Periodontal Q&A Flashcards

1
Q

Q: What is attached gingiva ?
Q1: ____ to ____. There’s fiber attaching this that’s why it’s called “attached gingiva”

Q: What is keratinized attached gingiva ?
Q2: No keratinized tissue below ____ junction.

Is all the attached gingiva keratinized? No the ____ epithelium is NOT keratinized. It is pocket epithelium.
• If you call it pocket = ____
• Sucular epithelium = health gingiva

Q: What is alveolar mucosa ?

A

free gingival margin
muco-gingival junction
muco-gingival
periodontitis

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2
Q
What are four layers of the oral epithelium?
 Q: What is dental gingival UNIT?
Stratum \_\_\_\_ 
Stratum \_\_\_\_ 
Stratum \_\_\_\_ 
Stratum \_\_\_\_

What is the difference between junctional epithelium & non-junctional epithelium?
• Biological width = ____
◦ Only 2.04 mm
Gingival unit = ____ width

A
basal
spinosum
granulosum
corneum
epithelial attachment
biologic
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3
Q

Q: What is clinical attachment loss?

If the marginal gingiva is below the cementoenamel junction (CEJ):
CAL =____

If the marginal gingiva is above the CEJ:
CAL = ____

Gingivitis is now considered kinda healthy because it is impossible to find someone without gingivitis. Most of the time CEJ is detectable, maybe it is not visible but you can use the perio probe to detect the CEJ. Sometimes you can’t because the CEJ is invading the bone level (?).

Why do we use CEJ as the landmark? The CEJ is the only landmark that will remain the same in the presence of ____ & can be used to accurately understand the progression of the disease.

A

pocket depth + [CEJ to marginal gingiva]

[marginal gingiva to CEJ] - [maginal gingiva to bottom of pocket]

inflammation

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4
Q

Q: What is the composition of the connective tissue?
Connective tissue is fibrous, consisting of mostly ____, ground substances, and mucopolysaccharides. It also contains ____, blood vessels, lymphatics, and nerves.

BOARD Q: CT is composed of type I collagen.

A

type I collagen

white blood cells

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5
Q

Q: What are five types of gingival fibers ?

Dentogingival group:
• Fibers extending ____ toward the gingival crest
• Fibers extending ____ to the facial gingival surface
• Fibers extending ____ beyond the alveolar crest height and then apically along the alveolar
bone cortex

Alveologingival group:
Fibers in this group run ____ into the lamina propria from the periosteum at the alveolar crest.

Dentoperiosteal fibers:
These fibers insert into the ____ of the alveolar crest and fan out to the adjacent cementum.

Circular group:
These are the only fibers that are confined to the ____ and do not attach to the ____.

Transseptal group:
These fibers bridge the ____ tissue between adjacent teeth and insert into the cementum.”

Circular group is the ONLY group that does not attach to the teeth.

A

coronally
laterally
horizontally

coronally
periosteum
gingiva
teeth
interproximal
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6
Q
Q: What are the functions of PDL?
• Protect \_\_\_\_ and nerves 
• \_\_\_\_ occlusal forces
• Attach the tooth to \_\_\_\_
• Perform formative and \_\_\_\_ functions
• \_\_\_\_ and Sensory

Q: What is ankylosis?
Ankylosis is the fusion of the ____ and alveolar bone with obliteration of the ____. It develops after chronic periapical ____, tooth re- implantation, and ____ trauma.

Among these fibers, which occupies the most space? ____ because it takes on the most forces.

Reads bullets. One important function of the PDL is the protection from occlusial forces. When you chew - there is not just forces up & down - the tooth distributes the force side to side & in all different directions - the PDL protects from this.

• Implants do not have ____ - there is no sensation. The forces might be too much & you won’t feel it (bc no PDL) & the implant will break.

Anklylosis is kinda a bad thing for the tooth but for implants it’s ____ since there is no PDL.

A
vessels
transmit
bone
remodeling
nutritive

cementum
PDL
inflammation
occlusal

oblique
PDL
necessary

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7
Q

Q: What are acelluar and cellular cementum?
(A) Acellular cementum is located on the ____ at the CEJ. It does not contain ____ and forms slowly.
(B) Cellular cementum is located at the ____ of the root. It is more irregular and forms ____. With age, there is an ____ in width of the cellular cementum.

