Peripheral Blood and Hematopoiesis HISTOLOGY

Question 1

Name the 2 type of leukocytes

Answer 1

Granular

Agranular

Question 2

Which cells are granular?

Answer 2

neutrophils, eosinophils, basophils

Question 3

Which cells are agranular?

Answer 3

lymphocytes and monocytes

Question 4

What does plasma contain?

Answer 4

anti-coagulants
plasma(fluid)
buffy white coat
RBC/hematocrit

Question 5

What does Serum contain?

Answer 5

fibrin clot w/ trapped RBC and WBC
Serum or remaining liquid portions
no anti-coagulants

Question 6

What are the lineage for blood cells

Answer 6

myeloid and lymphoid lineages

Question 7

Why do RBC able to go through small capillaries?

Answer 7

It has a flexible membrane.

Question 8

Where is eliptocytosis or sphereocytosis

Answer 8

defect of the cytoskeleton of RBC

leads to anemia, jaundice, and splenomegaly

Question 9

What is the major protein in the RBC cytoskeleton

Answer 9

spectrin

Question 10

granular cells are from what lineages?

Answer 10

myeloid lineage

eosinophils, basophils, neutrophils

Question 11

agranular cells are from what lineage

Answer 11

both:
monocytes are from myeloid lineage
lymphocytes are from lymphoid lineages

Question 12

B lymphocytes can differentiate into what cells?

Answer 12

Plasma cells

Question 13

neutrophils characteristics (4?)

Answer 13

granules
3-5 lobed nucleus
life span is a few hours to a few days in connective tissue
phagocytic in early immune response

Question 14

eosinophils characteristics (4)

Answer 14

granules
bilobed nucleus
life span a few hours up to several days in connective tissues
phagocytic

Question 15

basophils characteristics (4)

Answer 15

granules
bilobed nucleus
blue stained
mediates allergic reactions

Question 16

lymphocytes characteristics

Answer 16

agranular
small round (very circular) cells and thins rim of pale cytoplasm
T cells and B cells
Life span is few days to few years (memory cells)

Question 17

Distinguish T cells and B cells

Answer 17

T cells is cell mediated immunity
B cells are humoral immunity and differentiated into plasma cells
Cant distinguish on a slide

Question 18

monocytes

Answer 18

agranular
kidney shaped or oval nucleus
precursors of macrophages and osteoclasts

Question 19

platelets

Answer 19

cytoplasmic fragments of megakaryocytic

participate in blood clotting

Question 20

Relationship b/w differentiation and size

Answer 20

Larger the cell the less differentiated it is

Smaller the cell the more differentiated it is

Question 21

What is significant of the normoblast phase in erythropoiesis?

Answer 21

nucleus extrudes

normoblasts can no longer divide b/c of that!

Question 22

What are the early stages of monocytes?

Answer 22

monoblast and promonocyte

Question 23

Monocytes can differentiate into…

Answer 23

macrophages

Question 24

What comes from the myeloid lineage?

Answer 24

GEMM
Granulocytes, Erythrocytes, Monocytes,
Megakaryocytic

Question 25

Megakaryocytes

Answer 25

derived from megakaryoblasts
large cell w/ single nucleus
nuclear division w/o cytoplasmic division gives rise to megakaryocytic
platelets bud off the cytoplasm of megakaryocytic
polyploid nucleus