Pedia Topnotch Flashcards
Immediate goal of immunization
Prevention of disease
Ultimate goal of immunization
Eradication of disease
Two types of immunization
Active and passive
Types of antigen for active immunization
- Live attenuated
2. Inactivated
What are the live vaccines? List 7.
BCG Measles MMR Varicella Rotavirus Influenza intranasal Typhoid fever
Peak of passive immunization for IM injections
48-72 hrs
System for ensuring the potency of a vaccine from the time of manufacture to the time it is given to a child
Cold chain
When can combination vaccines be given simultaneously?
- Equal or >2 inactivated vaccines
2. Inactivated and live vaccines
What is the rule in giving live vaccines in combination?
28-day minimum interval if not given simultaneously
What is the principle in lapsed immunization?
does not require reinstitution of the entire series. subsequent immunizations should be given at the next visit as if the usual interval has elapsed.
Only vaccine given intradermally
BCG
When is BCG usually given?
earliest possible age after birth preferrably within the first 2 months
If BCG is not given in the first 2 months what do we do?
PPD vaccination is NOT recommended prior to vaccination.
PPD is however required if the following conditions are present:
- suspected congenital TB
- history of close contact to know TB case
- clinical findings suggestive of TB or xray suggestive of TB
What is a positive PPD test in those requiring PPD before vaccination?
> 5mm induration
What is the dose of BCG?
12 mos - 0.1 ml
Measles vaccine is given through what route
SQ
Measles vaccine is given at
9 months
Measles vaccine can be given as early as ___ in cases of outbreaks as declared by PH officials
6 months
Common adverse effects of BCG vaccine
Abscess or ulcers at site
Axillary Lymphadenopathy
Dose of measles vaccine
0.5ml
Common adverse effect of measles vaccine
fever 5-12 days after vaccination
rash
A 14 year old male presents with joint pains and morning stiffness for the past 3 months. The joint pain is present in both hands and feet bilaterally. On PE, joints are tender to palpation, warm, and swollen. What is the most likely diagnosis?
Juvenile Rheumatoid Arthritis
3 prinicipal types of onset of JRA
- Oligoarthritis (pauciarticular)
- Polyarthritis
- Systemic-onset disease
HLA subtypes in JRA
HLA DR4 (Polyarticular) HLA DR8 and DR5 (Pauciarticular)
Criteria of classification of JRA
Age <16years
Arthritis (2 or more of the following) limitation of ROM, tenderness or pain on motion, increased heat in one or more joints
Onset type of JRA is defined by disease characteristic in the first _months
6 mos
JRA classifications, differentiate each:
- Polyarthritis - 5 or more inflamed joints
- Oligoarthritis: <5 inflamed joints
- Systemic arthritis: with characteristic fever
Characteristic of fever in systemic onset JRA
quotidian fever with daily high spikes and rapid return to baseline usually associated with a faint red macular rash (salmon pink rash)
Treatment of JRA
NSAIDs
Methotrexate and immunosuppresive agents
Steroids for overwhelming systemic illness
Physical and occupational therapy
Inflammation if the joints of the axial skeleton and limbs, presence of enthesitis (inflammation of the sites of attachments of ligaments, tendons, fascia, and capsule to bone), absence of Rheumatoid factor
Ankylosing spondylitis
Demographic of people with ankylosing spondylitis
older boys, adolescents, young adults
HLA type found in >90% of people with ankylosing spondylitis
HLA-B27
Forms of ankylosing spondylitis (3)
- Juvenile (oligoarthritis legs>arms, enthesitis, hip joint arthritis, back pain, loss of spinal flexibility
- Psoriatic (oligoarthritis, asymmetric, nail pitting, dactylitis, FH of psoriasis)
- Reactive (Reiter syndrome: arthritis, conjunctivitis, urethritis), lower limb arthritis
Eye complication of ankylosing spondylosis
Anterior uveitis (Iridocyclitis) 25%
Treatment for ankylosing spondylosis
NSAID and may add sulfasalazine
Intraacrticular triamcinolone
Criteria for diagnosis of SLE
4 out of 11
SOAP BRAIN MD
Serositis (Pleuritis, Carditis)
Oral Ulcers (painless)
Arthritis (2 or more joints)
Photosensitivity
Blood Changes (anemia, leukopenia, thrombocytopenia) Renal Disorder (persistent proteinuria,cellular casts) ANA abnormal titer Immunological Changes (anti dna, Ab, Anti Sm) Neurologic signs (seizures, frank psychosis)
Malar rash
Discoid rash
screening for SLE
ANA
more specific marker for lupus and reflects degree of disease activity
anti dsdna
Complement low in lupus
low C3, C4
marker only found in SLE
anti Smith Ab
Route of rotavirus vaccine
oral
RV1 and RV5 number of doses, schedule, interval between doses and brands
RV1 (monovalent) Rotarix 2 doses
RV5 (pentavalent) RotaTeq 3 doses
between 6 weeks and 32 weeks (8mos)
interval between doses: 4 weeks
MMRV:
Route?