Inorganic component: 45-50 %
Bone: 65%
Enamel: 97 %
Dentin: 70%

BOARD Q: Which forms first? ____.

BOARDS Q: Gets thicker as you age? ____.
• More potential to heal
• Thicker and thicker as you age

____ is the hardest part of your body because the % inorganic component.

A
enamel
cementocytes
apical third
rapidly
increase

acellular cementum
cellular cementum

enamel

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8
Q

Q: What are acelluar and cellular cementum?
• ____% of the cementum and enamel overlap.
• ____% of the cementum and enamel form a butt joint.
• ____% of the cementum and enamel are separated by a gap.

A

60
30
10

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9
Q

Q: Discuss 4 different types of collagen :
• ____: Skin, tendon, vascular ligature, organs, bone (main component of the organic part of bone)
• ____: Cartilage (main component of cartilage)
• ____: Comprised of reticular fibers, commonly found alongside type I collagen, found in smooth muscle
• ____: Forms basis of cell basement membrane

A

type I
type II
type III
type IV

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10
Q

Glickman classification of furcation involvement (1953)
• Grade I: Pocket formation into the furcation, but intact ____ bone
• Grade II: Loss of ____ bone and pocket formation but not extending through to the ____ side
• Grade III: ____ lesion
• Grade IV: Through-and-through lesion with gingival recession, leading to a clearly ____ furcation area

A
interradicular
interradicular
opposite
through-and-through
visible
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11
Q

Q: What’s the difference of Periodontitis and Gingivitis?

Clinical attachment loss?
-\_\_\_\_
Periodontal pocket > 3 mm? 
-\_\_\_\_
Gingival recession? 
-\_\_\_\_
Bleeding on probing?
-\_\_\_\_

Before 2017: Clinical attachment loss is the ONLY differentiating factor.

After 2017: these are all used to describe periodontitis (??)
• You can use bleeding on ____ to detect inflammation - you can but it is not a sensitive test because other things can cause inflammation, such as trauma. Probing can cause trauma, depending on the skill/ force of the clinician + the design (diameter) of the probe. Probing is considered a dull instrument - because it wouldn’t injure the back of your hand. However, when you walk your probe it can easily cut through the CT tissue, causing bleeding because the junctional epithelium is not healthy & this is why the patient complains of discomfort.

A
yes
no
no
no
probing
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12
Q

Q: What’s the pathogenesis of Periodontitis?

These are all factors that can cause periodontitis.
• NOW we believe that the host ____ response has the biggest role in causing
periodontitis.
• In the past, antibiotics were used much more to treat periodontitis because the microbial role was thought to be the main cause - however, periodontitis still exists so clearly it’s not mainly the ____.

A

immune-inflammatory

microbes

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13
Q

Two types of immune responses

  • Innate Responds (Non-Specific Responds)
  • ____ Responds
  • Created ____ for specific responds happened
  • Not ____

BOARD Q: Difference between innate & delayed response.
Innate = moat around the castle but when you have an intruder, they cannot get in - but some pathogens can bypass the innate response …. So the adaptive immune system comes into play after some time.

A

rapid
time
selective

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14
Q

Two types of immune responses

  • AdaptiveResponds (Specific Responds)
  • ____ responds
  • High ____
  • ____ Mediated
A

slow
selective
antibody

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15
Q

____ are FIRST in an adaptive response.

Part 2 NBDE questions:
Important in:
Parasitic infection & allergic response = ____
Viral infection = ____
Are monocytes & macrophages the same thing? No. Monocyte = ____ cell
Macrophage is ____

A
neutrophils
eosinophil
lymphocyte
precursor
differentiated
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16
Q

Q: PMN are the predominant immune cells in which stage of gingivitis?

Neutrophils are FIRST in an ____ response.
Then the rest come depending on the type of infection -> reads the picture.

A

adaptive

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17
Q
Q: Select from the following cell type that are part of the innate immune responds
 • T cell ?
• B cell ?
• \_\_\_\_ ?
• \_\_\_\_ ?
• \_\_\_\_ Cell ?
• Lymphocyte 

Dendritic cell should be categorized in the innate response but they ARE involved in the ____ response.

