periodontitis Flashcards
What are the influences of the oral microflora
Host factor
- Systemic disease, antibiotic use and oral hygiene methods
Diet
-Chemical composition, physical consistency and frequency of intake
Saliva
-Flow rate, pH balance and antimicrobial factors
Gingival crevicular fluid
- Antimicrobial components and humoral immunity
Microbial interactions
Gaseous environment
PD Classification
Gingivitis
Periodontitis
Nectrotising periodontal disease
Peri-implantitis
What are the development phases
Naked surface
Conditioning film
linking film
coaggregaion, reconditioning film
Accumulation, shedding
What type of bacteria causes the destructive processes
Gram negative Anaerobic
What are the important microorganisms in health
Oral streptococci, Actinomyces, Veillonella, Haemophilus, Neisseri, Fusobacterium
What are the important microorganisms in gingivitis
Actinomyces, Prevotella intermedia, Bacteroides, Fusobacterium nucleatum
They are anaerobic
What are the organisms important in periodontitis
Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia
What model is important related to periodontist and the organisms involved
Socransky’s model
What is Porphyromonas gingivalis
A keystone oral pathogen that is gram negative strict anaerobe
increased numbers in PD
suppressed or undetectable in successfully treated lesions
Increased serum of gingival creviclar fluid in PD
What are the virulence factors of Porphyromonas gingivalis
Fimbriae which helps it attach
has a cocktail of degradative enzymes
-collagenase
-fibrinolysin
-phospholipase A
-phosophatases
Endotoxin (LPS)
Capsular polysaccharide & outer membrane vesicles
Tissue toxic metabolic by-products
-hydrogen sulfide
-ammonia
-fatty acids
What are the virulence factors
Host cell tissue adherence and invasion
-Fimbriae
Elaboration of proteases – ‘cocktail of degradative enzymes’
-collagenase
-fibrinolysin
-phospholipase A
-phosophatases
Endotoxin (LPS)
Capsular polysaccharide & outer membrane vesicles
Tissue toxic metabolic by-products
-hydrogen sulfide
-ammonia
-fatty acids
How do microorganisms adhere
Fimbrillar adhesins:
Help invade membrane vesicle of host cells by binding to cellular integrins
Long fimbriae (FimA)
-Long and peritrichous
-Initial attachment and biofilm organization
Short fimbriae (Mfa1)
-Cell to cell autoaggregation
-Microcolony formation
