PEDs/NICU midterm Flashcards
Fertilization
union of the sperm cell and the mature ovum, occurs in the outer third of the fallopian tube
First stage
period from conception to the completion of implantation or about 12-14 days
- Results in two identical cells
- Rapid cell division
Ovum
developing organism name
Second stage
occurs from the end of the ovum stage to the time it measures roughly 3 cm from head to rump or around 54-56 days
- Called an embryo
- Tissues, organs, and organ systems differentiate
Blastodern
some of the cells go father toward one end forming
Third stage
what will remain until the end of pregnancy (210-214 days)
- Continued growth of organ systems
Fetus
organism is called this in the third stage
Neonate
used from delivery through the first month of life
Infant
used for the period from 1 month to 1 year of life
Child
identifies the patient above 1 year of age
Placenta
during the 40 weeks of gestational development, the placenta acts as the organ of respiration for the fetus
- Fetus receives nutrients and oxygen and rids itself of CO2 and other waste
- At term, occupies about ⅓ of the uterine surface, and weighs around 1 pound or 15-20% of fetal weight at term
- Blood coming from the fetus follows the two umbilical arteries to the placenta at which they branch into smaller and smaller vessels
Umbilical cord
lifeline between mother and fetus
- Consist of 3 vessels
Amnion
sac surrounding the embryo that contains the amniotic fluid
- Aries from the trophoblast around the 7th gestational day
Amniotic fluid
fluid that fills newly developed sac
- At term about 1 liter
- Constantly absorbed and replenished
- Allows fetal movement and provides protection
- Aids in thermoregulation
Embryonal stage
first 7 weeks gestation
- Development of anatomical structures of various organ systems
- Lungs begin to develop at 24 days
- Endoderm forms GI tract and CNS in 21 days
- Pharynx develops at 21 days
- Small buds that became right and left main stem bronchi develop at 28 days
- Lobar bronchi forming around day 31
Pseudoglandular stage
7-16 weeks gestation
- Further development of respiratory structures
- Differentiation of nasal cavity, oropharynx, nasopharynx
- Vocal cords develop at week 8
- Lungs continue to develop and begin to look like glands
- Goblet cells develop during 13th gestational week
Canclicular stage
weeks 17-26
- Terminal and respiratory bronchioles multiply
- Lungs become vascularized
- Alveoli begin to develop
- Smooth muscles develop around conducting airways to participate in gas exchange through the thinning air-blood barrier
Saccular stage
26 to between 34-36 weeks
- Baby 24-26 weeks, lungs completely form
- Continued development of the alveoli
Alveolar stage
true alveoli are present between 32-34 weeks
- Number of alveoli will increase until around age 8
Asphyxia
combination of hypoxia, hypercapnia, and acidosis
Fetal asphyxia
can be diagnosed by the use of scalp blood pH determination → 7.2-7.24 pH
- Most dangerous cause of fetal bradycardia (less than 100bpm) is asphyxia
- Oxygen administration to the mother may help reduce the severity of asphyxia to the fetus
- Bradycardia can be seen during second stage of labor
- FHR monitor can detect asphyxia
Tocolytics
Process of stopping labor
- Can be achieved pharmacological and nonpharmacological
- indicated when stage I labor begins prior to 37 weeks gestation and when placenta previa is present
Beta sympathomimetics
= relax smooth muscle contractions
Beta sympathomimetics that stop labor:
- Terbutaline sulfate
- Ritodrine
APGAR
developed as an objective way to evaluate the condition of a neonate
- First score is assessed at 1 minute
- Second score at 5 minutes and every 5 minutes after that up to 20 minutes
- 5 minute APGAR score is a predictive of future impairment with a low score of being associated with a high risk of long-term damage
APGAR 5 areas
- respiratory effort
- heart rate
- muscle tone
- reflex irritability
- color
Causes of increased WOB
- Increase in airway resistance
