pediatrics 1 Flashcards
what is considered as a neonate?
< 1 month
what is considered as a preterm baby?
< 36 weeks gestation
what is considered a term baby?
> /= 36 weeks gestation
what is considered an infant?
1 month to 1 year
what is considered a child?
1-11 years
what is considered an adolescent?
12-18 years
what is considered low birth weight?
1500 g to < 2500 g
what is considered a very low birth weight/
<1500 g
what are 3 unique things of pediatric pharmacy?
- difficulty in conducting research
- diverse patient population
- lack of adequate dosage forms
when should you not give aspirin to a patient?
< 20 years old unless prescribed by a doctor
what age should tetracyclines be avoided?
children less than or equal to 8
the use of medications outside its FDA approved labeled indication(s) include what 3 things?
- age range
- disease or illness it treats
- route of admin.
when is off label drug use legal and well accepted?
if based on appropriate clinical judgement
what are 2 limitations to off label drug use?
- liability
- denied insurance coverage
what act provided financial incentives for companies to voluntary study drugs in the pediatric population?
FDAMA
what act extended the patent exclusivity of FDAMA through 2007 and was reauthorized in 2007 and 2012 permanently?
Best pharmaceuticals for children act (BPCA)
what act requires studies on indications under review; minimum assessment is PK/PD and safety and requires phramaceutical companies to test in the pediatric population a new drug likely to be used in children?
Pediatric research equity act (PREA)
___ is more variable than anrticipated
PK
higher doses of what drug were required to control seizures in those younger than age 5?
gabapentin
what drug recommends higher doses in adolescents than were previously indicated, with the exception of girls aged 8-11 who may require lower doses because the drug can make them drowsy?
fluvoxamine
what adverse reaction of gabapentin was seen in children < 12?
aggression and hostility
what was experienced in children who were taking fluoxetine?
limited growth
how is the pulse measured in young babies?
listening to the heart, palpating peripheral pulse or observing the anterior fontanel
when is the circadian rhythm in the heart observed?
at 2 yrs