A

neutrophil
monocyte
mast
adaptive

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18
Q

(MOST) ____ > ____ > ____ > ____ > ____

A
neutrophil
lymphocyte
monocyte
eosinophil
basophil
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19
Q
Q: Which of the following are cells of the innate immune system? a. Neutrophils and monocytes/macrophages
b. T cells and B cells
c. Mast cells and dendritic cells
• a and b 
• a and c 
• b and d 
• b and c
Q: Which of the following are antigen-presenting cells?
• Neutrophils
• T-lymphocytes 
• Macrophages 
• Plasma cells
A

1) a and c

2) macrophages

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20
Q

Modified Gingival Index
0: Absence of ____
1: ____ inflammation, slight color change, and slight edema but not ____ the entire marginal or papillary unit and no bleeding
on probing
2: ____ inflammation, slight color change, and slight edema ____ the entire marginal or papillary unit and no bleeding on probing
3: ____ inflammation, redness, edema, glazing, bleeding on probing, and hypertrophy of the entire marginal unit
4: ____ inflammation

A
inflammation
mild
involving
mild
involving
moderate
severe
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21
Q

Periodontal Disease Index
• G0: ____ of disease
• G1: Mild to moderate inflammation not ____ around the tooth
• G2: Mild to moderate inflammation ____ around the tooth
• G3: ____ gingivitis and redness

A

absence
extending
extending
severe

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22
Q

Plaque Index
• 0: No ____
• 1: ____ of plaque
• 2: ____ accumulation of plaque within the gingival pocket or on the tooth and gingival margin that can be seen with the naked
• 3: ____ of plaque within the gingival pocket or on the tooth and gingival margin.

A

plaque
film
moderate
abundance

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23
Q

Q: What percentage of the population has aggressive, chronic, and severe periodontitis?

• Localized aggressive periodontitis: ____% (greater prevalence in blacks many studies have proposed that there may be a defect in neutrophil function)

• Generalized aggressive periodontitis: ____%
The 2009 and 2010 National Health and Nutrition Examination Survey found the following data on the prevalence of periodontitis among adults in the United States:

  • 47.2% have periodontitis
  • 8.7% have ____ periodontitis
  • 30% have ____ periodontitis
  • 8.5% have ____ periodontitis”

Which race is most likely to have aggressive periodontitis? ____&raquo_space; Hispanics > Asians > Caucasian
• ____/____ pattern because these are the first teeth erupting in your mouth so they are most impacted by periodontitis.

A

0.53
0.13
mild
moderate
severe

african americans
molar
incisal

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24
Q

Q: Is there anything between periodontist and preterm birth ?

This is an exercise just believe me: the people who like to eat ice cream are more likely to die from drowning.
If you take this funny statement to be true - why could it be true? Confounding factors. You usually eat ice cream in the summer, you also swim in the summer.

Very strong associations = ____ & diabetes

Risk factors = ____ & socioeconomic factors
• very strong association but not causation

THERE ARE studies that show a correlation between pre-term baby and periodontitis but this is very debated - it’s probably somewhat a risk factor but not huge.

A

smoking

age

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25
Q

MASKED INFLAMMATION: Smokers have LESS ____ on probing but the disease is MORE ____.

A

bleeding

severe

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26
Q

Effect of Smoking on etiology and Pathogenesis of Periodontal Disease

Microbiology
Increased ____ pathogens

Immune inflammatory responds
• Altered neutrophil ____, phagocytosis, and oxidative burst
• Increased ____
• Increased the ____

Physiology
• Decreased ____
• Decreased ____

A
periodontal
chemotaxis
collagenases
PGE2
blood vessel
GCF
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27
Q

Q: Which bacteria are associated with refractory periodontal disease? HIV/AIDS?

Refractory periodontitis
____
____
____

HIV/AIDS
____
____

Necrotizing periodontal diseaes
____
____

A

t. forsynthia
p intermedia
p gingivalis

AA
p gingivalis

spirochetes
(t denticola & p intermedia)

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28
Q

Q: Neutrophil Abnormalities and Periodontits

  • ____ syndrome
  • ____ syndrome
A

papillon lefevere

chediak-higashi

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29
Q
Systems and Conditions Possibly Influenced by Periodontal Condition
• \_\_\_\_ 
• Endocrine
• \_\_\_\_
• Respiratory
A

cardiovascular

reproductive

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30
Q

Q: Which medication can cause gingival hyperplasia?