- Hypoglycemia
- Small diameter of nasal passage → can decrease caliber
Bacterial infection
Often caused by organisms found in the material intestinal and genital tracts
- Can be caused by also poor aseptic technique in the nursery or with equipment
Chorioamnionitis
inflammatory response in amniotic fluid which leads to outpouring leukocytes into the fluid from inflamed amniotic tissues
- mom and baby are malodorous
Streptococcus agalactiae or group B strep (GBS)
serious illness and even death in neonates
- GBS is a normal flora of both intestinal and female genital tract (25% females are colonized)
- Strep A, B, C and Listeria have strong evidence of abortion, premature birth, congenital disease, neonatal disease
Quiet examination
= observe
- Color
- Languo
- Activity
- Overall look
- Respirations/retractions → tachypnea respiratory rate above 160 bpm; bradycardia respiratory rate is below 100bpm
- Chest movements should be symmetrical
- Can see grunting and nasal flaring if baby is in distress
Acrocyanosis
baby’s body is pink but feet and hands are still blue in the first 24 hours following birth
Hand on examination
= start at the head and work down to the extremities
- Inspect head for cuts and bruises
- Inspect mouth to see any clefts or hindered breathing
- Examine ears to determine gestational age assessment scale
- Neck should be examined for presence of cyst or tumors
- Normal heart rate is between 120-160bpm
- Inability to maintain body temperature
- Reduced vigor
- Limp appearance
Neurological examination
= dependent on the degree of intrauterine development toward maturation
- Crying
- Response to touch
- movements
- Muscular tone
Thermoregulation
- Large skin surface area is prone to heat loss
- 80% of body weight is water
- Makes overhydration and dehydration difficult to manage
Thermoregulation techniques
- Placing baby in the warmer
- Placing baby on a warm blanket, warm mattress, warm towels
- Minimizing cold objects to the baby’s body
Cold stress
= hypothermia; is any lowering of the thermoneutral temperature
- Baby should be kept 97.9-99.5 (37 celsius)
**A COLD NEONATE WILL NOT RESPOND TO RESUSCITATIVE EFFORTS
Cold stress consequence
Peripheral vasoconstriction → shunt of blood away from the skin → anaerobic metabolism and metabolic acidosis
Increased metabolism of brown fat → glucose levels begin to fall → hypoglycemia
ROP
Formerly called retrolental fibroplasia (RLF) means the formation of scar behind the lens, which is the culmination of the disease (retinal vessels constrict) → necrosis of the vessels
- Affect infants born before 31 weeks gestation that weigh 1250 grams or less
Etiology ROP
- Supplemental oxygen
- Retinovascular immaturity
- Circulatory instability
- Respiratory instability
Treatment of ROP
Cryotherapy= introduces a probe that has been cooled to -20 celsius with nitrous oxide behind the eye and freezing the avascular portion of the retina, further abnormal vessel proliferation
Laser therapy= argon or diode lasers are used to photocoagulation the avascular portion of the peripheral retina
Vitrectomy and lensectomy are being investigated
Necrotizing enterocolitis (NEC)
= Idiopathic disorder characterized by ischemia and necrosis of the intestine in premature baby
factors causing NEC
prematurity, asphyxia, formula feeding
Mildest form of NEC
abdominal distention
Severe form of NEC
perforation of the intestine leading to sepsis and then death
Etiology of NEC
- Mucosal wall injury= ischemia/decreased blood flow to gut
- Bacterial invasion into the damaged intestinal wall
- Formula in the intestine= seen in 95% of infants with NEC
Treatment of NEC
= avoidance of factors that lead to its presence
- Good hand washing
- Oral feeding stopped → nasogastric suctioning on empty stomach
- Feeding through IV (hyperalimentation)
- Fio2 increased to raise arterial PaO2 levels and aid in mucosal regeneration
Pneumothorax
= develops when the extra alveolar air ruptures to the external surface of the lung and into the pleural space