Pediatric Registry Review Flashcards
Curved Array Transducers
Crystals arranged in the shape of an arc. Provide a wide field of view in the near field.
Linear Array Transducers
Crystals arranged in a line. Rectangular shaped image. Evaluation of Neonatal spine, infant abdomens, bowel wall, brain, MSK, abdominal and superifical parts.
Phased Array Transducers
Crystals arranged in a line. Image produced is pie shaped or vector shaped. Possess a small footprint making them advantageous for intercostal scanning, echocardiography or chest. Also, head imaged.
Narrow bandwidths emit __ frequencies.
Few
Broad bandwidths emit __ frequencies.
Many; multi-hertz transducers have broad bandwidths, which allow the operator to change the frequency; harmonic imaging also results in broad bandwidths.
Frequency and Penetration are ___ proportional.
Inversely
Frequency and Spatial Resolution are __ proportional.
Directly
What is spatial resolution?
Capability of depicting structural detail (axial and lateral resolution)
Axial Resolution
display 2 closely spaced targets parallel to the sound beam as 2 distinct targets.
Dependent on the transducer’s spatial pulse length (SPL)
Spatial pulse length in ultrasound imaging describes the length of time that an ultrasound pulse occupies in space. Mathematically, it is the product of the number of cycles in a pulse and the wavelength. A shorter spatial pulse length results in higher axial resolution.
Lateral Resolution
ability of the transducer to display two targets perpendicular to the path of the sound beam as 2 distinct structures.
Improved with focusing and higher frequency transducers.
Propagation Speed of Soft Tissue
1540 m/s
Propagation Speed of Water
1480 m/s
Propagation Speed of Blood
1575 m/s
Propagation Speed of Bone
4080 m/s
Propagation speed is inversely proportional to:
density, elasticity and compressibility
Propagation speed is directly proportional to:
stiffness
Reflection
return of the sound beam back to the transducer; responsible for CREATING the image
Refraction
change of direction or bending of the sound wave as it passes from one tissue to another
only occurs if there is a change in velocity between 2 media and there is an oblique angle of incidence
Attenuation
weakening of the amplitude or intensity as it travels through a medium
Sources include absorption, reflection, scattering, refraction and interference
Dynamic range controls:
the number of gray shades represented in the display; the higher the dynamic range, the greater amounts of display and the lower the dynamic range, the less gray displayed (more contrasty)
Tissue Harmonic Imaging (THI)
improves the signal to noise ratio, reduces grating lobe artifacts, and improves lateral resolution.
What is the major benefit of Tissue Harmonic Imaging (THI)?
artifact reduction
B-Flow Imaging
displays the blood flow signal throughout an entire gray-scale image
can simultaneously visualize high and low velocities
detailed organ perfusion, such as renal or liver transplants, neonatal heads and superficial masses
Shear Wave Elastography
quantifies tissue stiffness
Strain Elastography
known as static or compression elastography; based on manual compression
Optimal spectral Doppler angle is ___ degrees.
zero degrees or parallel to vessel flow
zero is not always feasible; angles above 60 may result in errors of velocity calculations
Sample volume size or gate determines:
the number of blood cells sampled
Spectral analysis display demonstrates:
the direction and range of blood flow velocities in a structure of interest
Wall filter
sets the threshold or reject of low-level Doppler shift frequencies
Increasing the wall filter results in the ultrasound system being less sensitive to slow blood flow
Color Doppler displays:
mean or average Doppler velocities in a color format
Power Doppler displays:
total strength or amplitude of the Doppler signal within a specified region
represents the total number of RBCs in the region regardless of velocity
What is an artifact?
Any echo reflection anomaly in the image that does not correlate with actual tissue or structure
Posterior Acoustic Enhancement Artifact
A decrease in attenuation.
Mostly seen posterior to fluid filled structures such as cysts.
Focal Banding or Focal Enhacement Artifact
A region of echoes having increased or decreased strength, displayed across the width of an image
resolved by adjusting TGC’s
Shadowing Artifact
absence or reduction of echo signals distal or posterior to a strong reflecting structure
Indicative of calcium deposits, stones, gas, hard malignant masses, bone, etc.
Reverberation Artifact
occurs when the ultrasound beam is repeatedly reflected from an interface near the transducer
Seen as multiple equidistantly spaced linear reflections
Comet-Tail Artifact
Type of reverberation that occurs from two highly reflective interfaces and therefore echoes are closely spaced together
seen as multiple echogenic small bands (foreign bodies, surgical clips, needles, sutures, catheters, etc)
Ring Down Artifact
Type of reverberation that is thought to be a variation of comet-tail artifact; produced by small gas bubbles and appears as a single long, strong echo behind a reflector
Refraction Artifact
when the sound beam strikes adjacent interfaces of differing propagation speeds at an oblique angle; any other angle than 90 degree.
results in an incorrect location of structure
Grating Lobes Artifact
echoes placed laterally from true position
Section or Slice Thickness Artifact
Placement of echoes in the dependent portion of a fluid filled structure
Mirror Image Artifact
occurs in GS, CD and SD imaging.