____
-____

____
-____

____
-____

A

anticonvulsants
dilantin (phenytoin)

calcium channel blockers
nifedipine

immunosuppressants
cyclosporine

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31
Q
Patient is a:
• Smoker!
• Hypertension
• Arthritis - inflammatory disease that relates to your immune system
• Diabetes - relates to inflammation

If a patient comes to you sweating & hungry … be careful! What if she’s diabetic & took her medication but DID NOT eat? She’ll ____ on the floor!

A

faint

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32
Q

Pathogenesis of Periodontitis

  • ____ smoking
  • Smokeless tobacco
  • ____
  • Diabetes
  • ____ changes
  • Down Syndrome
  • ____
  • Nutrition
  • Heavy ____
  • Medication

Reads the environmental & acquired risk factors that DO HAVE A CONTRIBUTION in the change of the immune response.

A
cigarette
radiation
hormone
stress
metals
33
Q

Erosion: can be ____
- usually lingual palate because of acid reflux and soda

Abrasion: ____

Attrition: ____

Abfraction: from normal ____ surfaces (inside the tooth) that causes destruction

When I see this clinical presentation - you cannot make a diagnosis you have to figure it out from ____.

A
chemical
brushing
bruxism
occlusion
patient history
34
Q

Facial & Lingual Probing

  • parallel to ____ axis
  • walking the ____
A

vertical

probe

35
Q

Interproximal probing

✓ To detect ____ point of interdental crater
✓ Probe should be placed ____

A

deepest

obliquely

36
Q

Q: Gingivitis is most often caused by:

a. Hormonal imbalance
b. Inadequate oral hygiene
c. Occlusal trauma
d. Vitamin deficiency
e. Aging

A

B

37
Q

Etiology of gingivitis

  • ____
  • host ____

11% of patients do not have good oral hygiene control but they do not proceed to periodontitis - this is from the Sri Lankan worker study
- Proof that there IS a ____ component

Norwegian study
• Most people have ____ periodontitis
• Only 10% had severe
• & the rest had mild

The difference in these studies is that in Sri Lanka they had no concept of ____ whereas in Norwegian study they did (so Sri Lankan was based on people who straight up didn’t know how to brush)

A
plaque
response
genetic
moderate
oral hygiene
38
Q

Most important pathogens to remember: ____, PG, ____, TD, ____

BOARD QUESTION - which bacteria is most related to…
• Pyogenic granuloma? ____
• Localized aggressive periodontitis? ____
• Generalized periodontitis? ____

A

AA
PI
TF

PI
AA
PG

39
Q

Criteria for Defining Pathogenic Microorganisms
• Koch’s postulates (1882)
- A bacteria should be able to be ____ from diseased tissues
- ____ cultures of that bacteria can be obtained
- Bacteria inoculated in experimental animals should cause the ____
- The bacteria should then be ____ in the diseased tissues of the animal

A

isolated
pure
disease
isolated

40
Q

Microbiologic Etiologic Factors

  • Health- and disease-associated bacteria reside in loosely or tightly structured tooth-associated biofilm
  • Health-related bacteria
  • Predominantly gram-____ ____
  • Aerobic or facultative anaerobic species
  • ____
  • ____, purple complex (Socranky 1998)

• Disease-related bacteria

  • Predominantly gram-____
  • Strict or facultative anaerobic species
  • Maybe be ____ or motile
  • ____, red complex (Socranky 1998)

However - in health, there is MORE ____ complex. In disease there is MORE red.

