Peds Flashcards
Look bypasses lungs
Blood entering RV & PA bypasses lungs via ductus arteriosis
Pulmonary circulation is passed by
Placental blood passes thru Foramen ovale to LA
What happens to PVR & SVR in fetus
PVR is high & SVR is low
Birth changes to PBF, PVR, SVR,
PBF up, PVR down, PV return up
Umbilical clamping what happens
Inc SVR & BP - immediate
Activates Baroreceptors, inc LAP/MAP, dec PAP
What happens to FO at birth
Inc venous return to LA - FO closes (days to months)
Why ductus arteriosus constricts
Dec prostaglandins
Inc in blood O2 concentration
DA closes - pulmonary blood flow & O2 uptake inc
What can u do to keep DA open
Prostaglandin gtts,
avoid high oxygen
PNS vs SNS in neonate
PNS fully developed, while SNS is not till 4-6 months
What are kids under 4 month prone to
Bradycardia, causes drop in CO
What are some causes of bradycardia
Vagal stimulation
Hypoxia
Anasthetic overdose
Rx for bradycardia in infants
Robinual 10-20 mcq/kg or atropine, same dose
What is considered the hallmark of IV fluid depletion
Hypotension without tachycardia
Adequate urine output for peds
1ml/kg/hr
Minimal number of cases will have Foley catheter
Neonates and infants respiratory anatomy
Lg head & tongue Long, stiff epiglottis Funnel shape trachea Short neck Nose breathers till 4-6 months cricoid cartilage is the narrowest point till 5 years old
What does funnel trachea predisposes infants to
Post extubation stridor from ETT
True or false
Symmetrical bifurcation of R & L mainstaim bronchus can result in either R or L endobranchial intubation
True
Listen to both sides
Subglottic edema of 1 mm effects
Peds:
Area reduced by 75%
Airway resistance increased by x16
Adults:
Area reduced by 44%
Airway resistance increased by x3
What is Hg level for newborn & 3 months old
Newborn 17-19
3 months 9-10
When does physiologic anemia happens?
3 months
Fetal Hg differences
- Has a short life span
- Higher O2 affinity P50=19, therefore has higher O2 affinity & December release of O2 to tissue
- Tissue oxygenation improves with age
What are neonates and newborns predispose to ( resp system)…
Atelectasis & hypoxia
Why atelactisis & hypoxemia
- Dec lung compliance & hypoxemia
- These result in dec FRC
- High O2 consumption
Retinopathy r/t
High concentration of O2
- Newborns <90% jeopardizes organ/tissue oxygenation
What is the tidal volume
7-10 ml/kg usually PC vent, close to 10
What are type I muscles?
Slow twitch, high oxidative, sustained muscles ( Richard Simmons)
Type II ventilatory muscles
Fast twitch, low oxidative, immediate but short activity (Arnold Schwartzeneger)
Diaphragm Type 1 in Premature, Newborn Infant
Primary muscle of ventilation
Premature : 10% of Type I
Newborn : 25% of type I
Infant. : 55%- matures at 8 months
Intercostal muscles
Premature
Newborn
Infant
Premature: 20% type I
Newborn: 46%
Mature at 2 months of age
When does diaphragm & intercostal muscle mature
Diaphragm 8 months
Intercostal is 2 months
Neonates have less type I < type II
Neonates are most susceptible to fatigue with…
Airway obstruction
Pneumonia
Secretions
Who has less efficient ventilation
Neonates have less efficient ventilation & use up lots of energy
When do fontanelles close
Anterior 18 months to 2 years
Posterior 6 months
What is the largest factor in cause of decreased CPP
Hypotension
What age cerebral blood flow reaches its max
5 years old
Cerebral blood flow
Preemie
Infant
Adult
Preemie: 30-40 ml/100gm/min
Infant/child: 65-80
Adult: 50
What are factors that predispose to intraventricular hemorrhage
Hypoxia Hypercarbia Hypernatremia Fluctuation in arterial/venous pressure & CBF NaHCO3
Preterm cerebral vessels are subject to…
HTN, are fragile
Are liver enzymes present at birth and what and when fully functional
Yes, CYP 450, fully functional @1 month
Physiologic jaundice
Bilirubin levels peak @ 3-5 days of life
How is liver during gestation
Partially nonfunctional d/t shunted ductal flow
Obligate Na losers
Neonates continue to excrete Na even in deficit
What should fluids always contain in neonates
Na,
Low Na can cause seizures
GFR is low at birth
1 month
9 months
12 months
1 month: 70% mature
9 months : 90% mature
1 year: Almost completely mature
What cause GEReflux in infants
Incompetent lower esophageal sphincter
High risk for aspiration
Why infants/neonates/sm kids are at high risk for hypothermia
Large SA to body surface
Lack of SQ tissue
Large head
Steps of thermogenesis
Cold to hypothalamus —SNS activation/release of NE—NE stimulates release of lipase from brown fat which splits triglycerides into glycerol & FFA—-FFA oxidized —ATP — heat
Where is brown fat
Inner scapular space Around lg brown vessels Neck Behind sternum Around kidneys/adrenals
Effects of hypothermia
Inc O2 consumption Metabolic acidosis Inc PVR - intracardiac shunting across PFO or PDA Dec BP - depletion of NE stores Dec BS - depletion of glycogen stores