Peripheral Blood and Hematopoiesis HISTOLOGY Flashcards
Name the 2 type of leukocytes
Granular
Agranular
Which cells are granular?
neutrophils, eosinophils, basophils
Which cells are agranular?
lymphocytes and monocytes
What does plasma contain?
anti-coagulants
plasma(fluid)
buffy white coat
RBC/hematocrit
What does Serum contain?
fibrin clot w/ trapped RBC and WBC
Serum or remaining liquid portions
no anti-coagulants
What are the lineage for blood cells
myeloid and lymphoid lineages
Why do RBC able to go through small capillaries?
It has a flexible membrane.
Where is eliptocytosis or sphereocytosis
defect of the cytoskeleton of RBC
leads to anemia, jaundice, and splenomegaly
What is the major protein in the RBC cytoskeleton
spectrin
granular cells are from what lineages?
myeloid lineage
eosinophils, basophils, neutrophils
agranular cells are from what lineage
both:
monocytes are from myeloid lineage
lymphocytes are from lymphoid lineages
B lymphocytes can differentiate into what cells?
Plasma cells
neutrophils characteristics (4?)
granules
3-5 lobed nucleus
life span is a few hours to a few days in connective tissue
phagocytic in early immune response
eosinophils characteristics (4)
granules
bilobed nucleus
life span a few hours up to several days in connective tissues
phagocytic
basophils characteristics (4)
granules
bilobed nucleus
blue stained
mediates allergic reactions
lymphocytes characteristics
agranular
small round (very circular) cells and thins rim of pale cytoplasm
T cells and B cells
Life span is few days to few years (memory cells)
Distinguish T cells and B cells
T cells is cell mediated immunity
B cells are humoral immunity and differentiated into plasma cells
Cant distinguish on a slide
monocytes
agranular
kidney shaped or oval nucleus
precursors of macrophages and osteoclasts
platelets
cytoplasmic fragments of megakaryocytic
participate in blood clotting
Relationship b/w differentiation and size
Larger the cell the less differentiated it is
Smaller the cell the more differentiated it is
What is significant of the normoblast phase in erythropoiesis?
nucleus extrudes
normoblasts can no longer divide b/c of that!
What are the early stages of monocytes?
monoblast and promonocyte
Monocytes can differentiate into…
macrophages
What comes from the myeloid lineage?
GEMM
Granulocytes, Erythrocytes, Monocytes,
Megakaryocytic