near-total reflection occurs when an object is located directly in front of a highly reflective object. (diaphragm, pleura, bowel)
Aliasing Artifact
MOST COMMON artifact in Doppler Imaging
Occurs when the PRF is not high enough to sample the highest blood velocity
Color Bleeding/Blossoming Artifact
when color is seen beyond the area of interest
Color Noise Artifact
area of no flow are encoded with color
Flash Artifact
Wide region of a burst of color seen within a frame
Supine/Dorsal Decubitus
Pt lying face-up position on one’s back
Prone/Ventral Decubitus
Pt lying in face down position on one’s abdomen
Right Lateral Decubitus
lying on right side
Left Lateral Decubitus
lying on left side
Right Posterior Oblique
lying on right side at a 45 degree angle with left knee bent
Left Posterior Oblique
lying on left side at a 45 degree angle with right knee bent
Central Venous Line (CVL)
catheter is placed in a large vein in the neck, chest or leg that leads directly to the heart
Contact Precautions
Disease spreads through direct or indirect contact (open wound, draining of body fluids)
Gloves and Gown.
Droplet Precautions
Disease spread through acts such as talking, coughing and/or sneezing in which microorganisms travel no more than 3 feet from the pt
Face mask.
Airborne Precautions
Disease is spread through fine particles in the air (Tuberculosis)
Fit tested filtering face piece or a powered air-purifying respirator
Paracentesis
removal of peritoneal ascites
Thoracentesis
removal of pleural fluid
The liver, gallbladder and biliary system arise from the caudal end of the foregut during the __ week of gestation.
4th
The liver reaches its full development by age __.
15
The right lobe grows faster than the left
The ductal system is complete by the __ week of gestation.
10th
A connective tissue layer, known as ________, covers the surface of the liver and encapsulates all, but the smallest vessels in the liver.
Glisson’s Capsule
The right lobe of the liver is divided from the left lobe by:
the Main Lobar Fissure and Middle Hepatic Vein
Caudate Lobe is located ____ to the ligamentum venosum, ___ to the MPV and _____ to the IVC.
posterior to the ligamentum venosum
superior to the MPV
anterior medial to the IVC
Caudate lobe can be spared from disease due to a unique blood supply
Quadrate Lobe is located on the ___ surface of the liver and lies between the ____ and ____.
inferior surface of liver
lies between the GB fossa and falciform ligament
anterior to porta hepatis
Left lobe is separated by the caudate lobe and the ___ on the dorsal surface.
ligamentum venosum
Couinaud’s System
- Caudate Lobe
- Left Lateral Superior
- Left Lateral Inferior
4a. Left Medial Superior
4b. Left Medial Inferior - Right Anterior Inferior
- Right Posterior Inferior
- Right Posterior Superior
- Right Anterior Superior
What ligament connects the posterior liver to the diaphragm?
Coronary ligament
What ligament connects the anterior and superior surface of the liver to the anterior abdominal wall between the umbilicus and diaphragm?
Falciform Ligament
Continuous with the ligamentum teres
What ligament is continuous with the ligamentum venosum, lesser curvature of the stomach and first portion of the duodenum?
Gastrohepatic Ligament
What ligament surrounds the portal triad just proximal to the porta hepatis?
Hepatoduodenal Ligament
What ligament extends from the superior surface of the left lobe of the liver to the diaphragm?
Left Triangular Ligament
What ligament extends from the diaphragmatic surface of the right lobe to the diaphragm?
Right Triangular Ligament
What ligament is the obliterated remnant of the fetal umbilical vein?
Ligamentum Teres or Round Ligament
Originates at the umbilicus and anastomoses with the umbilical portion of the left portal vein
Liver length in neonate
4-5 cm
Liver length in adolescents
6-10 cm
Liver length in adults
15-17 cm
Neonate and young infant, liver parenchyma is ___ echogenicity of the renal cortex.
equal to
After 6 months of age, the liver parenchyma is ____ than the renal cortex.
more echogenic
Hepatic artery arises from ___ and supplies ___% of blood flow to the liver.
Celiac Trunk of the Aorta
25-30%
Hepatic artery branches into:
Proper Hepatic Artery and Gastroduodenal artery (GDA)
Before branching, the hepatic artery is referred to as the common hepatic artery.
The Proper Hepatic Artery branches into:
left and right hepatic arteries at the porta hepatis
The proper hepatic artery is ____ to the MPV and __ to the CBD.
anterior medial to MPV
medial to the CBD
Portal Vein supplies ___% of the bloody supply to the liver
70-75%
Portal Vein is formed by the confluence of the:
splenic vein and the SMV
Right Portal Vein divides into
anterior and posterior branches
Left Portal Vein divides into
medial and lateral branches
LPV connects the umbilical vein remnant through the ligament of teres
Connects the IVC through the ligament venosum which is known as the obliterated ductus venosus
Hepatic veins drain blood from the liver to the
IVC
Portal Vein size in children less than 10 years
8.5 mm
Portal vein diameter between 10-20 years
10 mm
What is the function of the liver?
