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DAOB321 > Perio > Flashcards

Perio Flashcards

1
Q

These bacteria are gram positive cocci associated with periodontal health

A

Streptococcus Sanguinis

Streptococcus Gordonii

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2
Q

These are gram positive rods associated with gingivitis

A

Actinomyces isrealii

Actinomycels naeslundii

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3
Q

These are gram negative bacteria associated with tissue destruction in periodontitis

A

Porphyromonas Gingivalis
Tannerella Forsythia
Treponema Denticola

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4
Q

This is a spirochete associated with periodontal tissue destruction

It is a strict anaerobe, found in large numbers where?

A

Treponema Denticola

At the base of pockets (attachment loss)

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5
Q

This is a gram negative, anaerobic rod associated with tissue destruction in periodontitis

Healthy children and adolescents harbor none of it

Most patients have a single clone

Stronly correlated with periodontits, multiple virulence factors

A

Porphyromonas Gingivalis

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6
Q

This is a gram negative anaerobic rod strongly associated with periodontitis and possibly involved in its initiation

A

Tanerella Forsythia

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7
Q

This bacteria is a gram negative coccobacillus

What is it strongly associated with some cases of?

Some strains produce a toxin that kills neutrophils and macrophages

A

Aggregatibacter actinomycetemcomitans

Localized Aggressive Periodontitis

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8
Q

This cytokine stimulates osteclast activity, resulting in bone resorption.

Also induces breakdown of collagen in gingiva, periodontal ligament and alveolar bone

A

Cytokine IL-1

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9
Q

This cytokine stimulates bone resorption and inhibits bone formation

A

IL-6

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10
Q

This cytokine stimulates connective tissue destruction and bone resportion

A

IL-8

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11
Q

So IL-1, IL-6, and IL-8 stimulate bone resoprtion, among other things

A

!

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12
Q

This cytokine stimulates bone resorption and induces the breakdown of collagen matrix in the gingiva periodontal ligament, and alveolar bone

A

Cytokine TNF-alpha

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13
Q

The molecule stimulates MMP secretion and stimulates bone resorption

A

Prostglanding E2 (PGE2)

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14
Q

These molecules induce breakdown of collagen matrix in the gingiva, periodontal ligament, and alveolar bone

A

Matrix Metalloproteinases (MMPs)

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15
Q

This system provides a second line of defense when bacterial pathogens invade immune cells

When activated, they stimulate direct killing (lysis) of bacteria via MACs, opsonization of pathogens, and recruitment of additional cellular defenders

A

The complement system

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16
Q

Phagocytes like PMNs and later Macrophages are recruited to the periodontal lesion and part of the innate immune response

They are recruited by several means, including:

The alternate pathway of this system, molecules like C3a, C5a, vasodilation, expression of ICAM-1

These molecules on phagocytes that recognize macromolecules unique to bacteria, like LPS for gram positive and lipotechoic acid for gram positive bacteria, allowing for activation and proliferation

This molecule that is chemotactic for PMNs and macrophages

This molecule that is chemotactic for the B cell

A

Complement Activation

Toll Like Receptors

fMet-Leu,Phe

C5a

17
Q

LPS is a TLR found where?

A

Gram negative bacteria

18
Q

Lipoteichoic acid is a TLR found where?

A

Gram positive bacteria

19
Q

Acute inflammation is characterized by:

A

PMNs

20
Q

Chronic inflammation is characterized by:

A

Macrophages, B cells, plasma cells

21
Q

Healing is characterized by:

A

Fibroblasts, endothelial cells, epithelial cells

22
Q

If chronic inflammation is allowed to persist, you have persistance of inflammatory cells and cytokines leading to tissue destruction, termed

A

Friendly Fire

23
Q

This is an acute phase response protein that is part of the innate immune system

A

C-reactive Protein

24
Q

These two molecules are part of the INNATE immune system and the alternate complement pathway

A

C3a, C5a

25
Q

Acid hydrolases, elastase, proteases are part of innate immunity and are associated with these cells

A

PMNs

26
Q

Cytokines IL-1, 6, 8, TNF-alpha, PGE 2, are associated with this cell of innate immunity

A

Macrophages

27
Q

Toll like receptors are innate or adaptive?

A

Innate

28
Q

B cells and T cells are innate or adaptive?

A

Adaptive

29
Q

The classic complement pathway is innate or adaptive?

A

Adaptive

30
Q

What molecules of adaptive immunity do T cells secrete?

A

Cytokines IFN-gamma, IL2, IL6

31
Q

These helper T cells are pro-inflammatory, they secrete IFN gamma

A

Th1 cells

DAOB321 (4 decks)

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