How many doses?
Schedule between ?
Minimum interval between doses?
Route? SQ
How many doses? 2 doses
Schedule between ? 12 mos-12 years
Minimum interval between doses? 3 mos
Definition of hematuria
More than 5 rbcs/hpf
Dipstick test for hematuria is based on what chemical reaction?
Peroxidase reaction with hemoglobin
Is cloudy urine always abnormal?
No. It can be due to crystal formation at room temp.
Tea colored urine usually points out to a ___ problem
Glomerular
Normal specific gravity
1.015-1.025
What crytals form in acidic urine?
Uric acid
What crystals form in basic urine?
Phosphate crystals
Positive dipstick but absent rbcs in urine. What is the usual cause?
Myoglobinuria from rhabdomyolysis
Primary treatment in SLE
Prednisone 1-2mg/kg/day
Severely ill: Pulse IV steroids (30 mg/kg/dose max 1 gm over 60mins OD for 3 days)
Severely ill: pulse IV cyclophosphamide to maintain renal function and prevent progression
Most common of the pediatric inflammatory myopathies
Dermatomyositis
HLA subtype association in Dermatomyositis in >80%
HLA Ag DQA1*0501
Systemic vasculopathy with cutaneous findings and focal areas of myositis resulting in progressive muscular weakness that is responsive to immunosuppressive therapy
Dermatomyositis
Usual risk factor and infection triggers of Dermatomyositis
Sun exposure
Enterovirus (Coxsackievirus B) and GABHS
Periorbital violaceous erythema common in Dermatomyositis
Heliotrope rash
Skin finding over the metacarpal and proximal interphalangeal joints that is hypertrophic and pale red with a papular, alligator-skin like appearance seen in dermatomyositis
Gottron papules
Severe prognostic sign in dermatomyositis
Dysphagia
A chronic disease characterized by fibrosis affecting the dermis and arteries of the lungs, kidney, and GIT
Scleroderma
Pathophysio of Scleroderma
Injury of vascular endothelium leading to fibrosis
Earliest manifestation of scleroderma and may precede skin and internal organ involvement by months or years.
this is not however limited to scleroderma but can also herald other diseases such as connective tissue disorders, rheumatic disorders and other immunologic conditions
Raynaud phenomenon
excessively reduced blood flow in response to cold or emotional stress, causing discoloration of the fingers, toes, and occasionally other areas
Components of CREST Syndrome
Calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia.
Is a systemic connective tissue disease.
Characteristics include essential vasomotor disturbances; fibrosis; subsequent atrophy of the skin, subcutaneous tissue, muscles, and internal organs (eg, alimentary tract, lungs, heart, kidney, CNS); and immunologic disturbances accompany these findings.
Systemic sclerosis (SSc)
Diagnostic Criteria of Systemic Sclerosis
Major criterion or 2 of the 3 Minor criteria
Major Criteria:
1. Proximal scleroderma: typical skin changes (tightness, thickening, non-pitting induration excluding localized forms) involving areas proximal to the MCP or MTP joints
Minor Criteria
- Sclerodactyly
- Digital pitting scars from digital ischemia
- Bibasilar pulmonary fibrosis not attributable to primary lung disease
Antibody finding mostly suggestive for scleroderma
Anti-SCL70 specific for topoisomerase 1 and anticentromere autoantibodies
Drug used that may prevent ulcerations in scleroderma
ACE inhibitors
Imunosuppresive agents used in scleroderma
Methotrexate and steroids
How many percent of coronary aneurysms in Kawasaki disease resolve after 1-2 years?
