[PHA6113 lab] Activity 6: Shelf-life Determination

Question 1

Study of the rate at which reactions take place

Answer 1

Reaction Kinetics

Question 2

Examples of Reaction Kinetics

Answer 2

Chemical decomposition of a drug, radioactive decay

Question 3

Measures the moles of reactants disappearing or the mole of products appearing per unit time

Answer 3

Rate of Reaction

Question 4

Factors Influencing Rate of Chemical Reaction

Answer 4

Concentration and Temperature

Question 5

The way in which concentration of the reaction influences the rate of chemical reaction

Answer 5

Reaction Order (e.g., zero-order, first-order, second-order, shelf-life, half-life

Question 6

The time when 10% of the drug has been lost (90% remaining)

Answer 6

Shelf-life or t90

Question 7

Formula for Shelf-life or t90

Answer 7

t90 = 0.105/k1

Question 8

The time when 50% of the drug has been lost (50% remaining)

Answer 8

Half-life or t50

Question 9

Formula for Half-life or t1/2

Answer 9

t1/2 = 0.693/k1

Question 10

Minimum energy required for a reaction to take place

Answer 10

Energy of Activation (Ea)

Question 11

Additional energy possessed by reactants above its average energy for a reaction to take place

Answer 11

Energy of Activation

Question 12

T or F: Reaction rate is expected to increase with increased temperature

Answer 12

True

Question 13

T or F: There is only one Ea for every drug

Answer 13

False, Ea is specific to a drug

Question 14

Formula for Preparation of a Standard Curve

Answer 14

C1V1 = C2V2

Question 15

Standard Curve

Answer 15

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Question 16

Formula for Linear Regression

Answer 16

y=bx+a

Question 17

Linear Regression

Answer 17

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