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Pediatrics II > Pediatrics: Leukemia/Lymphoma > Flashcards

Pediatrics: Leukemia/Lymphoma Flashcards

1
Q

what is the most common childhood cancer?

A

ALL

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2
Q

A patient presents with:

Anemia Sxs
Petechiae, purpura
Bone Pain
Hepatosplenomegaly
LAD

What is this concerning for?

A

ALL

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3
Q

the following labs are indicative of:

CBC:
-pancytopenia

Peripheral smear:
-lymphoblasts

Bone Marrow Biopsy:
-lymphoblasts

A

ALL

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4
Q

This leukemia is treated with:

Multi-drug chemo x 2-3 yrs
HSCT

A

ALL

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5
Q

A patient with ALL is presenting with:

Hyperkalemia
Hyperuricemia
Hyperphostphatemia

This is concerning for?

A

Tumor Lysis Syndrome

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6
Q

A patient presents with:

Anemia S/S
HA
AMS
CN Palsy

This is concerning for what?

A

AML

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7
Q

Aeur rods on peripheral smear indicate…

A

AML

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8
Q

20% myeloblasts on bone marrow biopsy indicates…

A

AML

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9
Q

Profound Leukocytosis (> 100k) is emergent in what condition?

A

AML

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10
Q

What 2 therapies treat AML?

A

chemo

HCT

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11
Q

A patient presents with:

Massive Splenomegaly
Hepatomegaly
Fever
Night Sweats
Fatigue

This is concerning for

A

Late stage CML

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12
Q

A patient presents with the following lab findings:

CBC:

  • Anemia
  • thrombocytosis
  • Profound Leukocytosis

Peripheral Smear:

  • Myeloid cells in all stages of development
  • 20% blasts
A

CML

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13
Q

What test is diagnostic for CML?

A

Philadelphia Chromosome

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14
Q

What does the treatment regimen for CML look like?

A

Control with Tyrosine Kinase Inhibitor

Cure with HCT

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15
Q

The following presentation is concerning for what?

Hx of EBV

Painless Cervical/Supraclavicular LAD

B Sxs

Mediastinal Mass

A

Hodgkin lymphoma

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16
Q

What should you expect to see on biopsy in hodgkin lymphoma?

A

Reed Sternberg Cells

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17
Q

How is Hodgkin Lymphoma Treated?

A

Chemo/Radiation

Autologous HCT

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18
Q

A patient presents with:

Rapid Onset of sxs
Non-tender, enlarging LAD
B-sxs
Hepatosplenomegaly

This is concerning for?

A

non-Hodgkin Lymphoma

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19
Q

What is an ED precaution for non-hodgkin lymphoma?

A

tumor lysis syndrome

20
Q

What is the treatment regimen for non-hodgkin lymphoma?

A

chemo

Autologous or allogenic HCT if relapse

21
Q

A patient with the following presentation is concerning for…

Increased head circumference
AM Headache
vomiting
Papilledema

A

Brain tumor

22
Q

What is the preferred imaging modality for brain tumors, but what is often used instead with pediatric patients becasue it is faster?

A

MRI preferred

CT faster

23
Q

A brain tumor is definitively diagnosed with…

A

tissue biopsy

24
Q

Astrocytoma and ependymoma are what type of tumor?

A

glial

25
Q

What is the tx of choice for brain tumor?

A

surgical resection

26
Q

A patient presents with:

Firm, Fixed abdominal mass that crosses midline

Fever
Weight Loss
Irritibility

A

Neuroblastoma

27
Q

What is the MC non-CNS solid neoplasm?

A

neuroblastoma

28
Q

A patient with elevated urinary catecholamines should be concerning for…

A

neuroblastoma

29
Q

What is the treatment of choice for neuroblastoma?

A

surgical resection and chemo

30
Q

A patient presents with:

Asymptomatic abdominal mass that doesn’t cross midline

Fever

Hematuria

HTN

this presentation is concerning for…

A

nephroblastoma (Wilm’s Tumor)

31
Q

What imaging modalities can be helpful for nephroblastoma (Wilm’s Tumor)?

A

Abd. US
Abd. CT
Chest CT

32
Q

What is definitively diagnostic for nephroblastoma?

A

biopsy/excision

33
Q

What is the tx of choice for nephroblastoma (Wilm’s Tumor)?

A

Surgical Exploration

Chemo/Radiation

34
Q

What is the most common bone tumor, especially common in boys 13-16 yo?

A

Ostoesarcoma

35
Q

A patient presents with:

Bone pain
Soft tissue mass
Antalgic Gait

A

Osteosarcoma

36
Q

Where is the common site of osteosarcoma?

A

metaphysis of long bones

37
Q

An x-ray shows the following:

Irregular margins

Trabecular pattern.

This should be concerning for…

A

osteosarcoma

38
Q

A patient with the following presentation is concerning for what?

Pain in long-bones or pelvis
Worsening, local pain
Pain worse at night
Fatigue
Fever
Weight Loss
A

Ewing Sarcoma

39
Q

What confirms ewing sarcoma?

A

biopsy

40
Q

A patient < 5 yo presents with:

Leukocoria
Inflamed eye

A

Retinoblastoma

41
Q

How is retinoblastoma diagnosed?

A

ophthalmalic exam under anesthesia

42
Q

Can you do biopsy in suspected retinoblastoma

A

no

43
Q

What tx is used for retinoblastoma?

A

external beam radiation

44
Q

A patient < 6yo with the following presentation should be concerning for…

Painless enlarging mass

proptosis/exopthalmos

hematuria
Urinary obstruction
pelvic mass

A

Rhabdomyosarcoma

45
Q

A patient presents with:

Enlarging Abdomen
Elevated AFP

This is concerning for…

A

Hepatic Tumor

46
Q

What is the essential treatment for surviving hepatic tumors?

A

complete resection of tumor

Pediatrics II (5 decks)

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