Perio III 4/23/14 Final exam Flashcards
Focal Theory of Infection
infections in oral cavity having an adverse effect on other organs/tissues
Periodontitis &
Coronary Heart Disease
25% of those with both will die of CHD (risk esp high for men)
Periodontitis &
cardiovascular/stroke
mechanisms
Perio infection -> systemic circulation -> coronary & carotid artery-> atheroma dev.
Perio infection -> production of mediators-> systemic circulation -> atheroma dev.
Chlamydia Pneumonia Cytomegalovirus actinobacillus actinomycetemcomitans tanarella forsythensis porphyromonas gingivalis prevotella intermedia
bacteria ID’ed in atheromatous plaques in Hs carotid arteries
Do well controlled diabetics need antibiotic prophylaxis?
not in most cases
Does nonsurgical periodontal therapy improve glycemic control in a diabetic with periodontitis?
no
What does lower glycosylated hemoglobin in a diabetic with periodontitis?
Combination of mechanical therapy & systemic doxycycline:
~Debridement (SRP)
~2 wks of low dose doxycycline
~Frequent maintenance
When is the best time to give perio Tx for a diabetic?
before or after periods of peak insulin activity
Periodontitis and pregnancy
possible risk for pre-term birth
60-70% get gingivitis
90% heart murmurs
50% inc. in CO
when is the best time to treat a pregnant women with gingivitis?
2nd trimester
inform pt and maintain good OH
(estrogen/progesterone inc. partly to blame)… 0-0 anaerobic bacteria: Prevotella intermedia)
Does perio Tx significantly alter risk of pre-term delivery?
no
local antimicrobial delivery of Tetracycline hydrochloride
periodontal fiber therapy: 12.5 mg/fiber -10 days
Actisite
local antimicrobial delivery of Chlorhexidine- 2.5 mg
*pockets ≥ 5mm
*broad spectrum
*gelatin = carrier, no refrigeration
*decreased pockets
~mild-moderate sensitivity during 1st week
~continue toothbrushing & regular diet
~avoid flossing for 10 days
Perio Chip ($16/chip... 1 tooth) provided significantly greater improvement with this adjunct when used with SRP
local antimicrobial delivery of Doxycycline- 8.5% *pockets ≥ 5mm *controlled release for 7 days *decreased pockets, improved CAL & bop Tx chronic periodontitis
Atridox ($45/ syringe… 6 teeth)
significantly reduced anaerobic bacteria without dev. of antibiotic resistant bacteria.
local antimicrobial delivery of minocycline powder (microspheres)
*25% more shift from PD 7mm to ≤5mm p 9mo
Arrestin
$14 per cartridge(tooth)
same contraindications as the systemic minocycline
what local antimicrobial delivery did not consistently show more effective than just SRP alone?
Elyzol
- 25% Metronidazole
- for PD ≥ 5mm
- anaerobic bacteria (bacteriocidal)
Emdogain
7 indications for controlled antimicrobial delivery
local
- PD ≥ 5mm
- BOP
- Where esthetics is a concern & Sx may be contraindicated (uncontrolled diabetic, elderly, …)
- Not responding to SRP
- Dental phobic pt
- Refractory Periodontitis (aka recurrent)
- Medically compromised patients (Perio Sx contraindicated)
The only FDA approved oral, systemic Tx for chronic periodontitis that suppresses activity of destroying enzymes.
For maintenance pt with refractory/recurrent periodontitis & smokers trying to quit
Periostat: 20 mg capsule of doxycycline ($60/mo)
2x/day- 1 hr before meals with adequate fluids
max efficacy 9 mo… min efficacy 3 mo
The following are oral manifestations of what?
Severe gingival inflammation
Acute gingival or periodontal abscesses
Rapidly advancing periodontal disease
uncontrolled diabetes mellitus
Why re-evaluate after initial Tx?
Check lesion elimination (shallower pockets)
check if tissues are firmer
give time for pt education & comfort
purpose of Phase II (surgical) Tx
improve Px of teeth & their replacements
Improves esthetics
Advantages vs. disadvantages of local chemotherapeutics
*more concentration
*fewer side effects
*sustained delivery
*pt compliance
x More chairside time
x more expensive
x no effect on bacterial reservoirs
side effect of pseudomonas colitis from the toxin produced by Clostridium difficile
Tetracyclines= doxycycline, minocycline, etc..
Clindamycin (cleocin)
Penicillins = penicillin VK, amoxicillin, augmentin
Bacteriostatic via protein synthesis -> G+/- 2 types of this drug's absorption may be lowered by: -antacids (NaHCO3) -laxatives (Mg, Ca, Al) -antidiarrhea -food/diary -Fe, Zn Other 1 Tx refractory periodontitis x pseudomonas colitis side effect
Tetracycline & minocycline
Doxycycline
Bacteriostatic (some -cidal) -> G +/- anaerobes
Tx refractory periodontitis
x pseudomonas colitis side effect
x diarrhea, abdominal pain, blood in stools
Clindamyacin
Bacteriocidal via DNA syn -> obligate anaerobes Tx periodontitis/AIDS x GIT x inc. anticoagulant effect x disulfuran-like rxn
Metronidazol (flagyl)
Bacteriocidal via CW syn -> rapidly growing bacteria
Tx perio abscess
x pseudomembranous colitis
x allergic rxn
Penicillins (pen VK, amoxillin, augmentin)
Amoxicillin advantage over penicillin VK
better absorbed (95% vs. 65%) longer serum 1/2 life (0.7-1.4 vs. 0.5) may take with food
Bacteriocidal via protein synthesis
Stays in the tissue 9-10 days after finishing regimen
x 1 causes upset stomach/nausea more common
The other is the alt Tx for periodontal abscess due to its better anaerobic coverage, long serum 1/2 life (1 dose/day), & pregnant category B
Erythromycin (1)
azithromycin (other)
clarithromycin
These systemic drugs cause…:
Dilatin
Cyclosporine
Calcium channel blockers
hyperplastic gingiva
2 important antibiotic regimens
Amoxicillin & metronidazole
Doxycycline
Guidelines for antibiotics:
Are they necessary for most gingivitis or periodontitis?
No
Guidelines for antibiotics:
May be necessary for refractory periodontal disease which doesn’t respond to conventional therapy. What should be given? (give 4 regimens)
- Doxycycline 100 mg; 21 tabs, 2 for day 1 and then 1/day
- Amoxicillin & Metronidazole (500mg & 250 mg)
- (if allergic to penicillin) Ciprofloxacin & Metronidazole (250 mg each)
- (refractory & generalized aggressive periodontitis) Clindamycin 150 mg
Guidelines for antibiotics:
Tx for locally aggressive (juvenile) periodontitis
Doxycycline
Amoxicillin & Metronidazole (500mg & 250 mg) 22 tabs each- 2 tabs each, then 1 q 6 hrs
Guidelines for antibiotics:
List (10) systemic diseases that influences severity of periodontal disease
- Chediak-Higashi Syndrome
- Down’s Syndrome
- Papillon LeFevre Syndrome
- DIabetes
- AIDS
- Cancer
- Leukemia
- Neutropenia
- Hypophosphatasia
- Leukocyte Adhesion Deficiency
Guidelines for antibiotics:
Tx with Papillon LeFevre Syndrome
Augmentin (amoxicillin 500 mg, clavulonic acid 125 mg)
Guidelines for antibiotics:
Tx for AIDS & gingivitis
Chlorhexidine rinse
Guidelines for antibiotics:
Tx for AIDS & periodontitis (NUG, NUP)
Chlorhexidine rinse & Metronidazole