A

positive
filamentous rods and cocci
nonmotile
yellow

negative
nonmotile
orange

green

41
Q

Q: In a clinically healthy periodontium, the microbial flora is largely composed of:
• gram-negative obligate microorganisms
• gram-negative facultative microorganisms
• gram-positive obligate microorganisms
• gram-positive facultative microorganisms

Q: In a healthy sulcus, which of the bacteria below are most abundant?
• Actinobacillus actinomycetemcomitans and Tannerella forsythus
• Streptococcus and Actinomyces species
• Treponema and Capnocytophaga species
• Prevotella intermedia and Porphyromonas gingivalis

Q: Early microbiologic studies of localized aggressive periodontitis (LAP) provided clear evidence of a strong association between disease and a unique bacterial microbiota dominated by:
• Tannerella forsythia
• Prevotella intermedia
• Porphyromonas gingivalis
• Actinobacillus actinomycetemcomitans (aa)

A
  • gram-positive facultative microorganisms
  • Streptococcus and Actinomyces species
  • Actinobacillus actinomycetemcomitans (aa)
42
Q

Virulence factor of Periodontopathogens

Some bacteria can…
Promote colonization
- ____

Promote host tissue destruction
- ____

Help bacterium to evade the host immune response
- ____

Degrade host immune cell
- ____

A

fimbriae or pilli
Pg, Aa collagenase
capsule
Aa leukotoxin

43
Q

Alternative Criteria for Defining Key Bacteria in Periodontal Infections

•Socransky’s alternative criteria (1997)

  • The presence of the putative pathogen in proximity to the periodontal lesions and in ____ numbers compared to either the absence of the bacteria or presence in much smaller numbers in healthy subjects
  • Patients infected with these periodontal pathogens often develop high levels of ____ in serum, saliva, and gingival crevicular fluid and may also develop a cell-mediated immune response to the putative pathogen
  • These bacteria can often demonstrate in vivo production of virulence factors that can be correlated with clinical ____
  • Experimental implantation of the organism into an animal model should lead to at least some characteristics of naturally occurring ____ disease
  • Clinical treatment that eliminates these bacteria from periodontal lesions should result in clinical ____
A
high
high
histopathology
periodontal
improvement
44
Q

Characteristics of biofilms
• ____ communities
• Metabolic ____
• ____ circulatory system
• Resist host ____
• Resist systemic or local ____ and antimicrobial agents
• Bacteria grown in biofilms communicate with each other through ____. Quorum sensing is important in the regulation of expression of specific genes.

A
dynamic
cooperation
primitive
defenses
antibiotics
quorum sensing
45
Q

Dental plaque formation
• ____ phase (Formation of the pellicle)
• ____ phase (Initial adhesion and attachment of bacteria(Rapid grow phase
• ____ maturation (Steady phase)

A

adherence
lag
colonization

46
Q

Plaque Hypotheses in the Initiation of Periodontal Disease

• Nonspecific plaque hypothesis (1960s)
- Periodontal disease results from the elaboration of noxious products by the plaque biomass, indicating that the ____ of plaque is of most importance in the initiation of disease. This hypothesis is contradicted by the finding that some patients with ____ plaque have severe periodontitis. 


• Specific plaque hypothesis (1970s)
- The pathogenic potential of plaque is dependent on the presence of, or increasing ____ of, specific microorganisms. As a result, many years have been spent trying to identify the specific pathogens associated with disease. 


• Ecological plaque hypothesis
- Putative periodontal pathogens are present in both ____ and diseased sites. A change in the pocket ____ (e.g., a change in the nutrient status) is the primary cause for the overgrowth of the putative pathogens.

A
number
little
numbers
healthy
environment
47
Q

Pathogenic Role of Calculus
• By itself, does not initiate or cause progression of periodontal disease - acts as a local ____ factor
• Acts as a biologic ____ for the development of biofilm
• May also have food and tissue debris - ____ - associated with the biofilm communities
• Materia alba is a concentration of microorganisms, ____ proteins and lipids, desquamated ____ cells, and leukocytes that is ____ adherent than dental plaque. The presence of bacteria may lead to materia alba serving as an irritant to gingival tissues. 


• Why not calculus? Calculus is calcified. It is a ____ of plaque.

A
contributing
material alba
salivary
epithelial
less
product
48
Q

Q:How much pressure should be applied when measuring the BOP?

According to Gerber, false-positive BOP results around teeth could be minimized by using a probing pressure of ____ N, and around implants a threshold pressure of ____ N could reduce false positives.

A
  1. 25

0. 15

49
Q

Q: Is probing depth a good predictor of periodontal disease?

