Pentose Phosphate And Uronic Acid Pathways Flashcards
What is the Pentose Phosphate Pathway?
An alternative minor pathway for glucose oxidation that neither produces ATP nor utilizes it, aiming to produce NADPH+H+ and ribose.
Where is the Pentose Phosphate Pathway located within the cell?
Cytosolic.
In which tissues is the Pentose Phosphate Pathway actively found?
Liver, adipose tissues, lactating mammary gland, RBCs, suprarenal cortex, thyroid, and testis.
Which tissues do not have active Pentose Phosphate Pathway?
Non-lactating mammary gland and skeletal muscles.
What are the key regulatory enzymes of the Pentose Phosphate Pathway?
Glucose-6-phosphate dehydrogenase and 6-phospho-gluconate dehydrogenase.
What activates the Pentose Phosphate Pathway?
Fed state, glucose, insulin, thyroxine, and NADP.
What inhibits the Pentose Phosphate Pathway?
Starvation, diabetes mellitus, and high NADPH.H+/NADP ratio.
What is one function of the Pentose Phosphate Pathway?
Production of pentoses.
What are pentoses used for?
- Nucleic acids
- Coenzymes synthesis
- Synthesis of certain vitamins.
What is another function of the Pentose Phosphate Pathway?
Production of NADPH.H+.
Which pathways require NADPH produced by the Pentose Phosphate Pathway?
- Fatty acid synthesis
- Cholesterol synthesis
- Synthesis of non-essential amino acids.
What is Favism?
A hereditary disease linked to G6PD deficiency, primarily affecting males.
What does G6PD catalyze?
The first step in the Pentose Phosphate Pathway, producing NADPH.
How does G6PD deficiency affect detoxification?
It diminishes NADPH production, inhibiting detoxification of H2O2.
What are the consequences of G6PD deficiency?
Cellular damage, lipid peroxidation, and breakdown of erythrocyte membranes.