50%
IgA mediated vasculitis of the small vessels
HSP
Typical Prodrome of HSP
typically follows after an URTI
Pathophysio of HSP
IgA deposition in blood vessels that cause leaking –> purpura and petechiae
HLA subtype common in HSP
HLA-DRB1*07
Organ systems primarily affected in HSP
Skin, GI, Kidney
Hallmark rash of HSP
palpable petechiae or purpura that evolve from red to brown that last from 3-10 days
usually found on dependent areas
Renal involvement in HSP is seen in __%
25-50%
Odynophagia vs. dysphagia
Odynophagia - pain during swallowing
Dysphagia - difficulty swallowing
Most common type of TEF (Nelsons)
Type A (EA and distal fistula)
For Robbins, Type B
50% of those who have TEF have associated syndrome of anomalies called
VATER/VACTERL
Vertebral, anorectal, trachea, esophagus, cardiac, renal, radial limb syndrome
Most common esophageal disorder in children of all ages
GERD
Major mechanism of GERD
Transient LES Relaxation
Main stimulus for transient relaxation of LES in GERD
Gastric distention
Surgical management for intractable GERD
Nissen Fundoplication
“gastric fundus (upper part) of the stomach is wrapped, or plicated, around the lower end of the esophagus and stitched in place, reinforcing the closing function of the lower esophageal sphincter”
Most common esophageal foreign body in 6 months to 3 years old
COINS
What is the management in cases of asymptomatic esophageal foreign bodies (blunt objects)?
May be observed up to 24 hrs in anticipation of passage in the stomach.
Indication for urgent endoscopy in esophageal foreign bodies
Sharp objects
Failure to visualize+symptomatic patient
True or False. Absent oral lesions mean that there is no significant esophagogastric injury.
False.
Liquid alkali in caustic ingestion causes what type of necrosis?
Liquefaction necrosis
Most common cause of non-bilous vomiting in children
Pyloric stenosis
Physical exam finding in pyloric stenosis
Firm, movable, olive shaped mass
Ultrasound findings in pyloric stenosis
pyloric thickness >4mm or length >14mm
Barium enema signs in pyloric stenosis
shoulder sign- bulge of the pyloric muscle in the antrum
double tract sign - streaks of barium in the narrowed channel
Atresia vs. Stenosis
Atresia - complete obstruction
Stenosis - partial block of luminal contents
Triad of Volvulus
S-I-R Volvulus
- Sudden onset severe epigastric pain
- Inability to pass tube in the stomach
- retching with emesis
X ray findings in volvulus
Bird’s beak sign
Inverted U sign
Coffee bean sign (midline crease corresponding to mesenteric root)
Management of volvulus
Decompression and derotation using a rectal tube or colonsocope if with no signs of bowel ischemia or perforation.
Lap derotation +/- bowel resection
48 hr old boy at 34 weeks AOG noted to vomit greenish material after feeding. PE revealed non-distended abdomen with hyperactive bowel sounds. Diagnosis?
Duodenal atresia
Incomplete rotation of the intestine during fetal development
Malrotation
Most common type of malrotation
failure of the cecum to move into the RLQ
Diagnostic and sign seen in duodenal atresia
Xray abdomen
Double bubble sign
Remnant of the omphalomesenteric duct which connects the yolk sac to the gut in the embryo and provides nutrition
Meckel Diverticulum
Most frequent GI congenital anomaly
Meckel Diverticulum
Most common cause of lower GI obstruction in neonates
Hirschprung’s Disease
Pathophysio of Hirschprung’s
arrest of neuroblast migration from proximal to distal bowel
absence of ganglion cells in the bowel wall beginning in the internal anal sphincter
The Currarino syndrome (also Currarino triad) is
iInherited congenital disorder where
(1) the sacrum (the fused vertebrae forming the back of the pelvis) is not formed properly,
(2) there is a mass in the presacral space in front of the sacrum, and
(3) there are malformations of the anus or rectum.
It can also cause an anterior meningocele or a presacral teratoma.
Diagnostic of choice for Hirschprung’s
Rectal suction biopsy
Portion of the alimentary tract is telescoped into an adjacent segment
Intussusception
Most common cause of intestinal obstruction between 3 months to 6 years old
Intussusception
Most common risk factors in intussusception
Rotavirus vaccine after 8 mos, adenovirus
Intussusception happens usually in what segments?