Armitage concluded the following from studies in beagle dogs:
• Periodontal probes do not ____ measure connective tissue attachment levels.
• ____ has a significant influence on the degree of probe penetration.
• Histologic and clinical sulcus depths ____ significantly.

____ but we have to use it because it does give an idea.

A

precisely
inflammation
differ
no

50
Q

Q:Are radiographs an accurate method of diagnosing periodontal disease?

Ortman found that the unaided eye is able to detect radiographic changes when approximately ____% of the bone has been lost.

This is a tricky question that will be on an exam during your time at Penn - are radiographs a
good method to diagnose periodontitis? Furcation involvement?
- NO - you ____ to have radiographs but it is not 100% because you ____ detect early
periodontal disease.

For furcation involvement:
- for grade 1 - use a ____ probe because radiograph won’t see it bc no bone
involvement
- grade 2 - radiograph might detect it but not 100%
- grade 3 is through & through so it is easy to see a ____ on the radiograph

A

50
have
cannot

naber’s
through and through

51
Q

Q: How is periodontal abscess different from plural abscess?

Tx:
• ____ the abscess
• ____
• Possible ____

Depending on how they write the question - be careful. ANTIBIOTICS are NOT GIVEN ____.

A

drain
pain killers
antibiotics

first

52
Q

Q:What is the prognosis of a tooth that has been diagnosed with a furcation lesion?

Cobb reported that over a 15-year period, ____% of teeth with furcation lesions and only ____% of teeth without furcation lesions were lost.

Ramfjord discovered that 16 of 17 teeth extracted in 5 years during maintenance and following active treatment initially presented with ____ involvement.

A

19-57
5-10
furcation

53
Q

Q: Which of the following presents the most difficulty in performing a scaling and root planing ?

a. medial surface of maxillary premolar b. proximal surface of mandibular incisor
c. trifurcation of maxillary molars
d. distal surface of mandibular molars

Key: The anatomic features of teeth frequently limit the effectiveness and efficiency of calculus removal.

A

c. trifurcation of maxillary molars

54
Q

Q:What are the indication and contraindication for occlusal adjustment?

Indications:
\_\_\_\_ Tx 
Primary Tx of Bruxism 
Sever extrusion of \_\_\_\_ teeth
\_\_\_\_ state of the patient treatment precludes a satisfied result
Contraindications:
In conjunction with \_\_\_\_ tx. Orate tx, OGS..etc when indicate
Parafunction Habbit 
Increased \_\_\_\_ 
Traumatic Injury
A

prophylactic
malpositioned
emotional

restorative
mobility

55
Q

Q: How does orthodontics help a periodontal patient?
• ____ the teeth and helps the patient with oral hygiene
• Can improve ____ defects (decrease amount of resective surgery)
• Can force eruption to ____ the gingiva
• Can force eruption of a ____ tooth (at least 1:1 crown-to-root ratio)
• Closes open ____
• Improves adjacent tooth ____ before implant placemen

Q: What are the risks of orthodontic treatment?
• \_\_\_\_
• Root \_\_\_\_ (shortened root length)
 • Loss of attachment
• Loss of tooth \_\_\_\_
• Tooth relapse
• \_\_\_\_
A
aligns
osseous
align
cracked
embrasures
position

recession
resorption
vitality
caries

56
Q

Q:What is SRP?
Scaling is instrumentation of the crown and root surfaces of the teeth to remove ____, calculus, and staining from the teeth.

Root planing is a treatment procedure to remove ____ or surface dentin that is rough, impregnated with calculus, or contaminated with toxins or microorganisms.”

What is the difference between scaling and root planing? A lot of people get this confused.
• Scaling we remove the plaque & biofilm
• Root planing… planing refers to making a smooth surface…
We can’t do this 100% but we want to remove as much as possible to allow tissue to heal and for healthy tissue to reattach to the bone.

A

plaque

cementum

57
Q

Q: What are some factors can limit the effectiveness of SRP?
Many anatomical factors can limit the effectiveness of root instrumentation:
• ____ probing depths
• Root ____
• ____

Host response may also limit the effectiveness of root instrumentation:
• \_\_\_\_
• Pregnancy
• \_\_\_\_
• AIDS
• \_\_\_\_ 
• Blood dyscrasias
A

deep
concavities
furcations

diabetes
stress
immunodeficiencies

58
Q

Q:Is root debridement equally effective in molars and nonmolars?