- Reservoir for blood
- Removes damaged RBCs and bacteria by phagocytosis
- Reticuloendothelial cells (Kupffer cells) responsible for clearing pathogens - Metabolizes lipids, proteins, and carbs into energy sources
- Nutrient, mineral and vitamin storage
- Formation and Excretion of Bile
LFT’s (Liver Function Tests)
evaluate liver function and liver injury
ALT (Alanine aminotransferase)
an increase in ALT values indicates damage to the liver usually from hepatitis, hepatocellular disease, or biliary tract obstruction.
AST (Aspartate Aminotransferase)
Increases with hepatocellular disease as well as indicating skeletal and muscular damage
used for detecting liver damage due to hepatitis and cirrhosis
ALP (Alkaline Phosphatase)
increase in ALP indicates liver or bone disease
Children and Adolescents often have an increase in ALP because their bones are still developing and growing.
MOST SPECIFIC INDICATOR OF BILIARY OBSTRUCTION
Paget’s disease, a condition causing excess bone growth and formation, will have an increase in ALP.
Direct or Conjugated Bilirubin
Increase in direct bilirubin is associated with decreased hepatic excretion, hepatitis, cholestasis and biliary obstruction
Indirect or Unconjugated Bilirubin
Increase associated with hemolytic anemia, hepatitis and cirrhosis
Total Bilirubin
can be high in newborns due to physiologic jaundice but usually resolves itself in a few days.
Biliary Atresia can cause an increase in total bilirubin and unconjugated bilirubin
AFP (Alpha Fetoprotein)
used as a tumor marker to detect hepatomas and hepatoblastomas
associated with chronic liver disease and chornic hep B or C
Liver/GB/Pancreas Ultrasound NPO Prep for less than 4 years
NPO for 4 hours
Liver/GB/Pancreas Ultrasound NPO Prep older than 4
NPO for 5-6 hours
Reidel’s Lobe Variant
a tongue-like project of the right lobe that extends to the iliac crest
more common in females
Left Lobe Position Variant
left lobe may be located to the right of midline or may extend to the left lateral abdominal wall
Heterotaxy Syndrome (Situs Ambigus)
Associated with:
Sonographic findings:
disturbance in the usual location of the right and left distribution of the abdominal and thoracic organs
Associated with polysplenia, asplenia, cardiac defects, biliary atresia
Variable Sonographic findings:
- liver located in midline
- azygos or hemiazygous continuous of IVC
- PV and IVC variations may be seen
Caroli’s Disease
Associated with:
Clinic Presentation:
Sonographic Findings:
Congenital disorder resulting in multifocal cystic dilation of the intrahepatic bile ducts as a result of congenital hepatic fibrosis
Associated with fibropolycystic liver disease and polycystic kidney disease
Clinical:
- Intermittent RUQ pain
- Jaundice
- Fever
Sonographic:
- Polycystic Liver Disease
- Dilated Intrahepatic Ducts
- Intraductal Calculi
- Small PV branches with dilated bile ducts
Cystic Fibrosis
Clinical:
Sonographic Findings:
Results in replacement of pancreatic tissue with fibrosis and fat; autosomal recessive disorder
Clinical:
- Failure to thrive
- abdominal pain
- Jaundice
Sonographic:
- Increased liver echogenicity
- Micro or macro cysts on pancreas
- Small GB and cholelithiasis
Niemann-Pick Disease
Risk Factors:
Clinical:
Sonographic:
lipid storage disease; results in accumulation of lipids in brain, spleen, liver, lungs and bone marrow
Risk factors:
- inherited
- female
- fatal
Clinical:
- neurological symptoms
- feeding and swallowing issues
- elevated LFTs
Sonographic Findings:
- Hepatosplenomegaly
- Increased liver echogenicity
- Enlarged nodes
Gaucher Disease
Risk Factors:
Clinical:
Sonographic:
lysosomal storage disease which results in increased glucosyleramide
Risks:
- Jewish population
- Autosomal recessive disorder
Clinical:
- Hepatosplenomegaly
- Abdominal pain
- growth retardation
Sonographic:
- Increased liver echogenicity
- hepatosplenomegaly
- nodular spleen
Non-Alcoholic Fatty Liver Disease (NAFLD)
Associations:
Sonographic Findings:
Chronic liver condition due to hepatic fat accumulation or steatosis
Associations:
- Portal HTN
- Cirrhosis
- Hepatocellular Carcinoma
Sonographic Findings:
- Hepatomegaly
- Diffuse or focal areas of parenchymal echogenicity
- The walls of the portal veins blend in due to the increasing parenchymal echogenicity
Non-Alcoholic Steatohepatitis (NASH)
Fat accumulation plus inflammation, fibrosis and necrosis
What is the most common form of chronic liver disease in children?
Non-Alcoholic Fatty Liver Disease
Reye’s Syndrome
Disorder characterized by fatty infiltration of the liver and encephalopathy
Typically occurs in young children following a previous viral infection : cold, flu, chicken box, use of aspirin
Glycogen Storage Disease
Sonographic Findings:
Excessive glycogen accumulates in the organs (Type 1 or Von Gierke’s disease occurs in the neonatal period)
Sonographic:
- Increased liver echogenicity
- Hepatomegaly
- Associated liver cell adenomas
What is the most common inborn error of carbohydrate metabolism?
