Pemphigus

Question 1

what is the epidemiology of pemphigus ? is it more common in men or women?

Answer 1

pemphigus vulgaris and pemphigus foliaceus in men and women is approximately equal.

Question 2

age of onset?

Answer 2

The mean age of onset of disease is 50 to 60 years, although the range is broad and disease arising in the elderly and in children has been described

Question 3

what is the incidence of Pemphigus? give examples of countries that have higher incidence of pemphigus?

Answer 3

limited data are available regarding the indence of pemphigus, in general, it ranges from 0.76 to 5 new cases per million per year,

with a higher incidence observed in the Middle East, Southeast Europe, and India.

Question 4

what is the incidence of pemphigus among Ashkenazi jews?

Answer 4

16 to 32 cases per million per year among ashkenazi jews?

Question 5

Generally what is the most widespread type of pemphigus ? are there any exceptions?

Answer 5

Vulgaris is the most widespread subtype.

with exception to Finland, Tunisia, and Brazil - foliaceus is more common there

Question 6

what the hell if FOGO SELVAGEM?

Answer 6

A clinically, histologically, and immuno pathologically similar to patients with sporadic pemphigus foliaceus.

However, fogo selvagem occurs in an endemic fashion in certain regions of Brazil and is thought to be caused by an environmental factor(s).

Question 7

how is fogo selvagem different from foliaceus ?

Answer 7

sporadic pemphigus foliaceus: is a disease of mostly middle-aged and older patients

fogo selvagem: affects young adults and children of either sex or any race who are exposed to the local ecology in rural areas, and the incidence gradually decreases as the area is developed.

Question 8

could you please explain a possible enviromental factor affecting \ involved in the mechanism of FOGO SELVAGEM?

Answer 8

The majority of patients live close to rivers and within the 10–15 km flying range of black flies (Simulium spp.), which may be the vector that precipitates the disease.

There is also a high frequency of hematophagous insects (bedbugs and kissing bugs) in the homes of patients with fogo selvagem. Of note, a salivary protein from the sand fly Lutzomyia longipalpis was shown to induce cross-reactive antibodies to Dsg1/