Pediatrics 2 Flashcards
GI, GU, Cardio, ENT, Resp, and DERM
White plaques inside mouth on mucosal surface that is a common oropharyngeal infx
Tx
Thrush
Oral Topical Nsytatin and antifungal fluconazole PO
Tx - of mother’s nipples and bottle nipples boiled 20min Inhaler steroids–> cause
pain, breathing difficulties, poor growth from poor feeding, iron deficiency anemia,
retrograde movement of gastric contents upwards. increased risk of asthma, esophageal stricture, barretts
Gastro Esophageal Reflex Disease
Dx and of GERD
24 hour esophageal pH probe “Gold standard”
Upper GI barium fluoroscopy (R/O Anatomy causes)
Upper endoscopy EGD (Evaluate known GERD)
Tx GERD
Thicken formula w tsp of rice cereal
smaller more frequent feedings
Upright position
casein formula- no eating prior to bed
Ranitidine, Metoclopromide, sx,
Retrosternal and epigastric pain. caused by GERD, medication, caustic chemicals, candida.
dx endoscopy-
Esophagitis
Tx Esophagitis
NPO and Iv fluids
Viscous lidocaine PPIs
Sucralfate Metoclopramide
FTT, vomiting, vague abd. pain, dysphagia, food impaction. DX - w biopsy= eosinophils > 15
Barium swallow- stricture or food impaction. Patch testing.
Eosinophilic Esophagitis
Tx- High dose PPI
Daily pain. Not assoc. w meals or relieved by defecation. Assoc. w anxiety, school stress,
worse in am. prevents from attending school. No evidence to explain s/s. 1/week for 2 mos.
Functional Abdominal Pain
Fluctuating stool pattern between constipation and diarrhea. Defecation relieves pain. School avoid 2ndary
Assoc w change in frequency and form of stool. 1/wk for 2 mos
Irritable Bowel Syndrome
Frequently watery stools with normal growth/weight gain. DT excessive intake of sweetened liquids
caloric intake is adequate. S/S lasts >4 weeks
Functional Diarrhea
Tx- Fiber, probiotics, CBT SSRI, dec. milk intake
<= 2 stools/week or passage of hard pellet like for at least 2 wks. Retentive posturing.
Constipation
Tx- Polyethylene Glycol Milk of magnesia, Mineral oil (Non-habit)
Regular voluntary or involuntary passage of feces into a place other than the toilet >4 YOA
Chronic constipation #1 cause. Assess for rectal fissures. KUB to confirm fecal size
Encopresis
TX- Encourage regular stooling. Inc fluid/fiber. Child must be pain free 1st then goal is to relief constipation
injury to small intestine mucosa from gluten. Wheat, Rye, barley, –> malabsorption and malnutrition
Assoc w DM1, Thyroiditis, **Turner syndrome and Trisomy 21 **
Celiac Disease
Dx of celiac Dz
Must be eating Gluten when testing. Serum IgA Antigliadin Ab Villous Atrophy- mucosal inflammation
Tx- Life long avoidance Gluten
Milk or soy protein induced colitis. Common cause of bloody stools in infants. less common in breast fed.
Abd. distention, gas, fussiness after feeds. loose, blood streak tools. No NVD or abd. pain
Dx- Eosinophils in feces and rectal mucosa biopsy
Allergic colitis
Tx - Casein hydrolysate Mom restricts Milk and soy
MC cause diarrhea in winter. vomiting 2-4 days, diarrhea 7-10 days. dehydration in children. vaccination–> less common
Associated ocean cruises.
Rotavirus
Norovirus (Calcivirus)
Fever, HA, Abd. pain, worsens over 48-72 hrs w nausea, decreased appetite or constipation.
Bowel perforation in adults, hematochezia or melena
chronic carriers are asymptomatic
Typhoid fever (Salmonella Typhi)
Transmitted via contact w infected animals. chieckens, iguanas, reptiles, turtles. Dairy, eggs and poultry
Nontyphoidal salmonella
Bloody diarrhea w high fever. blood and mucus foul smelling. Shiga toxin-Shigella
blood loss significant w EHEC, EIEC, Campylobacter, Yersinia
Dysentery
Watery non bloody or mucoid. Absent or low grade fever. Involves ileum. 4-5 stools a day last 4 days
V. Cholerae or ETEC Entero toxin E Coli
person-person contact and contaminated water/food
Poultry, raw milk, cheese. self limited.
Abx if high fever or grossly blood diarrhea, s/s over 1 week or immunocomp
Campylobacter Jejuni
Transmitted by pets and contaminated food especially chitterling (tripitas) mimics appendicitis or Crohn’s
Post infectious arthritis, rash, spondylopathy.
tx supportive care
Yersinia Enterolitica
Pseudomembranous colitis in hospitalized inpatient. Assoc. w abx use –> overgrowth of bacteria–> infl. bowel
Tx - DC ABx, Metronidazole or vancomycin
Clostridium Difficile
Endemic to US, day care centers. freshwater/well contaminated, infected feces–> ingested cyst
progressive anorexia, nausea, gaseousness, abd. distention.
