tx - melanoma, CML
- sicle cell disease (↑ HbF)

AE - Bone marrow suppression, GI upset

66
Q

Doxorubicin (Adriamycin)
Daunorubicin
Epirubicin

A

Intercalate in DNA = breaks in DNA = ↓ replication
Generate free radicals

Tx - Solid tumors, leukemias, lymphomas

AE - Irreversible dilated cardiomyopathy***, myelosuppression, alopecia, toxic to tissues following extravasation

Dexrazoxane (iron chelator) helps prevent cardiotoxicity

67
Q

Bleomycin

A

Induces free radical formation, which causes breaks in DNA strands (causes cell to arrest in G2 phase)

Tx - testicular cancer, Hodgkin lymphoma

AE - Pulmonary fibrosis (dose-limiting pulmonary toxicity), skin changes, mucositis, limited myelosuppression

68
Q

Dactinomycin (actinomycin D)

A

Intercalates in DNA

Tx - Wilms tumor, Ewing sarcoma, rhabdomyosarcoma
- used for childhood tumors (children ACT out)

AE - myelosuppression

69
Q

Prednisone

Prednisolone

A

May trigger apoptosis - even work on nondividing cells

Tx - CLL, non-Hodgkin lymphoma (in combo)
- immunosuppressants (for autoimmune disease etc.)
Most commonly used glucocorticoids in cancer chemotherapy

AE - Cushing-like symptoms (weight gain, central obesity, muscle breakdown, cataracts, acne, osteoporosis, hypertension, peptic ulcers, hyperglycemia, psychosis)

70
Q

Tamoxifen

Raloxifene

A

SERM - receptor antagonists in breast & agonists in bone. Block the binding of estrogen in ER + cells

Tx - (T) - breast cancer treatment & prevention
- (R) - Prevention of Breast cancer & osteoporosis

AE - hot flashes

  • (T) ↑ risk of endometrial cancer (partial agonist in endometrium)
  • (R) endometrial antagonist = no ↑ risk of cancer
71
Q

Trastuzumab (Herceptin)

A

Monoclonal Ab against HER-2 (tyrosine kinase receptor) = helps kill breast cancer cells that overexpress HER-2 through inhibition of HER2-initiated cell signaling & Ab-dependent cytotoxicity

Tx - HER-2 + breast cancer & gastric cancer

AE - Cardiotoxicity (HEARTceptin)

Tras2zumab (HER-2 inhibitor)

72
Q

Imatinib (Gleevac)

A

Tyrosine kinase inhibitor of bcr-abl (Philadelphia chromosome fusion gene in CML) & c-Kit (common in GI stromal tumors)

Tx - CML, GI stromal tumors

AE - Fluid retention

73
Q

Rituximab

A

Monoclonal Ab against CD20, which is found on most B-cell neoplasms

Tx - Non-Hodgkin lymphoma, RA (w/ MTX), ITP

AE - ↑ risk of progressive multifocal leukoencephalopathy

74
Q

Vemurafenib

A

Small molecule inhibitor of forms of the B-Raf kinase w/ V600E mutation

Tx - metastic melanoma

75
Q

Bevacizumab

A

Monoclonal Ab against VEGF = Inhibits angiogenesis

Tx - Solid tumors (colorectal cancer, renal cell carcinoma)

AE - Hemorrhage & Impaired wound healing

76
Q

(Thalidomide)

A

Inhibit release of VEGF
Inhibit IL-6 & TNF-α expression, release & signaling
Enhances activity of NK & T cells

An important Tx for multiple myeloma

AE - Peripheral sensory neuropathy (10-30%)
- constipation (commonly)

77
Q

(Interleukin-2)

A

↑ killing activity of NK cells & ↑ T-cell proliferation

Tx - metastatic renal cancers & metastatic melenomas

AE - causes intravascular fluid leaks = significant alterations in electrolyte concentrations, cardiac arrhythmias, edema, HoTN, respiratory difficulties, renal failure

78
Q

(Bortezomib)

A

Small molecule inhibitor of proteosome = prevents proteosomal degradation of p53
Inhibition of transcriptional activity of NF-kB (normally ↑ tumor cell survival in hypoxic environments)

Tx - Multiple myeloma (& combo tx in other myelomas)

AE - peripheral neuropathy; thrombocytopenia, neutropenia, fatigue, anemia, vomiting, limb pain, dehydration, nausea

79
Q

(tretinoin)

A

Induces differentiation in APL (acute promyelocytic leukemia)

Tx - APL = high rate of complete remission as single agent (can be combined w/ anthracyclines)

80
Q

(Gemcitabine)

A

Inhibits ribonucleotide reductase = ↓ DNA precursors
Incorporated into DNA = inhibit synthesis & function

Tx - pancreatic, non-small cell lung, ovarian, bladder & other cancers

81
Q

(Mechlorethamine)

A

Nitrogen mustard - alkylating agent

Tx - Hodgkin’s Lymphoma (MOPP = mechlorethamine, vincristine, procarbazine, prednisone)

82
Q

(Anastrazole)

A

Aromatase Inhibitor = cuts off estrogen supply in post-menopausal women

Tx - Estrogen-sensitive breast cancer in post-menopausal women

83
Q

(Flutamide)

Bicalutamide

A

Competitively inhibit testosterone from binding receptor

Tx - prostate cancer

Pharmacology (6 decks)

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