Perinatal Psychiatry Flashcards

1
Q

red flag presentations in perinatal period?

A

recent significant change in mental state or emergence of new symptoms
new thoughts or acts of violent self harm
new and persistent expressions of incompetency as a mother or estrangement from their baby

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2
Q

admission to a mother and baby unit should always be considered where a women presents with what?

A
rapidly changing mental state
suicidal ideation (particularly of a violent nature)
significant estrangement from baby
pervasive guilt or hopelessness
beliefs of inadequacy as a mother
evidence of psychosis
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3
Q

who can admit to a mother and baby unit?

A

only a psychiatrist

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4
Q

important parts of screening for mental health problems

A

at booking

  • history of mental health problems, treatment and family history
  • identify risk factors
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5
Q

risk factors for perinatal mental health problems?

A
young 
single
domestic issues
lack of support
substance abuse
unplanned pregnancy
pre-existing mental health problem
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6
Q

screening questions which should be asked at every appointment?

A

any feeling down, depressed or hopeless in last month?
bothered by having little interest or pleasure in doing things in last month?
is this something you feel you need help with?

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7
Q

psychiatry team must see any woman with any of which features?

A

psychosis
severe anxiety, depression, suicidal, self neglect, self harm
symptoms with significant interference with daily functioning
history of bipolar or schizophrenia history of puerperal psychosis
psychotropic medications
if any moderate mental illness in late pregnancy or early post partum
mild-mod illness but 1st degree relative with bipolar or puerperal psychosis
previous in patient admission to mental health unit

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8
Q

how does pregnancy interact with pre-existing mental health problems?

A

pregnancy is generally not protective against mental illness
bipolar
- high relapse rate post-natally
eating disorders
- may improve during pregnancy but risks during pregnancy
antenatal depression
- 68% relapse if mother stops meds

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9
Q

risks in pregnancy if eating disorder present?

A
IUGR
prematurity
hypokalaemia
hyponatraemia
metabolic alkalosis
miscarriae
premature delivery
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10
Q

how is depression managed during pregnancy?

A

if mild and on treatment - can consider stopping treatment and referring for psychological treatment
mild-mod = GP managed
severe = referral to psychiatry

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11
Q

features of normal baby blues?

A
occurs in 50%
brief period of emotional instability
tearful
irritable
anxiety
poor sleep
confusion
usually 3-10 days
self limiting
managed with support and reassurance
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12
Q

features of puerperal psychosis?

A
early
- sleep disturbance 
- confusion
- irrational ideas
later
- mania
- delusions
- hallucinations
- confusion

usually present within 2 weeks of delivery

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13
Q

risk factors for puerperal psychosis?

A

bipolar
previous episode
1st degree relative with history

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14
Q

how is puerperal psychosis managed?

A

medical emergency
needs admission to specialised mother baby unit same day
managed with antidepressants, anti-psychotics, mood stabilisers and ECT if needed

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15
Q

long term risks of puerperal psychosis?

A

80% 10 year recurrence

25% go on to develop bipolar disorder

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16
Q

what is post-natal depression?

A

episode of depression (more severe than baby blues) following child birth

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17
Q

features of post-natal depression?

A
onset 2-6 weeks, lasts weeks to months
tearfulness
irritable
anxiety
lack of enjoyment 
poor sleep
weight loss
can present as concerns re baby
effects on bonding, child development, miscarriage risk, suicide
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18
Q

how is post-natal depression managed?

A

screened for routinely
mild-mod = self help, counselling
mod-severe = psychotherapy and antidepressents, admission if needed

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19
Q

risks to baby in untreated depression?

A

low birth weight (not massive, associated with severity of depression)
pre-term delivery
adverse childhood outcomes (emotional/conduct problems, ADHD)
poor engagement/bonding with child (causes reduced infant learning and cognitive development)

20
Q

main points in planning pregnancy in someone with pre-existing mental health disorder?

A

antenatal monitoring and support
contingency plans - consider advance directive in case capacity becomes compromised
place of delivery
postnatal management and support

21
Q

important considerations when prescribing in pregnancy?

A

use lowest dose monotherapy (avoid depot)
be aware of altered pharmacokinetics in pregnancy
increase screening of foetus (cardio and growth etc)
risks and benefits can differ between 1st and 3rd trimester and breastfeeding

22
Q

risks of stopping teratogenic drugs abruptly?

A

stopping after pregnancy is confirmed may not remove the risk of malformations (e.g valproate causes neural tube defects but neural tube closes at week 4 so damage is already done)
there are also risks from stopping drug abruptly alone

23
Q

breastfeeding advice when taking medication?

A

encourage breastfeeding unless specifically contra-indicated

24
Q

main drug issue in 1st vs 3rd trimester?