E. Hystolitica/Giardia Lamblia
Cryptosporidium Parvum (Prolonged diarrhea Aids)
Tx for Acute Gastroenteritis
Shigella- Cipro
Salmonella- Cipro (Ampicillin immune comp)
E. Coli- Cipro-Z pack (Not 0157)
C. Difficile and Giardia (Metronidazole)
Fluid resuscitation for kids and neonates
20ml/kg
10ml/kg Neonates (Give over 20 min, Both)
Both X3 boluses max then admit
Maintenance fluid therapy (D5W if maintenance)
4ml/kg/hr for 1st 10kg
2ml/kg/hr for second 10kg
1ml/kg/hr for each kg> 20kg
1/2 over 8 hrs remainder over 16 hrs
autoimmune destruction of pancreatic islet cells (Beta cells) permanent insulin deficiency.
Polydipsia
polyuria
polyphagia
Diabetes Mellitus I
Dx of DMI or DM II
Requires two separate tests
Fasting glucose= >= 126 mg/dL
Random venous Plasma >= 200 mg/dL
Oral Glucose tolerance test >=200mg/dL 2 hr post 75G
HgB A1C >=6.5
Acute MC complications of Diabetes Mellitus, Tx
Hypoglycemia
glucagon or IV Glucose
Physiologic GH release –>early am hyperglycemia that persists throughout night.
Tx increase PM insulin dose
Dawn Phenomenon (Common)
Toolarge night time insulin dose leads to early am hypoglycemia–>rebound hyperglycemia on waking
Tx- Decrease PM insulin
Somogyi Phenomenon
Occurs when DM1 not detected/dx/poor compliance.
Metabolic acidosis w anion gap. severe dehydration
decreased tissue perfusion. incr. lactic acid prod. Kussmauls rep., NV, polyuria/dipsia, K+ depleted
fruity odor on breath. AMS
Diabetic Ketoacidosis
Dx and Tx
Serum Glucose 200-1,000, pH 7.3, Bicarb < 15
Tx- Fluids 1st, Insulin Iv- 0.1 U/kg/hr
Most serious complication of Diabetic Ketoacidosis
Cerebral Edema
Tx IV mannitol, ET/ventilate, subdural bolt
Peripheral resistance and compensatory hyperinsulinemia. pancreatic failure. obesity Afr. Amer.
Acanthosis Nigricans. Metabolic syndrome
DM II
Tx- Metformin 1st line
Group of dominantly inherited forms of mild diabetes
No insulin resistance.
Insufficient insulin secretory response to Glycemic stimulation. Tx sulfonylureas
Maturity-Onset Diabetes of youth (MODY)
Neonatal Renal disease Dx
UA/ Urine Cx (always w peds UA)
Ultrasound 1st Line
Voiding Cystourethrogram (VCUG)
Dx Modality for kidney structure and function
CT and MRI
Dx Modality observes reflux and evaluates urethra
repeated filling/emptying of bladder after radio dye
Voiding Cystourethrogram (VCUG)
Dx modality that evaluates kidney size, scars, and fx /excretion
Readionuclide studies
Neonate- Failure to thrive, feeding, problems feeding, fever.
1mo-2 yrs: Feeding problems, FTT, diarrhea, vomiting, unexplained fever. (All unexplained fevers)**
> 2 yrs: urgency, dysuria, frequency, abd./back pain
Urinary tract infection
UTI Dx
Pyuria> 50,000 older >100,000
Urine Luekocyte esterase and nitrate (70% sensiyive)
> 3-5 Epithelial cells = worry for validity of UA(Transurethral catheterization)
UTI Tx:
Positive Urine Cx and No ill appearing= PO Abx
Toxic dehydrated, no PO, 14 days parenteral Abx
No response w/I 2 days re-eval and prompt imaging
Investigation of UTI through imaging
Renal/Bladder US- All boys w UTI, girls <3 yoa,
3-7 yoa Girl >101.3
Abnormal US–> VCUG
retrograde urine flow from bladder up to the ureter or kidney. caused by congenital ureterovesical Jx incomp.
Cystitis or bladder obstruction–> intravesicular pressure.
Vesicoureteral Reflux (VUR)
Reflux into ureter, ,pelvis, and calyx w mild to moderate dilation or tortuosity of ureter pelvis
Grade III VUR
Moderate dilation /tortuosity of ureter /pelvis. complete obliteration of sharp angle of fornices
maintenance of papillary impression within calyx.
Grade IV VUR
Tx- Prophylactic Abx therapy
Dextranomer/hyaluronic acid copolymer
Sx
Gross dilation /tortuosity of ureter /pelvis w loss of papillary impressions in most calyces
Grade V VUR
Tx- Prophylactic Abx therapy
Dextranomer/hyaluronic acid copolymer
Sx
Reflux into ureter but does not extend to renal pelvis.
Reflux into ureter, pelvis, renal calyx but no dilation.
Grade I VUR
Grade II VUR (Both resolve w/o sx)
Tx- Dextranomer/hyaluronic acid copolymer
Persistent heavy proteinuria (Albuminuria). Hypoproteinemia, hypercholesterolemia, Edema
Reduced plasma oncotic pressure, GFR and renal flow remain normal. HLA types higher incidence.