Glycogen Storage Disease
Cirrhosis
Risk Factors:
Clinical:
Sonographic:
Disease in which liver tissue is replaced with fibrotic scar tissue
Risk Factors:
- Biliary Atresia
- Cystic Fibrosis
- Chronic Hepatitis
Clinical:
- Hepatomegaly
- Jaundice
- Increase in bilirubin and LFT’s
- Ascites
Sonographic:
- Decreased liver size
- Nodular Surface
- Heterogenous Parenchyma
- Nodules
- Portal HTN
- Splenomegaly
- Ascites
Abscess
Collection of Pus
In infants, ____ are associated with infection from the umbilicus or mesentery.
Abscesses
Abscess associated with living conditions which have contaminated drinking water.
Amebic
Abscess secondary to infections from the bowel, trauma, or surgery.
Pyogenic
Abscess that occurs in immunocompromised patients and are usually due to candida albicans.
Fungal
Cavernous Hemangioma
Sonographic Findings:
large network of vascular endothelium-lined spaces filled with RBCs
occurs in older children and adolescents
Sonographic:
- Hyperechoic
- Single or Multiple
- Posterior Acoustic Enhacement
- Color & Spectral show slow flow
Hemangioendothelioma
Clinical:
Sonographic Findings:
benign mass composed of vascular spaces lined by several layers of endothelial cells
Typically diagnosed before 6 months of age
Clinical:
- hemangiomas of the skin
- abdominal distention
- ongestive heart failure
- Increased AFP
Sonographic:
- well defined
- hypoechoic nodule but can appear hyperechoic with cystic changes
- single or multiple
- Hepatic veins can be enlarged due to increased flow
What is the most common symptomatic vascular lesion of the liver?
Hemangioendothelioma
Mesenchymal Hamartoma
Sonographic Findings:
rare, benign tumor derived from periportal connective tissue or mesenchyme
Children less than 2
Sonographic Findings:
- large lesions
- complex
- poorly circumscribed
- swiss cheese appearance of liver
- avascular
Focal Nodular Hyperplasia (FNH)
Clinical:
Sonographic Findings:
mass comprosed of abnormally arranged hepatocytes, Kupffer cells, bile duct elements and fibrous connective tissue
Clinical:
- Hx of chemotherapy for neoplastic diseases
- enlarged mass may cause pain
- asymptomatic
Sonographic Findings:
- Solitary
- Well circumscribed
- Isoechoic to liver
- Central echogenic scar
- Peripheral blood flow and blood flow within mass
Hepatic Adenoma
Clinical:
Sonographic Findings:
Mass composed of abnormal hepatocytes
Clinical:
- Von Gierke’s disease or Type 1 glycogen storage disease
- asymptomatic
- pain may occur if mass bleeds
Sonographic Findings:
- Solitary
- well defined
- variable appearance
- peripheral flow and blood flow within
Hepatoblastoma
Clinical:
Sonographic Findings:
Malignant neoplasm of the liver (infant to 5 years)
Clinical:
- Associated with children with predisposing conditions
- most common indication is painless abdominal mass with elevated AFP levels
Sonographic:
- Hepatomegaly
- well defined mass
- heterogenous
- high velocity, low resistant flow pattern
What is the most common primary liver tumor in children?
Hepatoblastoma
Treatment of Hepatoblastoma depending on Staging
Stage 1: complete resection
Stage 2: resection with microscopic residual disease
Stage 3: resection with residual tumor, positive lymph nodes
Stage 4: metastic involvement
Hepatocellular Carcinoma
Clinical:
Sonographic Findings:
Primary malignancy of the liver
Clinical:
- over 3 years old
- preexisiting liver disease
Sonographic:
- solid, hyperechoic mass
- large
- well defined or ill defined borders
- tumor invasion or thrombus of Portal Vein
Lymphoma
Clinical:
Sonographic Findings:
Malignant neoplasm of the lymphatic system
Liver, Renal and Testicular involvement typically from Non-Hodgkin’s Lymphoma
Lung/Thymus involvement typically Hodgkin’s Lymphoma
Clinical:
- asymptomatic lymph node enlargement
- abnormal pressure and congestion in the face, neck and chest
- children over 5
Sonographic:
- Focal mass
- well-defined
- variable appearance
What is the most common malignancy to involve the spleen in children?
Lymphoma
Leukemia
Clinical:
Sonographic:
Malignant disease involving the blood-forming tissues (bone marrow, lymph nodes and spleen)
Testicular involvement may occur at the same time of initial involvement or may occur after bone marrow remission
Clinical:
- characterized by an abnormal increase in WBC
- easy bruising or bleeding
- non healing of minor wounds
Sonographic:
-Hypo or Hyperechoic lesions
Mets to the liver are typically from what malignant tumors?
