PH3110 - How human biology influences drug handling and action 3 Flashcards
1
Q
Under what conditions does the approach to equilibrium AND loss of drug from tissue take longer?
A
Poor perfusion
Greater partitioning into the tissue
2
Q
Which type of limitation takes longer than perfusion-rate limitation?
A
Permeability-rate limitation
3
Q
What three factors cause the equilibrium unbound concentration in tissue to be different from that in plasma?
A
pH gradient across cell membrane
Active transport
Maintenance of sink conditions in eliminating organ
