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PCOL - 3S > PENICILLINS: NARROW SPECTRUM PENICILLINS > Flashcards

PENICILLINS: NARROW SPECTRUM PENICILLINS Flashcards

1
Q

What is the main route of administration for Penicillin G?

A. Oral (PO)
B. Intramuscular (IM)
C. Intravenous (IV)
D. Subcutaneous (SC)

A

B. Intramuscular (IM)
C. Intravenous (IV)

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2
Q

Which of the following statements about PENICILIN G’s kinetics is correct?
A. It has a short half-life
B. It is excreted primarily through the liver
C. It is absorbed quickly
D. It can cross the blood-brain barrier when meninges are inflamed

A

D.

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3
Q

Which enzyme does Penicillin G, Penicillin V and Benzathine & Procaine Pen G inhibit to prevent bacterial cell wall synthesis?
A. DNA polymerase
B. RNA polymerase
C. Transpeptidase
D. Helicase

A

Transpeptidase

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4
Q

What is the main clinical application of BENZATHINE & PROCAINE PENICILIN G?
A. Tuberculosis
B. Meningitis
C. Oropharyngeal infections
D. Syphilis

A

D

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5
Q

What is the MAIN toxicity associated with PENICILLIN G, BENZATHINE & PROCAINE PENICILIN G, PENICILIN V?
A. Nausea and vomiting
B. Liver damage
C. Rash
D. Allergy

A

D.

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6
Q

Which of the following statements about Benzathine & Procaine Penicillin G is correct?
A. It has a short half-life
B. It is administered orally
C. It can cross the blood-brain barrier at minimal inhibitory concentration (MIC)
D. It is primarily used to treat urinary tract infections

A

C. It can cross the blood-brain barrier at minimal inhibitory concentration (MIC)

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7
Q

What is the route of administration for Benzathine & Procaine Penicillin G?
A. Intramuscular (IM)
B. Intravenous (IV)
C. Oral (PO)
D. Subcutaneous (SC)

A

A. Intramuscular (IM)

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8
Q

What is the main clinical application of Benzathine & Procaine Penicillin G?
A. Tuberculosis
B. Neurosyphilis
C. Pneumonia
D. Urinary tract infections

A

B. Neurosyphilis

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9
Q

Which of the following statements about Penicillin V is correct?
A. It has low bioavailability
B. It is primarily excreted through the liver
C. It is not affected by food intake
D. It is administered intravenously

A

A. It has low bioavailability

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10
Q

What is the main route of administration for Penicillin V?
A. Oral (PO)
B. Intramuscular (IM)
C. Intravenous (IV)
D. Subcutaneous (SC)

A

A. Oral (PO)

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11
Q

What is the main clinical application of Penicillin V?
A. Tuberculosis
B. Oropharyngeal infections
C. Meningitis
D. Urinary tract infections

A

B. Oropharyngeal infections

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12
Q

Which of the following is a common toxicity of Penicillin V?
A. Liver damage
B. Nausea and vomiting
C. Rash
D. Allergy

A

D. Allergy

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13
Q

How does Penicillin G prevent bacterial cell wall synthesis?
A. By inhibiting DNA replication
B. By inhibiting protein synthesis
C. By inhibiting cell wall transpeptidases
D. By inhibiting cell membrane synthesis

A

C. By inhibiting cell wall transpeptidases

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14
Q

Which of the following is a characteristic of Penicillin G’s kinetics?
A. Short half-life
B. Rapid absorption
C. Excretion primarily through the liver
D. Slow release of the drug

A

D. Slow release of the drug

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15
Q

What is the main clinical application of Benzathine & Procaine Penicillin G?
A. Tuberculosis
B. Neurosyphilis
C. Pneumonia
D. Urinary tract infections

A

B. Neurosyphilis

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16
Q

Which of the following is a common toxicity associated with Penicillin G?
A. Liver damage
B. Nausea and vomiting
C. Rash
D. Allergy

A

Which of the following is a common toxicity associated with Penicillin G?
A. Liver damage
B. Nausea and vomiting
C. Rash
D. Allergy

17
Q

What is the route of administration for Penicillin V?
A. Oral (PO)
B. Intramuscular (IM)
C. Intravenous (IV)
D. Subcutaneous (SC)

A

A. Oral (PO)

18
Q

How does Penicillin G prevent bacterial cell wall synthesis?
A. By inhibiting DNA replication
B. By inhib iting protein synthesis
C. By inhibiting cell wall transpeptidases
D. By inhibiting cell membrane synthesis

A

C. By inhibiting cell wall transpeptidases

19
Q

Which of the following is a characteristic of Penicillin G’s kinetics?
A. Short half-life
B. Rapid absorption
C. Excretion primarily through the liver
D. Slow release of the drug

A

D.

20
Q

What is the main clinical application of Benzathine & Procaine Penicillin G?
A. Tuberculosis
B. Neurosyphilis
C. Pneumonia
D. Urinary tract infections

A

B

21
Q

What is the route of administration for Penicillin V?
A. Oral (PO)
B. Intramuscular (IM)
C. Intravenous (IV)
D. Subcutaneous (SC)

A

A

22
Q

PKINETICS:

● Long half-lives
● The drug is released slowly
● Cross the blood-brain barrier when
meninges are inflamed
● Excreted by the kidneys; dose
adjustment may be required

A

Penicillin G

23
Q

PKINETICS:

● Delayed absorption
● Can cross the BBB at MIC
● Low bioavailability; absorption is impaired by food
● Excreted by the kidneys; dose

A

BENZATHINE & PROCAINE PENICILIN G

24
Q

PKINETICS:

● Low bioavailability; absorption is impaired by food
● Excreted by the kidneys; dose adjustment may be required

A

PENICILIN V

25
Q

ROA of Pen G

A

IM/IV

26
Q

Roa of BENZATHINE & PROCAINE PENICILIN G

A

IM

27
Q

ROA of PENICILIN V

A

PO

28
Q

MOA of PENICILLIN G, BENZATHINE & PROCAINE PENICILIN G, PENICILIN V

A
  1. Bactericidal
  2. Prevents bacterial cell wall synthesis by binding to and inhibiting cell wall transpeptidases
  3. Inhibition of transpeptidase enzyme that act to cross-link linear peptidoglycan chains
  4. Activation of autolytic enzymes that cause lesions in the bacterial cell wall

PCOL - 3S (1 decks)

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