Neuroblastoma
Wilm’s Tumor
Leukemia
Lymphoma
Portal Hypertension
Sonographic Findings:
Portal venous pressure exceeding 5 mmHg or portal vein to hepatic vein gradient greater than 10 mmHg
Caused by a disruption of the flow through the portal system (PV thrombosis)
Sonographic:
- Dilated MPV greater than 13mm
- Recanalized ligamentum venosum and/or ligamentum teres
- Hepatosplenomegaly
Treatment includes portosystemic shunts to reduce pressure within the portal system
In children portal hypertension is most commonly due to:
intrahepatic etiologies, cirrhosis and liver disease
Portal Vein Thrombosis
Clinical:
A total or partial obstruction of blood flow within the portal vein due to the formation of a thrombus
Cavernous Transformation occurs to bypass thrombotic site, hepatofugal flow happens because the collaterals can’t release the systems pressure
Clinical:
- trauma
- neonatal peritonitis
- umbilical catheterization
- sepsis
Hematoma
Sonographic Findings:
a collection of blood within or adjacent to liver usually from trauma
Commonly located in posterior segment of right lobe
Variable appearance based on age of hematoma
Biloma
collection of bile in the liver or peritoneal cavity which is a late complication of hepatic trauma
Sonographic findings:
- anechoic collection of fluid
- thin walled
- resolve spontaneously
What normal variant of the GB represents a bulge on the inferior surface of the infundibulum where stones can become impacted and obstruct the cystic duct?
Hartman’s Pouch
Size of GB less than 1 year of age (length and wall thickness)
Length: 1.5-3 cm
Wall: less than 3 mm
Size of GB older than 1 year of age (length and wall thickness)
Length: 3-7 cm
Wall: less than 3 mm
What duct joins the neck of the GB to the common hepatic duct (CHD)?
Cystic Duct
What is the accessory cystic duct?
Duct of Luschka
Associated with bile leaks following surgical procedures
Duct formed by the junction of the cystic duct and the common hepatic duct
Common Bile Duct (CBD)
Cystic Duct Size
1-5 mm in diameter
CBD Size Neonates: Children up to 1 year: 1-10 years: Adolescents and Young Adults:
Neonates: <1mm
Children up to 1: <2mm
1-10 years: <4mm
Adolescents/Yound Adults: <6mm
Where is bile stored in patients with a cholecystecomy?
proximal small intestine
after eating, the acids are then transported to the distal ileum for absorption and maintenance
What is the most common GB variant?
Junction fold - a fold at the GB neck
What is a fold at the GB fundus?
Phrygian Cap
Gallbladder Agenesis
complete absence of the GB with normal bile ducts
Biliary Atresia
Clinical:
Sonographic Findings:
Congenital obstruction of biliary system that can affect intra or extrahepatic ducts
Clinical:
- males
- jaundice
- acholic stools
Sonographic:
- GB may or may not be affected (abnormal looking GB if affected)
- “Triangle Cord Sign” : seen superior to PH which is a premature bile duct
Kasai Procedure and Liver Tx are treatments
Triangle Cord Sign
Echogenic structure resembling a triangle that is found superior to porta hepatis.
Sign of biliary atresia
Choledochal Cyst
Clinical:
Sonographic Findings:
Cystic dilation of the biliary tree
Clinical:
- Asian population
- Female
- Biliary Atresia
Sonographic:
- Saccular dilation of the CBD or CHD
- dilated cystic lesion that communicates with the bile ducts and is separate from the GB
Caroli’s Disease
Congenital disorder resulting in multifocal dilation of the intrahepatic ducts as a result of congenital hepatic fibrosis
Associated with polycystic liver and kidney disease
Cholelithiasis is most commonly seen in what age group?
Adolescents
GB Hydrops
massive distention of the GB in the absence of inflammation
Greater than 3cm in length in children less than 1 and greater than 7 cm in length in older children
Neonatal Cholestasis
Clinical:
Sonographic Findings:
Conjugated hyperbilirubinemia occurring in neonates
Clinical:
- jaundice
- acholic stools
- dark yellow urine
Sonographic:
- Dilation of the biliary ducts
- Gallstones
- Sludge
Acalculus Cholecystitis
Clinical:
Sonographic Findings:
Inflammation of the GB without gallstones
Clinical:
- critcally ill patients
- RUQ pain
- Fever/Vomiting
Sonographic:
- Edematous GB wall
- GB wall measures >3mm
- Pericholecystic Fluid
- GB Distention
Acute Calculus Cholecystitis
Clinical:
Sonographic Findings:
An acute inflammation of the GB usually from GB obstruction at the level of the cystic duct or GB neck
Clinical:
- RUQ pain
- Fever/Nausea/Vomiting
Sonographic:
- GB wall thickening
- Sludge
- Pericholecystic Fluid
- Hyperemia
- Positive Sonographic Murphy’s Sign
What is the most common cause of RUQ pain?