Loos found that, following full-mouth root debridement, more ____ furcation sites (25%) lost probing attachment compared with ____ sites (7%) and ____ sites (10%).

Non-molars are more predictable because they only have single roots.

A

molar
non-molar
molar flat-surface

59
Q

Q: What are the consequences to patients with periodontitis who do not receive treatment?

Löe did a study on Sri Lankan laborers, who, in the absence of oral hygiene practices, presented with large amounts of plaque, calculus, and staining and widespread gingival inflammation. Using interproximal loss of attachment and rates of tooth loss, the authors identified three subpopulations:
• Individuals (approximately 8%) with ____ progression of periodontal disease
• Individuals with ____ progression of periodontal disease (approximately 81%)
• Individuals with no ____ (approximately 11%) of periodontal disease beyond gingivitis

A

rapid
moderate
progression

60
Q

Q: What are the critical probing depth?

Using a split-mouth design, Lindhe et al treated 15 patients with moderately advanced periodontal disease using SRP in combination with a modified Widman flap procedure on one side and SRP only on the contralateral side. The study found the following critical probing depths:

  • 2.9 mm: Attachment loss occurred in pockets < 2.9 mm when ____ was performed
  • 4.2 mm: Attachment loss occurred in pockets < 4.2 mm if ____ were performed”

When pocket is <3mm we DO NOT DO ____ because you will cause attachment loss and traumatize the tissue.
When the pocket is only 4 - you do not do ____ for the same reason.
When the pocket is >5mm it’s safe to do ____.

A
SRP
SRP and surgery
SRP
surgery
surgery
61
Q

Q: What is done during the maintenance visit?

What is the difference between prophy & maintenance?
• Prophy = ____ patient

• Maintenance = patient previously had ____, treated, cured and now you are
maintaining the results
◦ These patients CANNOT return to a diagnosis of “____”
◦ You cannot be cured from periodontitis - you can be treated & the disease is
____.
‣ Similar to diabetes… you can’t cure diabetes but you can be well maintained.

A

healthy
disease
gingivitis
maintained

62
Q

Side Effect of the Antibiotics

Tetracycline (Minocycline, Doxycycline)
Type: \_\_\_\_
Spectrum: \_\_\_\_
Drug interaction/side effect:
• Should not take with \_\_\_\_
• \_\_\_\_ pill will be less effective
• Not for \_\_\_\_ dysfunction patient
Metronidazole
Type: \_\_\_\_
Spectrum: \_\_\_\_
Drug interaction/side effect:
• No \_\_\_\_
• Increase the effect of the \_\_\_\_
A
bacteriostatic
broad. gram (+) and gram (-)
warfarin
birth control
renal

bactericidal
obligate anaerobes
alcohol
warfarin

63
Q
Side Effect of the Antibiotics
Amoxicillin
Type: \_\_\_\_
Spectrum: \_\_\_\_
Drug interaction/side effect: 
Can make \_\_\_\_ less effective
Clindamycin
Type: \_\_\_\_
Spectrum: \_\_\_\_
Drug interaction/side effect:
• \_\_\_\_
• Do not use in \_\_\_\_ transplant patient
A

bactericidal
broad. anaerobic gram (+) and gram (-)
effective

bacteriostatic
gram (+) and gram (-)
pseudomembranous colitis
kidney

64
Q

____: inhibits
____: kills bacteria

A

bacteriostatic

bactericidal

65
Q

The difference between doxycycline & tetracycline
• Doxy belongs to ____, which is a big family.
• Doxy is a ____ generation of tetracycline which doesn’t have the same side effects.
◦ Can take doxy while ____ … meanwhile tetra will cause ____ of teeth? Baby teeth?
◦ Both have ____ (his discussion of this was unclear but google says both)

