Ph3: Endocrinology Flashcards
1
Q
What does DPP4 stand for and what is its role?
A
Dipeptidyl Peptidase 4 is an enzyme that breaks down GLP-1 and GIP.
2
Q
What effect does GLP-1 have on the body?
A
Reduces appetite and gastric emptying.
Increases myocardial contractility.
Inhibits glucagon release. Promotes insulin release.
3
Q
How is GLP-1 released?
A
Released from enterocytes in iluem and colon, 15 minutes after a meal. It is from neural stimulation from a closed enteric loop.
4
Q
What do “gliptins” do?
A
DPP4 Inhibitor that prevents breakdown of GLP-1 and GIP. Allows GLP-1 and GIP to circulate longer.
5
Q
What do “glutides” do?
A
GLP-1 analogues that mimic GLP-1. Have more pronounced effect than endogenous GLP-1