MC pitting edema or ascites, HTN 25%, sudden dec. in Albumin, proteinuria x2 random urine,
Nephrotic Syndromes
Primary Nephrotic syndromes
Focal Glomerulosclerosis
Minimal Change
Membranoproliferative
Idiopathic membranous nephropathy
Absence of gross Hematuria*, MC form of its class. Responds well to steroids. (No renal Bx)
Renal insufficiency, HTN, hypocomplementemia
(Normal C3 Complement)
Minimal Change Nephrotic Syndrome
Less impressive proteinuria circulating factor affecting glomerular permeability found in some patients
Initially respond to steroids, but later build resistance
Primary Focal/Focal Segmental Glomerulosclerosis
Hypocomplementemia w signs of glomerular dz
High likelihood of kidney failure over time
Membranoproliferative Glomerulonephritis
MC in adolescents and children w systemic infections
HEP-B, Syphilis, malaria, toxoplasmosis, Gold Penicillamine
Idiopathic Membranous NS
Secondary nephrotic syndromes
SLE, Henoch-schonlein purpura, Wegener (Vasculitis)
Chronic infections (Hep-B/C, Malaria, HIV
Allergic reactions DM CHF Thrombosis
Nephrotic Syndrome Dx
Renal biopsy when Minimal Change NS not suspected
24 hr urine protein Low serum protein Albumin
Gross hematuria, proteinuria, edema, Oliguria, renal insufficiency
Glomerulonephritis
Glomerulonephritis types
Rapidly progressive Glomerulonephritis
Post-streptococcal Glomerulonephritis
Hereditary Nephritis (Alport Syndrome)
IgA Nephropathy (Berger’s)
X chromosome mutations in type IV collage–> abnormal glomerular basement membrane
Males: Renal failure and SNHL (Hearing)
Females: Microscopic hematuria (More benign course)
Hereditary Nephritis (Alport Syndrome)
MC chronic Glomerulonephritis. Microscopic/ recurrent Hematuria concurrent w URI. Inc risk for ESRD
Normal compliment levels. Renal Bx definitive
IgA Nephropathy (Berger’s Dz)
MC Acute Glomerulonephritis. Boys 2-12 yoa after pharyngitis (5-21 days post) Impetigo (4-6 wks post)
Abx still warranted , does not prevent. 95% recover completely. Antistreptolysin blood test
Post-Streptococcal Glomerulonephritis
Renal insufficiency progresses quickly and severely. Glomerular epithelial proliferation w crescents.
Early recognition crucial to prevent ESRD
rapidly Progressive Glomerulonephritis
Glomerulovascular injury caused by a toxic infection microangiopathic hemolytic anemia/Thrombocytopenia
Renal injury. Prodromal diarrhea illness. MC E. Coli 0157:H7 and shigella toxin. Schistocytes Micro slide
enterocolitis w bloody stool. HTN, Inc. Amylase/lipase
Hemolytic Uremic Syndrome (HUS)
Hemolytic Uremic Syndrome (HUS) Tx
IV repletion HTN Control (95% recover)
Renal insufficiency–> Dialysis
Transfusions Abx/Andiarrheals–> HUS
Gene mutations resulting in cystic dysfx kidneys. MC inherited kidney dz. Polycystin 1 or 2 defects.
Hepatic, pancreatic, splenic, ovarian cysts. Middle adulthood
Polycystic Kidney Dz Autosomal Dominant
Gene mutations resulting in cystic dysfx kidneys. Fibrocystin defects. Marked Bilateral enlargement.
Kidney failure early adulthood. Hepatic fibrosis. flank masses, interstitial fibrosis and tubular atrophy
Polycystic Kidney Dz Autosomal Recessive
Produces no symptoms because collecting system develops normally and ureters enter the bladder
7% have Turner’s syndrome
Horeshoe Kidney
Unilateral normal to reduced renal fx. assoc. w VUR, VACTERL, Turner’s. BILAT insuff. lung develop.
Assoc. w potter’s syndrome. Flat facies, Clubfoot, pulmonary hypoplasia. Common DM Af Amer
Bilat multicystic/ Dysplastic kidneys
Renal Agenesis
Sudden onset intense unilateral testicular pain. triggered by sudden movement/sports. adolescents
NV, bell clapper deformity. High riding testicle, absent cremasteric reflex (stroke and elevate teste), negative phren’s (inc. pain w lift)
Testicular torsion
Testicular torsion Dx & Tx
Dx- US Doppler absent blood flow
Immediate Urology consult: Detorsion w/I 6 hrs
MC in premature infants. Can lead to testicular cancer 5X and infertility. If not accomplished by age 1 yoa refer
Cryptorchidism (Orchyplexy 2 yoa)
Fluid collection in tunic vaginalis. Common in neonates
Communicating= w peritoneal space. Translluminates
small in am enlarges during the day (sx persists)
Non-communicating processus vaginalis obliterated (Resolve spontaneously) if persist 1 yoa refer
Hydrocele