Ileocolic and Ileoileocolic
Characteristic of stool in intussusception
Currant Jelly Stools
Abdominal PE findings of intussusception
sausage-sahped mass in the RUQ which may increase in size and firmness during paroxysms of pain
Imaging findings in intussusception?
Xray, Barium enema, ultrasound
Xray - increased density
Barium enema - coiled spring pattern
Ultrasound - tubular mass, donut shaped, or target sign
Diagnostic of choice of peptic ulcer disease
Endoscopy
Test done to determine the presence of H. pylori
Rapid urease test
Treatment of H. pylori
PPI + Clarithromycin + Amox/Metronidazole
Definition of diarrhea
> 3 episodes in 24 hours
2 types of acute infectious diarrhea
Inflammatory and Non-inflammatory
Mechanisms of diarrhea
Secretory Osmotic Reduction in surface area Alteration in motility Mutations in apical membrane transport proteins
Fluid deficit in SOME Dehydration
50-100ml/kg
Parameters to classify a patient with some signs of dehydration
General condition: iriitable Eyes: Sunken Thirst: Thirsty, drinks eagerly Skin turgor: slow Weight loss %: 5-10% Fluid deficit: 50-100ml/kg
Treatment for patients with no signs of dehydration
give ORS after every loose stool
Treatment for patients with some dehydration
75ml/kg ORS over 4 hrs
Treatment for patients with severe dehydration
give a total of 100cc/kg pLR IV
- first 30cc/kg over 1 hr for infants, 30 mins for children
- next 70cc/kg over 5 hrs for infants, 2.5 hrs in children
Chronic or persistent diarrhea definition
> 14 days duration
Reduced osmolarity ORS components and total osmolarity
Glucose 75 Na 75 Cl 65 K 20 Citrate 10 TOTAL OSMOLARITY 245
Cornerstone in the management of AGE
Management of dehydration
Give the causative organism of AGE:
Presentation: watery diarrhea 7-10days
Treatment: supportive
Rotavirus
Give the causative organism of AGE:
Presentation: from nurseries and daycare
Treatment: TMP-SMZ
Enteropathogenic E. coli
Give the causative organism of AGE:
Presentation: hemorrhagic colitis HUS
Treatment: TMP-SMZ
EHEC
Give the causative organism of AGE:
Presentation: eggs milk and poultry
Treatment: ?
Salmonella
Treatment: treat only if <3mos old
Give the causative organism of AGE:
Presentation: person to person contact through contaminated food
Treatment: Cefixime, Erythromycin
Shigella and Campylobacter
Give the causative organism of AGE:
Presentation: Hx of antibiotic use
Treatment: ?
C. difficile
Metronidazole or Vancomycin
Give the causative organism of AGE:
Presentation: within 12 hours due to a preformed toxin with a common food source
Treatment: ?
S. aureus
no treatment
Give the causative organism of AGE:
Presentation: infects the colon, acute bloody diarrhea
Treatment: ?
E. histolytica
Metronidazole
Give the causative organism of AGE:
Presentation: cysts are ingested from contaminated food and water; watery diarrhea
Treatment: ?
G. lamblia
Metronidazole
Give the causative organism of AGE:
Presentation: profuse watery diarrhea; rice water consistency of stool with fishy odor; Washer woman’s hands
Treatment: ?
Cholera
Tetracycline
Amylase and lipase levels in acute pancreatitis (days elevated)
Serum amylase- elevated up to 4 days
Serum lipase - rises by 4-8 hrs, peaks at 24-48 hrs, elevated 8-14 days longer than amylase
Criteria for acute pancreatitis used in adults
Ranson’s criteria and APACHE
not suitable for children
In EINC, the significance of delayed cord clamping is to
decrease the incidence of anemia
Series of time bound chronologically-ordered standard procedures that the baby receives after birth
Essential Newborn Care
Most important component of the APGAR
Pulse
The best description of the APGAR Score is that it
assesses neonates in need of resuscitation
5 min - initial resuscitation
Components of newborn screening
CH CAH Galactosemia Phenylketonuria G6PD
Cheese like material that covers the normal term infant in varying amounts
Vernix caseosa
purplish reticulated pattern noted on the neonate when exposed to cold
cutis marmorata
Newborn PE: small white occasionally vesicopustular papules on an erythematous base develop after 1-3 days. Contains eosinophils
erythema toxicum
Newborn PE: vesiculopustular eruption over a dark macular base around the chin, neck, back, and soles, contains PMNs
pustular melanosis
Newborn PE: cysts appearing on the hard palate composed of accumulations of epithelial cells
Epstein pearls
Newborn PE: pearly white papules mostly seen on the chins and around the cheeks
Milia
Term infant with severe respiratory distress and a scaphoid abdomen on PE. Diagnosis?
