Pediatrics Flashcards

Review pediatric questions encountered on UWorld and master them!

1
Q

Red spots with bluish specks over the buccal mucosa

A

Koplik’s spots - Measles (Paramyxovirus infection)

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2
Q

What type of virus causes measles?

A

Paramyxovirus

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3
Q

Chronology of measles

A
  1. Exposure to virus, respiratory droplets
  2. Prodrome after 10 days (cough, coryza, conjunctivitis)
  3. Koplik’s spots appear 48 hours before skin rash
  4. Erythematous maculopapular rash starts on face -> trunk and extremities
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4
Q

Which virus causes roseola?

A

HSV-6

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5
Q

Complications of measles?

A

Early: PNA, vitamin A deficiency, bronchiectasis
Late: Immunosuppression and subacute sclerosing pancencephalitis

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6
Q

Causes erythema infectiosum

A

Parvovirus

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7
Q

Hypotonia, hepatosplenomegaly, cervical lymphadenopathy, protruding abdomen, ‘cherry red spot’ on retinal examination. Regression of developmental milestones

A

Niemann-Pick’s disease

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8
Q

What is Niemann-pick’s disease?

Pathophysiology of this disease?

A

Sphingolipidosis due to deficiency of SPHINGOMYELINASE.

Sphingomyelin (ceramide phosphorylcholine) accumulates in the reticuloendothelial cells of liver, spleen, bone marrow, brain.

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9
Q

Deficiency in Tay-Sach’s

A

HEXOSAMINIDASE A

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10
Q
Hyperacusis
Mental retardation
Seizures
Cherry red macula
NO hepatosplenomegaly
NO cervical lymphadenopathy
A

Tay-Sach’s disease

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11
Q

Deficiency in Gaucher’s disease?

A

GLUCOCEREBROSIDASE - a sphingolipidosis

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12
Q
Hepatosplenomegaly
Anemia
Leucopoenia
Thrombocytopenia
NO cherry red macula
A

Gaucher’s disease - a spingolipidosis due to deficiency in glucocerebrosidase

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13
Q

Hyperacusis
Irritability
Seizures

A

Krabbe’s disease - GALACTOcerebrosidase deficiency

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14
Q

Deficiency in Krabbe’s disease

A

GALACTOcerebrosidase deficiency

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15
Q

GALACTOcerebrosidase deficiency

A

Krabbe’s disease

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16
Q

deficiency in glucocerebrosidase

A

Gaucher’s disease

17
Q

Hexosaminidase A deficiency

A

Tay-Sach’s

18
Q

Sphingomyelinase deficiency

A

Niemann-pick’s

19
Q

Coarse facial features
Hydrocephalus
Umbilical hernia

A

Mucopolysaccharidoses

20
Q

7 year old boy with bleeding gums, fatigability, punding sensation in ears, 5th percentile growth, bent thumbs, hypopigmentation. Hgb 7.8g/dL, MCV 112, platelets 40,000/mm3

A

FANCONI ANEMIA - AR disorder causes congenital marrow failure, poor growth, morphologic abnormalities, macrocytic anemia

21
Q

Clinical manifestations of fanconi anemia?

A

BONE MARROW - aplastic anemia and progressive bone marrow failure

APPEARANCE - short stature, microcephaly, abnormal thumbs, hypogonadism

SKIN - Hypopigmented/hyperpigmented areas, cafe au lait spots, large freckles

EYES/EARS - strabismus, low-set ears, middle ear abnormalities, hemorrhage, incomplete development, chronic infections, deafness

22
Q

Industrial chemical known to cause aplastic anemia?

A

Benzene

23
Q

Approximately 5-15% of patients with thymic tumors have this?

A

Pure red cell aplasia, m/c in older women

24
Q

The leading cause of cobalamin deficiency?

A

Autoimmune pernicious anemia due to anti-intrinsic factor autoantibodies.

25
Q

Sore throat, hyperemic and edematous oropharyngeal mucous membranes, cheilitis, stomatitis, glossitis, normocytic-normochromic anemia, seborrheic dermatitis, photophobia

A

Riboflavin deficiency (Vitamin B2)

26
Q

What is pellagra?

A

Niacin deficiency (Vitamin B3)

symmetric reddish rash in skin, red tongue, nonspecific symptoms - diarrhea, vomiting, insomnia, encehphalopathy

27
Q

Vascular ring anomaly

How would you differentiate presentation of this disease from esophageal atresia?

A

trachea and esohagus are completely encircled by the aortic arch and its branches. Noisy breathing noted in first few weeks of life.

Esophageal symptoms such as choking, vomiting or dysphagia occur in OLDER infants and children (not infants)

28
Q

Normal Hg for male

A

13.5-17.5 g/dL

29
Q

Peripheral smear shows schistocytes and giant platelets

A

Microangiopathic hemolytic anemia (Hemolytic uremic syndrome)

30
Q

Labs on ITP

A

ISOLATED thrombocytopenia, Morphology of red cells is normal!

31
Q

Child recently recovered from diarrheal illness presents with acute renal failure, microangiopathic hemolytic anemia, fever, thrombocytopenia + Schistocytes

A

HEMOLYTIC UREMIC SYNDROME

32
Q

Classic triad for HUS?

A

Microangiopathic Hemolytic Anemia
Acute Renal Failure
Thrombocytopenia

33
Q

Pathophysiology of HUS?

A

Related to Escherichia coli 0157:H7 infection (STEC)

- Proinflammatory factors (IL-8, TNFa)
- Prothombotic Changes
    - Fibrin deposited in renal microvasculature
- Verocytotoxin induces endothelial injury
    - Red Blood Cell destruction
    - Platelet destruction, consumption, sequestration
    - Platelet thrombus formation
34
Q

Normal LDH

A

45-90 U/L

May be elevated ~900 in HUS

35
Q

Normal ESR?

A

Male 0-15 mm/h

Female 0-20 mm/h

36
Q

M/C cause of hip pain in children?

Most common age groups?

A

TRANSIENT SYNOVIITS - typically occuring in boys age 3-10. Follows viral infection or mild trauma.

37
Q

Tx for transient synovitis?

A

Rest and ibuprofen

B/L hip x-rays to assess for Legg-Calve-Perthes disease

38
Q

Features of septic arthitis of the hip?

A
Fever > 101F
Inability to bear weight
WBC > 12k/mm3
ESR >40 mm/h
CRP > 2mg/dL