Peds Anesthesia and Perioperative Considerations Flashcards
Pre-Term, Neonate, Infant and Child (days-years)
Pre-Term = prior to 37 weeks gestation
Neonate = 1-28 days
Infant = 28 days - 1 year
Child = > 1 year
Most significant part of transition occurs
within…….
first 24-72 hours after birth
4 Adaptive Changes
Establish FRC
Convert Circulation
Recover from birth asphyxia
Maintain core temperature
Where does fetal gas exchange occur?
PLACENTA
Fetal Hgb shifts oxyhemoglobin dissociation curve to the …..
LEFT!
-Increased O2 loading in the lungs/placenta, decreased O2 unloading at tissues]
O2 transport is accomplished by ______which totals _______.
fetal Hgb
70-90%
Hgb. full term neonate
18-20g/dl
Hgb does not go below …….
10!
0-30 days
4 Weeks fetal lung
primitive lung buds develop from foregut
Branching of bronchial tree complete to 28 divisions, no further formation of cartilaginous airways
16 weeks
primitive alveoli (saccules) and type II cells present; surfactant detectable; survival possible with artificial ventilation
24 weeks
capillary network surrounds saccules; unsupported survival
28-30 Weeks
true alveoli present, roughly 20 million at birth
36-40 Weeks
PaO2 rises as R to L mechanical shunts close
Birth-3 months
“Guppy Breathing in Utero” starts when?
From 30 weeks gestation, present 30% of the time at a rate of 60 breaths/min.
What are responsible for the decrease in neonatal PVR?
Changes in PO2, PCO2, and pH
-Increase in PO2, Decrease in CO2, Decrease in Pulmonary Vascular Resistance
The primary event of the respiratory system transition is ________.
INITIATION OF VENTILATION!
Infant must generate _____ negative pressure,
_____ cm H2O, to inflate the lungs
high
-70 cm H20
Established to act as a buffer against cyclical alterations in PO2 and PCO2 between breaths
FRC of approx. 25-30ml/kg
Why are neonate and infant lungs prone to collapse?
-Weak elastic recoil
-Weak intercostal muscles
-Intra-thoracic airways collapse during exhalation
What can help maintain FRC/lung inflation in the neonate during anesthesia?
PEEP of 5cm H2O
Infants terminate the expiratory phase of breathing before reaching their true FRC which results in ________.
intrinsic PEEP and a higher FRC.
Initial hyperapneic response is abolished by ______ and ______.
hypothermia and low levels of anesthetic gases
What causes profound bradycardia in babies?
HYPOXIA!
Contributing factors for apnea in infancy
-Increased O2 consumption 6ml/kg
-Decreased FRC (non-functional residual capacity)
-Increased closing volume
Why do intra and extra cardiac shunts exist?
to minimize blood flow to the lungs while maximizing flow/O2 delivery to organ systems