Penile and Urethral Disorders Flashcards

1
Q

What is the corpus cavernosum? Corpus spongiosum?

A
  • corpus cavernosum: 2 columns of tissue that run along side of penis that helps w/ erections
  • corpus spongiosum: column of sponge like tissue that runs along front and ending at glans, urethra runs through the spongiosum
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2
Q

What is urethritis? Causes?

A
  • an inflammation of the urethra
  • females greater than males
  • Causes:
    gonorrhea
    chlamydia
    HPV
    herpes simplex
    idiopathic
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3
Q

Sxs of urethritis in males and females?

A
- males:
dysuria
itching or burning at the meatus
hematuria/hematospermia
urethral d/c
- females:
frequency
dysuria
SP discomfort
d/c
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4
Q

Dx and tx of urethritis?

A
  • dx:
    UA and culture
    NAATs
-tx:
azithro 1 g PO single dose
doxy 100mg bidx 7 days
- alt:
erythromycin 500mg PO qidx 7days
levofloxacin/cipro 500 mg once dailyx 7 days 
- tx partner
- use condoms
avoid irritants
- NSAIDs 
- avoid acidic foods
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5
Q

What is a urethral stricture?

A
  • a fibrotic band of tissue that renders the normal compliant urethral lumen inelastic
  • narrowing of urethra w/ slowing of urine
  • 2 types:
    anterior: begins at bulbar urethra and ends at meatus (straddle injuries, falling off of a bike)
    posterior: involves membranous and prostatic urethra
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6
Q

Etiology of urethral strictures?

A
  • trauma:
    anterior urethra - straddle injuries, penetrating injuries
    posterior urethra - urethral disruption from pelvic fracture
  • iatrogenic: catheterization, surgical
  • infection:
    gonococcal/chlamydia
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7
Q

Presentation and dx of urethral strictures?

A
- presentation:
obstructive urinary sxs - 
slow stream 
decreased caliber
post-void dribbling
- dx:
catheter (if able to cath - doesn't have stricture)
cystoscopy
RUG
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8
Q

Tx of urethral stricture?

A
  • urethral dilation
  • DVIU
  • urethroplasty
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9
Q

What is a meatal stenosis? Causes? Sxs? dx? Tx?

A
  • narrowing of opening of urethra at tip of penis
  • more common in males
  • Causes:
    swelling and irritation after newborn circ, idiopathic
  • sxs:
    spraying of stream
    bed wetting
    dysuria
  • dx:
    physical exam
  • Tx:
    meatonomy
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10
Q

What is hypospadius? How common is this? Presentation?

A
  • congenital defect in which opening of urethra is on underside of penis
  • 1/300 boys
  • 14% siblings
  • 8% in offspring
  • occurs b/t glands and penile scrotal jxn
  • presentation:
    spraying of urine
    having to sit down to void
    foreskin makes penis lool like it has a hood
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11
Q

Dx and tx of hypospadius?

A
  • dx: made usually at time of birth w/ PE
  • tx:
    surgical repair (4-18 months)
    magpi
    snodgrass (complications - meatal stenosis, fistula)
  • don’t circumcise - need skin to repair
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12
Q

What is Balanitis? Causes? Presentation?

A
  • inflammation of glans penis
  • uncircumcised men w/ poor hygiene most affected
  • 3-11% of males
  • causes:
    infectious
    non-infectious
  • presentation:
    pain
    irritation
    itching/burning
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13
Q

PE, dx and tx of balanitis?

A
- PE:
erythema/edema
D/C
ulceration
- dx:
culture d/c
wet mount
KOH
-tx:
retraction of foreskin/wash w/ soap and water
bacitracin if bacterial infection suspected
- topical clotrimazole for candidal infection
- circumcision - especially if recurrent
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14
Q

What is Phimosis? Causes? Complications?

A
  • inability to retract foreskin over glans due to narrowing, constriction, or adhesions
  • in kids phimosis may resolve on own
  • 1-5% of male by age of 16
  • causes:
    balanitis
    poor hygiene
  • complications:
    balanitis
    paraphimosis
    voiding problems
    penile carcinoma
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15
Q

Presentation and tx of phimosis?

A
- presentation:
erythema
itching
d/c
pain w/ erection and intercourse
- tx:
betamethasone cream 0.05% bid
circumcision (alt)
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16
Q

What is paraphimosis? Tx?

A
  • retracted foreskin becoming trapped proximal to glans resulting in edema, inflammation, and pain
  • untx can lead to ischemia of glans and eventual gangrene
  • tx:
    firm compression and manual reduction of foreskin, circumcision
17
Q

What is Peyronie’s Disease? Cause?

A
  • curvature of penis, particularly during erections
  • fibrosis and plaque formation of tunica albuginea
  • usually affects men aged 40-70 yo
  • cause:
    vascular trauma
    injury to penis
18
Q

Acute and chronic phase of peyronie’s disease?

A
  • acute: first 18-24 hrs - includes penile pain, some curvature, penile nodule, and inflammation
  • chronic: characterized by stable plaque, penile angulation, and loss of erectile ability
19
Q

Presentation of peyronie’s disease?

A
  • penile pain
  • penile angulation
  • palpable plaque
  • indentation in shaft
  • decreased ED
20
Q

Tx of peyronie’s disease?

A
  • if dx in first 6 months:
    Vitamin E
    ibuprofen
    colchicine
 after 6 month w/ stable plaque:
-injection therapy: 
collagenase clostridiu histolyticum (Xiaflex) - men w/ palpable plaque and at least 30 degree curvature
-verapamil: weekly injections for 6 wks
- surgery
21
Q

What is ED? Prevalence?

A
  • inability to achieve or maintain an erection for satisfactory sexual performance
  • MC sexual problem in men: affect relationships, quality of life, self-esteem
  • prevalence:
    under 59: 12%
    60-69: 22%
    over 69: 30%
22
Q

Normal erectile response?

A
  • interaction b/t neurotransmitter, biochemical and smooth muscle response
  • initiated by parasympathetic and sympathetic neuronal triggers
  • integrate physiologic stimuli of penis w/ sexual perception and desire
  • nitric oxide produced from endothelial cells after parasympathetic stimuli trigger smooth muscle relaxation and arterila influx of blood
  • compression of venous return follows producing an erection
23
Q

RFs of ED?

A
  • HTN
  • smoking
  • DM
  • hyperlipidemia
  • obesity
24
Q

Dx ED?

A
  • international index of erectile fxnl questionnaire
  • fasting serum glucose
  • lipid panel
  • TSH
  • testosterone level
25
Q

Tx of ED?

A
  • 1st line: lifesyle modifications - tx HTN, exercising, diet
  • 1st line meds:
    PDE5 inhibitors -
    sildenafil (viagra) 50-100mg
    tadalafil (cialis) 5mg daily or 10-20 mg
    vardenafil (levitra) 10-20 mg
    avanafil (steward) 50-200 mg
    -SE: HA, flushing, rhinitis, abnormal vision
  • Don’t take w/ nitrates
-2nd line:
alprostadil (caverject) injection (SE: priapism)
vacuum pump device
muse 125-100-mcg intraurethrally 
- 3rd line and last:
inflatable penile prosthesis