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AU2017 Perio Final exam > Periodontitis and the risk for systemic disease part 1&2 > Flashcards

Periodontitis and the risk for systemic disease part 1&2 Flashcards

1
Q

acute phase reaction cascade

A

triggering factors–> local reaction–>mediators –> secondary systemic reaction

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2
Q

what could be triggering factors of the acute phase reaction cascade

A 
infection
necrosis
surgery
neoplasia
radiation
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3
Q

cells of local reaction

A

macrophages

fibroblasts

endothelial and other cells

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4
Q

mediators that are produces by local reactors

A

TNF-alpha
IL-1
IL-6
IFN-y

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5
Q

secondary systemic rxn effects

A

fever and leukocytosis

complement activation

serum glucocorticoids increased

altered synthesis of acute phase proteins

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6
Q

important acute phase proteins

A

complement: opsonization, lysis, chemotaxis

protease inhibitors (a2-macroglobulin)

C-reactive protein (CRP): opsonization

Fibrinogen: coag factor

Plasminogen: degrades clots

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7
Q

what defines a risk factor?

A

consistency of assoc.

strength of assoc.

correct time seq.

specificity

degree of exposure

biological pausability

support from experimental evidence

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8
Q

2 systemic diseases that have the strongest association with periodontitis

A

athersclerotic vascular disease

adverse pregnancy outcomes

diabetic complications

respiratory infections

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9
Q

both AVD and periodontitis share several factors, for example patients with these diseases all tend to…

A

be older

male

lower SES

smokers

HTN

under psych. stress

diabetic

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10
Q

what are the 4 major confounding factors in studies of association of periodontitis with AVD?

A

smoking
age
diabetes
education/SES

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11
Q

S. sanguis and P. gingivalis can induce …. events. This action is mediated by collagen-like platelet aggregation associated proteins made by bacteria

A

thrombo-embolic

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12
Q

AVD and Perio:

DNA from periodontal pathogens was found in …. in a study

A

atheromas

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13
Q

macrophages incubated with in vitro P. gingivalis and LDL take up bacteria and transform into … cells similar to those observed in the vessel intima during formaion of atherosclerotic lesions

A

foam

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14
Q

A.a. LPS enhances foam cell formation by macrophages incubated in vitro with …

A

LDL

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15
Q

Gingipains from P. gingivalis up-regulate expression of ….. and down regulate …. in human aortic smooth muscle cells. this change in gene expression increases migration of smooth muscle cells and promotes atherosclerosis

A

angiopoetin 2

antiopoetin 1

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16
Q

studies show that CRP and fibrinogen are … in periodontally diseases subjects

A

elevated

17
Q

periodontal patients treat with SRP did show a reduction in …. but other studies have shown this is not consistent. There also may be a trend toward treatment-induced suppression but the effects are not consistent or sustainable

A

CRP

18
Q

a recent study suggested that treatment of mild-mod periodontitis in other wise healthy patients may result in a significant decrease in carotid artery….

A

intimal-medial thickness

19
Q

the consistency of study finding suggest the observed assoc. between periodontitis and AVD is not a ….

A

false finding

20
Q

the strength of reported associations btn periodontitis and AVD is …

A

modest

21
Q

does periodontitis fully meet the criterion of specificity?

A

no

22
Q

T/F P. gingivalis can induce platelet aggregation

A

true

23
Q

is there enough support to show a causal relationship of periodontitis and AVD

A

no

24
Q

is there anough evidence to show that perio therapy will prevent AVD

A

no

25
Q

inflamed periodontal tissues produce significant quantities of inflammatory mediators including…

A

IL-1b
IL-6
TNF-a
PGE2

26
Q

inflammatory mediators from periodontal tissues can cause placental tissues to release… causing myometrial contraction which contributes to LBW and preterm labor

A

PGE2

27
Q

inflammatory mediators from periodontal tissues can cause increased …. which can cause weakening of the placental membrane leading to preterm labor

A

MMPs

AU2017 Perio Final exam (10 decks)

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