Peri-optimistic thinking you’ll get them right Flashcards
1
Q
How many days prior to OT do you cease: Ticagrelor? Warfarin? Dabigatran? Apixaban?
A
Clopidogrel = 7 Warfarin = 5 Dabigatran = 5 Apixaban = 3
2
Q
Which 4 patients require bridging on Warfarin?
What does bridging Heparin start and cease?
INR before neuroaxial puncture vs OT?
A
Bridging = mechanical heart valves, thrombotic event in last 6 months, thrombophilia disease & CHADS score 5-6 Heparin = starts day 2 pre-op, last dose day prior INR = <1.2 for puncture, <1.4 for OT
3
Q
MOA of clopidogrel?
How many days prior to OT do you cease?
A
Selectively inhibits the binding of ADP to its platelet receptor, inhibiting platelet aggregation
Cease = 7 days
4
Q
Do prasugrel, clopidogrel, ticlopidine, ticagrelor all have the same MOA?
What is it?
How does Ticagrelor differ?
A
YES! Inhibit ADP binding to platelets
Ticag = it is reversible as it binds to a differ ADP site
5
Q
How long prior to OT do you hold:
Heparin?
LMWH?
Heparin infusion? what do you check post-infusion?
A
Heparin = am dose LMWH = 12hrs in renal function normal or 24hrs if not/given a therapeutic dose Infusion = 4 hours, check APTT if renal impairment
6
Q
What clinical triad is associated with coagulopathy?
A
Hypothermia, hypotension and acidosis
