Peripheral Neuropathy

Question 1

What are the two main categories of peripheral neuropathies.

Answer 1

Sensory neuropathies.

Motor neuropathies.

Question 2

What are the causes of sensory neuropathies. (6)

Answer 2

Diabetes. 
Alcohol. 
Rheumatoid arthritis. 
Drugs. 
Malignancy. 
B12 deficiency. 
Chronic renal failure.

Question 3

What are the causes of motor neuropathies. (4)

Answer 3

Guillian-Barre syndrome.
Lead toxicity.
Porphyria.
Charcot-Marie-Tooth disease.

Question 4

What are the clinical signs and symptoms of sensory peripheral neuropathies.

Answer 4

Usually there is a sensory loss in a stocking distribution.

Question 5

What is the treatment of peripheral neuropathies aimed at.

Answer 5

Aimed at underlying cause.

Question 6

What is Charcot-Marie-Tooth disease.

Answer 6

It is part of a group of hereditary motor and sensory neuropathies.

Question 7

What are hereditary motor and sensory neuropathies. (3)

Answer 7

There are several types.
They are classified according to the genetic mutation.
They involve neuronal degeneration, caused by the mutations to the genes coding the proteins involved in the structure of function of nerve axons or myelin sheaths.

Question 8

What inheritance is involved in the hereditary motor and sensory neuropathies. (2)

Answer 8

Mostly autosomal dominant.

There are X linked varieties.

Question 9

What is the life expectancy for patients with hereditary motor and sensory neuropathies.

Answer 9

Normal life expectancy.