A
tetracycline
new
pregnant
staining
photosensitivity
66
Q

Sequencing of Antibiotic Therapy

  1. Initial periodontal therapy should include thorough ____ root debridement followed by ____ access if needed
  2. ____ may be prescribed on the basis of the clinical need for further treatment, the findings of microbiological testing, and the medical status and current medications of the patient.
  3. The clinical response should be evaluated ____ months after completion of the ____ therapy.
  4. After resolution of the periodontal infection, the patient should be placed on an individually tailored maintenance program. ____ plaque control in the supportive periodontal therapy phase may help prevent recolonization by putative periodontal pathogens.
A
mechanical
sugrical
antibiotics
1 to 3
mechanical
supragingival
67
Q

Q: When should systemic antibiotics be prescribed ?
• When there is an active ____
• As antibiotic ____
• ____ grafting procedure
• To treat aggressive ____
• ____ surgery can’t be proceed for any reason
• Recurrent or refractory periodontitis due to the persistent ____
pathogens and possibly weakened host resistant

A
infection
prophlyaxis
perio
periodontitis
perio
sub gingival
68
Q

Q: Which patients would benefit the most from systemic antibiotics?
A: Irrespective of the diagnosis, patients with severe forms of periodontitis seem to
benefit from adjunctive systemic ____.

Q: Which antibiotics should be used?
A: Given the consistency of results of dozens of randomized clinical trials conducted across the globe, the combination ____ should be the antibiotics of choice to treat periodontal diseases.
However, the literature lacks studies with head-to-head comparisons between different antibiotics.

A

MTZ + AMX

amoxicillin and metronidazole

69
Q
Questions
• What are the risks of systemic antibiotics uses? Answer:
• \_\_\_\_ reactions
• Superinfection
• \_\_\_\_ effects 
• Drug interactions
• Patient \_\_\_\_
• BacterialResistance
A

allergic
toxicity/side
compliance

70
Q

Q: When extensive SRP must be performed, the best approach would be:

a. Perform everything in a ____ appointment
b. A ____ of appointment set up

A

single

series

71
Q

Q: To date, the ADA has accepted two agents for treatment of gingivitis, these are:
• Prescription solution of ____ digluconate oral rinse
• Prescription solution of ____ rinse
• ____ essential rinse
• nonprescription solution of ____ oral rinse

Substantivity: The ability of drugs to ____ onto and bind to soft and hard tissue

SUBSTANTIVITY IS SEEN ON BOARDS EVERY YEAR.
• ____ has a very good substantivity.
◦ Patients should rinse 2x day. It stays a long time in your mouth.
‣ INHIBITS THE ____ OF BACTERIA does not kill.
‣ ^so its ____, not bactericidal

A
chlorhexidine
tetracycline
nonprescription
penicillin
absorb

chlorohexidine
growth
bacteriostatic

72
Q

Maintenance

Phase I -> ____ -> phase ____ (maintenance) phase ____ (perio) or phase ____ (restorative)

phase II -> phase ____

A

reevaluation
IV
II
III

III

73
Q

Q: If there are residual pocket, what option do I have?
Re-evaluate every ____ weeks to see if more SRP is required.
Can do ____, surgical approach or nothing.
• We will talk about surgical approach in a couple of months.

A

6

SRP

74
Q

Arrestin (Minocycline) is used at Penn.
• Studies show that it is very helpful in decreasing ____ - even in smokers.
• We don’t use it all the time because Arrestin can increase bacterial ____.

TAKE A LOOK AT THE CHARTS

A

inflammation

resistance

75
Q

Host Modulation Therapy

We sometimes use bisphosphonates to inhibit osteoclasts but ____ is an issue.

A

MRONJ

76
Q

Q: What is cascade of leading bone loss

  1. ____-stimulated lymphocytes (B/T cells)
  2. Receptor activation of ____ axis
  3. Increase in the ____ ratio and protein production
  4. ____ are stimulated to osteoclasts and maturation of the osteoclasts
  5. ____ loss
A
antigen
NFkB (RANK)-RANKL-OPG
RANKL-OPG
macrophages
bone
77
Q

Q: Describe the relationship between diabetes and inflammation.

C reacting protein is looked at to quantify ____. When it is elevated, it means that some part of your body has uncontrolled inflammation.

A

inflammation

78
Q

Periodontal infection ->
Cardiovascular disease ->

  • ____ (cytokine)
  • CRP
  • ____ responses
  • bacteremia
A

inflammation

immune