Acute Calculus Cholecystitis
Chronic Cholecystitis
Sonographic Findings:
Prolonged inflammatory condition that is caused by intermittent blockage of the cystic duct
Sonographic Findings:
- Contracted GB
- Stones
- Thick, hyperemic wall
- Sludge
Sclerosing Cholangitis
Sonographic Findings:
Inflammatory fibrosis of intra and extra hepatic ducts
Sonographic Findings:
- Dilated bile ducts
- Thickened bile duct walls
- Choledocholithiasis
- Cholelithiasis
Choledocholithiasis
Complete or partial obstruction of the bile ducts by biliary stones
large foci may cause intra or extra hepatic ductal dilatation
Mirizzi Syndrome
Extrahepatic biliary obstruction due to impacted cystic duct and associated extrinsic compression or inflammation of the cystic duct
Bile Plug Syndrome
Extrahepatic bile duct syndrome due to sludge
Echogenic debris within bile ducts
Rhabdomyosarcoma Liver/Renal
Clinical:
Sonographic Findings:
Rare malignant tumor made up of muscle tissue that arises from the porta hepatitis/trigone of bladder
usually found in children between 2-6 years and 14-18 years
Clinical: -obstructive jaundice -abdominal pain -weight loss elevated bilirubin, Alkaline phosphatase and WBC
Sonographic:
- echogenic mass within bile ducts
- may appear complex due to necrosis or hemorrhage
- absence of posterior shadowing
Granular Cell Tumor
Clinical:
Sonographic Findings:
non-epithelial tumor of the extrahepatic ducts
Clinical:
- female
- African American
- Adolescents
- jaundice
- abdominal pain
Sonographic:
- echogenic mass within the bile ducts
- may appear complex due to necrosis or hemorrhage
- absence of posterior shadowing
At approximately __ weeks of gestation the pancreas arises from two outpouchings on the endodermal lining of the duedenum dorsal wall.
5
The pancreas is a ____ organ located in the ___ pararenal space, ___ to the lesser sac.
Retroperitoneal
anterior
posterior
Pancreatic head is located
___ to the SMV.
____ to the IVC
____ to the MPV.
right lateral to the SMV
Anterior to the IVC
caudal to the MPV
The GDA is situated at the ____ border of the pancreatic head and the distal portion of the CBD lies ___ to the head.
GDA: anterior lateral
CBD: posterior lateral
What is the main pancreatic duct?
Duct of Wirsung
located within head and body of pancreas and merges with CBD
What is the accessory duct of the pancreas?
Duct of Santorini
Small branch of main pancreatic duct and located within head of panc
Main Pancreatic Duct Measurements
3 mm in the head
2 mm in the body
Which organ is an exocrine and an endocrine organ?
Pancreas
Exocrine: glands that secrete hormones through ducts
Endocrine: glands that secrete hormones without ducts
Pancreatic enzymes (exocrine):
Lipase breaks down ___.
Trypsin breaks down ___.
Amylase breaks down ____.
Lipase - fat
Trypsin - proteins
Amylase - carbohydrates
What hormones are released when food enters the GI tract?
Cholecystokinin, gastrin and secretin
What are the endocrine cells of the pancreas?
Islet cells of Langerhans
Pancreatic hormones (endocrine)
Alpha cells secrete ___.
Beta cells secrete ___.
Delta cells secrete ___.
Alpha - glucagon
Beta - Insulin
Delta - Somatostatin
Elevated serum and urine ____ values may indicate acute pancreatitis, pancreatic pseudocyst, intestinal obstruction, or mumps.
Amylase
Elevated levels of ___ indicate damage to the pancreas.
Lipase
An increase in ____ may indicate severe diabetes, chronic liver disease or over activity of the endocrine glands.
Glucose
Annular Pancreas
Clinical:
Sonographic Findings:
Pancreatic head encircles the duodenum
Clinical:
- partial or complete duedenal atresia
- males
- asymptomatic
- vomiting
Sonographic:
-circumferential band of tissue surrounding the duodenum
Pancreatic Divisum
Clinical:
Sonographic Findings:
Complete or incomplete fusion of the pancreatic ducts
Complete: 2 seperate pancreatic duct systems
Incomplete: small branch between dorsal and ventral pancreatic ducts
Clinical:
- pancreatitis
- pancreatitis symptoms
Sonographic:
- difficult to visualize
- normal to enlarged pancreatic head
What is the most common pancreatic congenital variant?
Pancreatic Divisum
Ectopic Pancreatic Tissue
Clinical:
Presence of pancreatic tissue outside of the pancreas (greater curvature of stomach, pylorus, duodenal bulb, prox jejunum, ileum, Meckel’s diverticulum)
Clinical:
- severe epigastric pain
- biliary disease
- weight loss
Von Hippel-Lindau (VHL)
Sonographic Findings:
Tumors arising from multiple organs
Pancreatic cysts are a common lesion of VHL (Type 1 is NOT associated with pheochromocytomas and Type 2 is associated with pheochromocytomas)
Sonographic:
-anechoic fluid filled pancreatic mass(es) with through transmission
Shwachmann-Diamond Syndrome
Sonographic Findings:
congenital anomalies, exocrine pancreatic dysfunction, bone marrow failure, metaphyseal dysostosis and swarfism.
