Pedigree Analysis

Question 1

Who do punnet squares work for?

Answer 1

Organisms with large numbers of offspring and undergo controlled mating

Question 2

What are the goals of pedigree analysis?

Answer 2

• Determine mode of inheritance (e.g. dominant)

- Determine probabilty of an affected offspring for a given cross

Question 3

What are ‘outsiders’ in pedigree?

Answer 3

-People whose parents are unknown (assumptions need to be made)

Question 4

What are the assumptions for outsiders

Answer 4

• Dominant: affected outsiders are heterozygotes

- Recessive pedigrees (unaffected) are homozygotes

Question 5

What is a consanguineous mating?

Answer 5

Mating of 2 related people (closest = 2nd cousins)

-Often involved with autosomal recessive diseases

Question 6

What are 3 examples of recessively inherited diseases?

Answer 6

1. CF
2. Tay-Sachs
3. Sickle Cell

Question 7

What are multifactorial disorders?

Answer 7

• Alleles from a single genetic locus
• Genetic + environment
  e. g. diabetes

Question 8

Where to fathers pass their sex-linked alleles too?

Answer 8

• All of their daughters

- None of their sons

Question 9

What is ‘hemizygous’

Answer 9

A sex-linked trait on the x chromosome of a male

Question 10

What are 3 examples of sex-linked disorders?

Answer 10

• Duchenne muscular dystrophy
• Haemophilia
• Red-green colour blindness

Question 11

What are the assumptions for recessive sex-linked pedigrees in outsiders?

Answer 11

Normal outsiders are assumed to be homozygous