periodontal microbiology Flashcards
Biofilm development stages
- adhesion
- colonisation
- accumulation
- complex community
- dispersal
P Gingivalis virulence factors
- host cell tissue adherence and invasion
- elaboration of proteases
- endotoxin
- capsular polysaccharide
- tissue toxic metabolic by-products e.g. ammonia
how does p gingival manipulate host defences?
biofilm
ginigpains
induction of tissue destruction
subversion
How gingipains manipulate host defences
- degradation of innate receptors
- degradation of cytokines
Periodontal disease systemic implications
- increased risk of cardiovascular disease
- suggested increased risk of rheumatoid arthritis
- up to 6 fold increased risk of diabetes
Periodontal disease systemic implications
- increased risk of cardiovascular disease
- suggested increased risk of rheumatoid arthritis
- up to 6 fold increased risk of diabetes
important microbes in gingivitis
actinomyces
prevotella intermedia
bacteroides
fusobacterium nucleatum
periodontitis microbes
- P. gingival
- T. forsythia
- T. denticola
- p. intermedia
P gingival features
gram negative bacteria
non-motile rod
strict anaerobe
black pigmentation
Periodontal disease - systemic implications
increased risk of cardiovascular disease
increased risk of diabetes up to 6 fold
suggested increased risk of rheumatoid arthritis