PGX AND CANCER Flashcards
1
Q
WHAT IS Nudix hydrolase 15 (NUDT15) assosciated with
A
metabolism and inactivation of 6MP and its active metabolites
2
Q
what is low activity of NUDT15 assosciated with
A
associated with severe adverse effects eg severe bone marrow suppression
3
Q
what does DPD do?
A
inactivates 5FU into 5,6-dihydro-fluorouracil and is encoded by the DPYD gene
4
Q
individuals with DPD *2A OR *13 must not what
A
must not be treated with Fluoropyrimidines as there is a high risk of life-threatening or fatal toxicity
5
Q
A
