Peripheral Arterial Disease Flashcards

1
Q

ESSENCE

A

Refers to narrowing of arteries supplying limbs and periphery

Usually refers to lower limbs, resulting in symptoms of claudication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CLINICAL FEATURES

How does peripheral arterial disease present

A

With intermittent claudication - crampy pain that predictably occurs after walking certain distance, then disapears with rest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

CLINICAL FEATURES

Most common muscles affected

A

Calf muscle, but also affacts thighs and buttocks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CLINICAL FEATURES

Features of critical limb ischaemia

A
  • Remember the 6Ps
    • Pain - burning which is worse at night when leg is raised
    • Pallor
    • Pulselessness
    • Paralysis
    • Paraesthesia
    • Perishing cold
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is Leriche syndrome

A

Occurs with occlusion in distal aorta or proximal common iliac artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Classic triad of Leriche syndrome

A
  • Thigh/buttock claudication
  • Absent femoral pulses
  • Male impotence
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

CLINICAL FEATURES

Signs

A
  • Risk factors
    • Tar staining of fingers
    • Xanthomata
  • Signs of CVD
    • Missing limbs or digits after amputations
    • Midline sternotomy scar from CABG
    • Scar on inner calf from CABG
    • Focal weakness from previous stroke
  • Weak peripheral pulses
  • Inspection
    • Skin pallor
    • Cyanosis
    • Dependent rubor
    • Muscle wasting
    • Hair loss
    • Ulcers
    • Poor wound healing
    • Gangrene
  • Examination
    • Reduced skin temperature
    • Reduced sensation
    • Prolonged capillary refill time
    • Changes during Bueger’s test
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CLINICAL FEATURES

Signs of arterial disease on inspection

A
  • Skin pallor
  • Cyanosis
  • Dependent rubor (a deep red colour when the limb is lower than the rest of the body)
  • Muscle wasting
  • Hair loss
  • Ulcers
  • Poor wound healing
  • Gangrene (breakdown of skin and a dark red/black change in colouration)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CLINICAL FEATURES

Signs of arterial disease on examination

A
  • Reduced skin temperature
  • Reduce sensation
  • Prolonged capillary refill time (more than 2 seconds)
  • Changes during Buerger’s test
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What test is used to assess for peripheral arterial disease in the leg

A

Buerger’s test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Describe Buerger’s test

A
  • 2 parts
  • First part
    • Patient supine, lift legs to angle of 45 degrees at hip, hold them for 1-2 minutes looking for pallor
      • Pallor indicates arterial supply not adequate to overcome gravity
    • Buergers angle refers to angle at which leg is pale due to inadequate blood supply
  • Second part
    • Sitting patient up with legs hanging over bed, blood flows into leg assisted by gravity
    • In healthy patient legs normal pink, in disease they go blue initially and then dark red (rubor)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

INVESTIGATIONS

First choice

A
  • Ankle-brachial pressure index (ABPI)
  • Duplex US
  • Angiography (CT or MRI) with contrast
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is ABPI

A

Ratio of systolic BP in the ankle (around lower calf) compared to systolic BP in arm, taken using Doppler probe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ABPI results

A
  • Normal
    • 0.9-1.3
  • Mild
    • 0.6-0.9
  • Moderate to severe
    • 0.3-0.6
  • Severe to critical ischaemia
    • <0.3
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What can ABPI > 1.3 indicate

A

Calcification of arteries, more common in diabetic patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

MANAGEMENT

General principles for intermittent claudication

A
  • Lifestyle changes
  • Exercise training
  • Medical treatments
  • Surgical options
17
Q

MANAGEMENT

Lifestyle changes

A
  • Stop smoking
  • Exercise
  • Optimise medical treatment of co-morbidities such as hypertension or diabetes
18
Q

MANAGEMENT

Medical treatments for intermittent claudication

A
  • Atovastatin 80mg
  • Clopidogrel 75mg (aspirin if unsuitable)
  • Naftidrofuryl oxalate
19
Q

MANAGEMENT

Surgical options for intermittent claudication

A
  • Endovascular angioplasty and stenting
  • Endarectomy (cutting vessel open and removing plaque)
  • Bypass surgery (graft to bypass blockage)
20
Q

MANAGEMENT

Principles for critical limb ischaemia

A
  • Urgent referal to vascular team
  • Analgesia for pain
  • Urgent revascularisation
    • Endovascular angioplasty and stenting
    • Endarectomy
    • Bypass surgery
    • Amputation (if not possible to restore blood supply)
21
Q

MANAGEMENT

Principles for acute limb ischaemia

A
  • Urgent referal to on-call vascular team
  • Options
    • Endovascular thrombolysis (catheter through arterial system to apply thrombolysis directly to clot)
    • Endovascular thrombectomy (catherter through arterial system and remove thrombus by aspiration)
    • Surgical thrombectomy (cutting open vessel and removing thrombus)
    • Endarectomy
    • Bypass surgery
    • Amputation