Penicilins Flashcards
Tipos y vías
Penicilina G (IM y IV)
Penicilina VK ( oral)
Probenecid
Boots PCN levels
Efectos adversos agudo
En menos de 1 hora Type 1- IgE mediated Histamine release Itching Urticaria Anafilaxis Broncoespasmo
Efecto adverso no inmediato
Días o semanas
Type IV (t-cell mediated)
Absence of fever, wheezing, joint pain.
Maculopapules
Steven Jhonson Syndrome
Toxic Epydermal Necrosis
3- Nefritis intersticial
Fever
Oliguria
WBC cast in urine (sterile pyuria)
4- Hemolytic Anemia
PCN binds to surface RBCs and antibodies began to bound to RBC. Direct Coombs test: positive
Type 2 hypersensitivity
5- Serum sickness
Days/ weeks after exposure
Type III hypersensitive reaction
Urticaria, fever, arthritis, lymphadenopathy.
Maculopapular rash
Viral infection
EBV pharyngitis
Amoxicillin given for pharyngitis
Skin reactions
1. Stevens- Johnson Syndrome Fever Necrosis Vesicles Blisters
- Toxic Epidermal Necrolysis
Severa forma de SJS
Ten: 25-35%
Reacciones según tipo
Type 1
Acute, IgE, Anaphylaxis
Type 2
Hemolysis
IgG
Type 3 Serum sickness IgG Fever Urticaria Arthritis
Type 4
T cells
Skin
Nephritis
Frequents association with Pseudomembranous Colitis
Clindamycin
Fluorquinolones
Cephalosporins
Penicillins
Why Jarisch Herxheimer Reaction..
Bacterial cell death—> immune response.
Jarich- Herxheimer Reaction
Febrile syndrome Fever Chills Flushing Hyperventilation 2 hours after therapy
Extended Spectrum Beta Lactamase atb
Plasmid- mediated bacterial enzymes
Le da resistencia a most neta lactamos atbs.
Bacteria that has ESBL
E. Coli Salmonella Pseudomonas Enterobacter Shigella Serraría Klebsiella
Drug of choose for ESBL
Carbapenems