A
1st = teratogenicity
3rd = risk of neonatal withdrawal
25
Q

main risk of drug in breastfeeding?

A

medication passing into breastmilk
but exposure in breast milk is usually less than in utero therefore in general, there is no need to stop a drug that was used during pregnancy

26
Q

first line antidepressants in pregnancy?

A

SSRI

  • sertraline gets into the placenta the least
  • fluoxetine is thought to be the safest
27
Q

risksof SSRI in pregnancy?

A
persistent hypetension of newborn
lower birth weight
increased early birth
post partum haemorrhage
increased congenital cardiac..... problems in paroxetine
28
Q

other antidepressatns in pregnancy and their risks?

A

tricyclics - dont really cause big problem, may cause mild withdrawal
venlafaxine - less evidence but may cause cardiac problems and cleft palate or neonatal withdrawal
limited evidence of risks of mirtazapine

29
Q

risks of antipsychotics in pregnancy?

A

risk of gestational diabetes (esp with 2nd generation)
reduced fertility due to raised prolactin levels in people taking before pregnancy (esp 1st generation)
appear to be generally safe in pregnancy and dont harm baby

30
Q

best antpsychotics?

A

generally olanzapine and quetiapine

best to be kept on medication

31
Q

risks of bipolar in pregnancy?

A
induction or C section
pre-term delivery
small babies
no increase in vongenital malformations
......
32
Q

use of mood stabilizers in pregnancy?

A

no safe mood stabilisers
valproate and carbamazepine are most teratogenic and can cause neural tube defects and should be avoided
lamotrigine is less bad than other anti-convulsants

33
Q

lithium risk?

A

should avoid in pregnancy is possible
known association to ebstein’s abnormality
ahould monitor regularly with ECHO and enhanced US

34
Q

lithium use?

A

consider slow reduction pre-conception
be aware of dose changes in 3rd trimester
consider re-introduction immediately post-partum

35
Q

recommendatinos for bipolar in pregnancy?

A

high relapse rate if medications stopped suddenly
aim to switch to a safer antipsychotic (e.g quetiapine)
valproate and carbamazepine should be avoided
increased monitoring if lithium is required
may need to consider ECT

36
Q

management of anxiety in pregnancy?

A

SSRI = first line
benzodiazepines generally avoided but not teratogenic (but can cause 3rd trimester risk of floppy baby)
zopiclone also has evidence of risk

37
Q

what type of drugs are regarded as safe in breastfeeding?

A

drugs with RID (relative infant dose) <10%

all psychotropics are secreted in breastmilk

38
Q

prescribing in breastfeeding?

A

lowest possible dose
avoid combinations of drugs
times doses to feeds (i.e give dose before longest break between feeds)
generally if a drug is safe in 3rd trimester, its safe in breastfeeding

39
Q

recommendations in breastfeeding?

A
antidepressants
- SSRI 1st line
- no need to change from drug used in pregnancy
antipsychotics
- olanzapine, quetiapine best evidence but othes probably OK
- avoid clozapine (agranulocytosis risk)
mood stabilisers
- antipsychotics
- avoid lithium and valproate
40
Q

risks in substance abuse in pregnancy?

A
nutritional deficiency
HIV, Hep B/C
VTE
STIs
endocarditis/sepsis
poor venous access
opiate tolerance/withdrawal
drug overdose/death
risk of domestic abuse and suicide
IUGR, stillbirth, SIDs, pre-term labour
41
Q

alcohol recommendations in pregnancy?

A

RCOG suggests abstinence but no evidence that 2 units/week is detrimental

42
Q

risks to pregnancy in alcoholism?

A
risks of miscarriage
foetal alcohol syndrome 
withdrawal
risk of wernicke's encephalopathy (20% die)
korasfoff syndrome (permanent)
43
Q

features of foetal alcohol syndrome?

A
facial deformity
lower IQ
neurodevelopmental delay
epilepsy
hearing
heart and kidney defects
44
Q

risks to pregnancy in cocaine, amphetamine and ecstsy use?

A
death via stroke and arrhythmia
teratogenic
- microcephaly, cardiac, GU and limb defects
pre-eclampsia
abruption
IUGR
pre-term labour
miscarriage
developmental delay
SIDS
withdrawal
45
Q

risks of opiates and nicotine in pregnancy?

A

opiates cause maternal death, neonatal withdrawal, IUGR, SIDS and still birth
nicotine causes miscarriage, abruption, IUGR, stillbirth and SIDs

46
Q

antenatal care in substance abuse?

A

consider methadone programme
child protection and social work referral
smear history
breastfeeding (not if >8 units alcohol per week, HIV, cocaine)
labour plan re analgesia and labour ward delivery
early IV access
postnatal contraception plan