Sonographic:
Hyperechoic pancreas with variable size
Acute Pancreatitis
Clinical:
Sonographic Findings:
Sudden on set of inflammation to part or all of the pancreas
Clinical:
- elevated amylase
- elevated lipase
- eleaved WBC
- trauma
- hereditary
- viral infections
Sonographic:
- diffusely enlarged pancreas
- possible lymph nodes seen
- fluid collections
- abscess
- pseudocysts
Chronic Pancreatitis
Clinical:
Sonographic Findings:
Relapsing pancreatitis resulting in pancreatic fibrosis and destruction of pancreatic cells
Clinical:
- abdominal pain
- jaundice
Sonographic:
-calcifications
heterogenous
-increased echogenicity
Pancreatic Pseudocyst
Clinical:
Sonographic Findings:
Fluid collection of pancreatic enzymes with a fibrous capsule
Clinical:
- acute pancreatitis symptoms
- abdominal pain
- elevated amylase
Sonographic:
- variable location
- single or multiple
- well defined walls with variable internal appearance
Pancreaticoblastoma
Clinical:
Sonographic Findings:
Malignant neoplasm of the acinar cells of the pancreas
Clinical:
- occurs in the first decade
- males
- asian descent
- beckwith-wiedemann syndrome
- favorable outcome
Sonographic Findings:
- large
- well defined mass
- variable appearance
- vascularity within the mass
Adenocarcinoma
Clinical:
Sonographic Findings:
Aggressive malignant neoplasm arising from the ductal epithelium of acinar cells
Clinical:
- Diabetes
- Chronic Pancreatitis
- Abdominal pain
Sonographic Findings:
- poorly defined hypoechoic mass
- biliary and pancreatic duct dilatation
Islet Cell Tumor
Arise from the tissue of the Isles of Langerhans
Functional tumors: increased amounts of hormones
Nonfunctional tumors: may go undetected until they produce a palpable mass
Different types of Islet Cell Tumors:
Insulinoma (usually benign)
Gastrinoma (rare, malignant with mets to liver)
Nonfunctioning Tumors (malignant potential)
What is the most common type of Islet Cell Tumor?
Insulinoma
Types of trauma to the pancreas:
Sonographic Findings:
- Hematoma
- Laceration
- Fracture
- Posttraumatic pancreatitis
Sonographic Findings:
- pancreatic enlargement
- edematous pancreas
- fluid collections
- linear areas representing fractures or lacerations
Development of the urinary tract begins at ___ weeks.
4
What are the 3 sets of kidneys during the early development?
Pronephros
Mesonephros (functional embryonic kidney)
Metanephros (permanent kidney)
What do the pronephros regress?
When do the mesonephros regress?
When do the Metanephros regress?
Pronephros regress at 4 weeks.
Mesonephros regress at 9 weeks.
Metanephros develop into the permanent kidneys.
The kidneys develop in the pelvis and ascent into the abdomen. By what week are the kidneys in the normal position?
By 15-20 weeks gestation
Renal lobes are formed by the __ week of gestation.
28th
Kidney length:
Neonates
5 years
10+ years
Neonates: 3.4-5 cm
5 years: 5-8 cm
10 years: 6-11 cm
Large kidneys are defined as 2 standard deviations above the mean.
Small kidneys are defined as 2 standard deviations below the mean.
Newborn sonographic appearance of kidneys:
Cortex is more echogenic than the liver and spleen.
Sinus is not echogenic due to the lack of fat.
Pyramids are hypoechoic and triangular in appearance.
Infant greater than 6 months of age sonographic appearance of kidneys:
Cortex is hypoechoic to liver and spleen.
Increased echogenicity of sinus.
The renal artery enters the kidney hilum ___ to the ureter and ___ to the renal vein.
anterior to the ureter
posterior to the renal vein
so from anterior to posterior:
Renal Vein
Renal Artery
Ureter
Arterial System of Kidneys
Main renal artery -> segmental -> interlobar -> arcuate -> interlobular -> afferent arterioles
Venous System of Kidneys
Efferent arterioles -> interlobular veins -> arcuate veins -> interlobar veins -> segmental veins -> main renal vein
Layers of the bladder wall:
Serosa - outer layer
Muscle - middle layer
Mucosa - inner layer
Bladder wall thickness in a distended and non-distended bladder:
Distended: 3 mm
Non-Distended: 5 mm
Creatinine aids in determining ___.
Renal dysfunction
___ levels increase in acute or chronic disease, renal damage, and renal failure.
BUN (blood urea nitrogen)
Urinalysis are used to detect ___.
Chronic Renal Disease
Fetal Lobulation
Contour lobulation persisting after 5 years of life
Scalloped contour may appear similar to a cortical mass
Extrarenal pelvis
A renal pelvis that is normally positioned within the kidney sinus appears to bulbously extend outward in the absence of urinary tract obstruction
Column of Bertin
An inward extension of the cortex between the renal pyramids extending into the sinus
Mimics the appearance of a renal mass and splays the calyces
Dromedary Hump
A cortical bulge found on the lateral aspect of the left kidney
May be referred to as a pseudo tumor
Simple Ectopic Kidney
Results when the kidney fails to migrate into the renal fossa
Pelvic Kidney which can be small and malrotated
Crossed Ectopic Kidney
Both kidneys located on the same side of the spine; left kidney is typically located on the right
Ectopic kidney lies inferior to the normally positioned kidney and the upper pole of the ectopic kidney is fused to the lower pole of the normal kidney.
Unilateral Renal Agenesis
congenital absence of the kidney with the presence of a normal adrenal gland
Associated with chromosomal abnormalities and genito anomalies
High blood pressure may be present
Bilateral Renal Agenesis
Absence of both kidneys
Associated with Potter’s syndrome, oligohydramnios in uteruo and pulmonary hypoplasia
Fatal
Horseshoe Kidney
Fusion of the right and left kidneys which usually occurs at the lower poles
What is the most common renal anomaly?
