perio risk for systemic disease

Question 1

stages of acute phase reaction

Answer 1

triggering factor
local reaction
mediators
secondary systemic reaction

Question 2

examples of triggering factors for acute phase reaction

Answer 2

infection, necrosis, surgery neoplasia, radiation

Question 3

examples of local factors in acute phase reaction

Answer 3

macrophages, fbroblasts, endothelial cells

Question 4

examples of mediators of the acute phase reaction

Answer 4

TNF-alpha, IFN-gamma, IL-1, IL-6 (cytokines)

Question 5

secondary systemic reaction of acute phase reaction cascade

Answer 5

fever and leukocytosis, complement activation, serum glucocorticoid increase, altered synth of acute phase proteins

Question 6

important acute phase proteins and their actions

Answer 6

complements (opsonization, lysis and chemotaxis (CTX))
protease inhibitors (alpha2 macroglobulin)
C reactive protein (opsonization)
fibrinogen (coagulation CTX)
plasminogen (degrade clots)

Question 7

findings of PD in relation to AVD

Answer 7

there is an association but not causal

perio therapy can result in reduced systemic inflammation and improve endothelial fcn

Question 8

findings of PD in relation to PTB and LBW

Answer 8

modest association but perio therapy doesn’t appear to sig. reduce overall rates

Question 9

type 1 diabetes is caused by

Answer 9

autoimmune destruction of pancreatic beta cells resulting in hypo production of insulin (insulin dependent diabetes)

Question 10

type 2 diabetes is caused by

Answer 10

insensitivity to insulin by target tissues (non-insulin dependent)

Question 11

relationship btwn type 2 diabetes and PD

Answer 11

seems to be correlation w/ HbA1c (present in higher levels w/ perio which decreases w/ SRP)

Question 12

findings w/ PD and pneumonia

Answer 12

association w/ hospital acquired pneumonia

Question 13

findings w/ PD and COPD

Answer 13

not conclusive but ppl w/ poor oral hygiene have an inc. risk of dev. chronic resp. disorders and ppl w/ COPD have more attachment loss