Horseshoe Kidney
Renal Hypoplasia
A congenital small functioning Kidney
Unilateral - asymptomatic
Bilateral - hypertension, VUR
Duplex Collecting System
incomplete fusion of the upper pole moiety resulting in a complete or incomplete duplication of the renal collecting system
What is the most common urinary tract anomaly?
Duplex Collecting System
Patent Urachus
The urachus from the anterior bladder wall to the umbilicus remains open
Urachal Sinus Tract
Portion of the urachus at the umbilical end is open and the portion closest to the bladder is closed.
Urachal Cyst
Urine is trapped in the middle portion of the urachus
Urachal Diverticulum
Portion of the urachus at the umbilical end is closed and the portion closest to the bladder is open.
Megacystis
Enlarged bladder
Megacystis-Megaureter
Enlarged bladder and ureters
Megacystis-microcolon-hyperperistalsis syndrome
Enlarged bladder, ureters and renal pelvis
Dilated small bowel
Small colon
Hydronephrosis
Grading:
Failure of urine to drain from the kidney resulting in dilatation of the renal pelvis and calyces.
Grade 1: dilatation of the renal pelvis only
Grade 2: dilatation of the renal pelvis and some of the calices
Grade 3: dilatation of the renal pelvis and all of the calices
Grade 4: dilatation of the renal pelvis, all of the calices plus parenchymal thinning
Ureteropelvic Junction (UPJ) Obstruction
Obstruction of urinary flow due to an instrinsic narrowing at the UPJ level
Arise from calculi, infections such as pyelonephritis and hemorrhage
Dilated renal pelvis and/or calyces with a collapsed proximal ureter
What is the most common congenital urinary tract obstruction?
UPJ Obstruction (Ureteropelvic Junction)
Ureterovesical Junction (UVJ) Obstruction
obstruction of urinary flow at the insertion of the ureter into the bladder
neurogenic bladder in children with spinal anomalies and bladder outlet obstruction or PUV
Posterior Urethral Valve (PUV) Obstruction
Sonographic Findings:
Obstruction of urinary flow at the level of the posterior urethra valve in the urethra (results from an abnormal mucosal flap, fold or urethral tissue)
Sonographic:
- Hydro
- Dilated ureters
- Thin, hyperechoic parenchyma
- Loss of corticomedullary differentiation
- trabeculated, thick walled bladder
- keyhole bladder
What is the most common congenital urethral obstruction in male children?
PUV Obstruction
Multicystic Dysplastic Kidney
Sonographic Findings:
Congenital, non hereditary cystic renal disease
MCDK will eventually involute and the contralateral kidney will compensate for renal function.
If bilateral, the result is fetal demise.
Sonographic:
- Multiple anechoic cysts of varying sizes throughout kidney
- renal parenchyma not visualized
- large kidney progressing to unidentifiable kidney with increasing age
Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Sonographic Findings:
Bilateral symmetric microcystic disease
Also known as infantile polycystic kidney disease
Sonographic:
- enlarged, echogenic, normal shaped kidneys
- microcysts in medulla and cortex
- medullary pyramids appear hypoechoic in the early stage and become hyperechoic with a loss of corticomedullary differentiation later on
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Sonographic Findings:
Uni or bilateral cystic disease
Also known as adult polycystic kidney disease (often associated with 4th decade of life)
Sonographic:
- enlarged, lobulated kidneys
- cysts of different sizes
- renal parenchyma between the cysts is normal
- normal tissue may become compressed due to cysts and later atrophy
Renal Dysplasia
Sonographic Findings:
Abnormal development of kidneys in the womb leading to abnormal kidneys
Associated with Prune Belly Syndrome and Eagle-Barrett Syndrome
Sonographic:
- kidneys will appear large or small
- abnormal renal parenchyma
- may or may not have renal cysts
- dilated renal collecting system or pelvis
Pyelonephritis
Sonographic Findings:
Infection of the upper urinary tract
Sonographic:
- normal to enlarged kidneys
- areas of increased or decreased echogenicity
- absence of perfusion
- loss of corticomedullary differentiation
Nephrocalcinosis
Sonographic Findings:
Calcium deposits in both kidneys
Seen in neonates with a metabolic disorder, which allows for the formation of calcium deposits later in life
Sonographic:
- echogenic pyramids
- shadowing may or may not be present
Renal Angiomyolipoma
Sonographic Findings:
Benign renal tumor composed of blood vessels, smooth muscle cells and fat cells. It is usually associated with Tuberous Sclerosis.
Sonographic:
- multiple hyperchoic masses in renal cortex
- cysts may be seen
- renal enlargement
Mesoblastic Nephroma (Fetal Renal Hamartoma)
Sonographic Findings:
Mass typically seen in the hilar region usually found in infants younger than 3 months.
Sonographic:
- Solid well defined lesion
- may appear cystic with changes due to hemorrhage or necrosis
- distorted collecting system or parenchyma
chemo is used if lesion is not completely resected. Surgery often requires a complete nephrectomy.