Congenital diaphragmatic hernia
Most common type of congenital diaphragmatic hernia
Bochdalek
Term infant born with extrusion of abdominal viscera. Initial management?
Decompression and wrapping
Which is associated with more congenital anomalies? Omphalocoele or gastroschisis?
Omphalocoele
Gastroschisis is common on which side of the umbilicus
Right side
A preterm baby won’t stop crying. Baby has abdominal distention with abdominal erythema. Baby cries more when touched. Diagnosis?
Necrotizing enterocolitis
Xray of a newborn showed thickened bowel walls and air in the bowel wall. This is called? Intervention?
pneumatosis intestinale
supportive - hydrate and antibiotics
On CXR of a newborn, findings of “bubbly lungs” (cystic lucencies) with irreular denses strands and aearation. Diagnosis?
Bronchopulmonary dysplasia
CXR differences between TTN and RDS
RDS or HMD: finely granular lungs, ground glass appearance, air bronchograms, air filled esophagus
TTN: prominent pulmonary vacular markings
fluid lines in fissure, overaeration
On CXR of a newborn, coarse streaking granular pattern on both lungs is usually suggestive of what?
Meconium aspiration syndrome
Most common cause of jaundice in neonates?
Physiologic
Most serious complication of hyperbilirubinemia in newborns
Kernicterus
Amount of serum bilirubin on physiologic vs pathologic jaundice
Physiologic: peaks at 5-6mg/dl on 2-4 days
Pathologic: rate is rising faster than 5mg/dl/24hrs
Chart used for fast assessment of Jaundice?
Kramer’s chart
Fast serum bilirubin levels based on Kramer’s chart
head 6-8mg/dl
chest 9-12mg/dl
abdomen 12-14mg/dl
whole body >18 mg/dl
Most likely etiology of jaundice in the first 24 hrs.
Key clue: first born child
ABO incompatibility
Most likely etiology of jaundice in the first 24 hrs.
Key clue: second born child
Rh incompatibility
Most likely etiology of jaundice in the first 24 hrs.
Key clue: history of prolonged second stage of labor, no prenatal check up
Sepsis
Most likely etiology of jaundice in the first 24 hrs.
Key clue: history of maternal infection during pregnancy
TORCH infection
Most likely etiology of jaundice after the first 24 hrs.
Onset of jaundice: 2-3 days
Key clue: baby otherwise normal
Physiologic
Most likely etiology of jaundice after the first 24 hrs.
Onset of jaundice: 3-4 days
Key clue: mother supplements breastfeeding with sugar water
Breastfeeding jaundice
Most likely etiology of jaundice after the first 24 hrs.
Onset of jaundice: >1 week
Key clue: baby purely breastfed
breastmilk jaundice
Breastmilk versus breastfeeding jaundice?
Breastfeeding jaundice - “lack of breastfeeding jaundice,” is caused by insufficient breast milk intake resulting in inadequate quantities of bowel movements to remove bilirubin from the body.
This can usually be ameliorated by frequent breastfeeding sessions of sufficient duration to stimulate adequate milk production.
Breastmilk jaundice - breast milk jaundice is a biochemical occurrence and due to a lot of factors, there is inefficiency in bilirubin removal by gut bacteria or liver enzymes.
Staining in kernicterus usually occurs in the
basal ganglia and brainstem
Kernicterus is rare in infants with serum levels that are ___?
below 25mg/dl
Phases of kernicterus
Phase 1 - poor sucking, stupor, hypotonia
Phase 2 - hypertonia, opisthotonus, fever
Phase 3 - hypertonia
The most important risk factor that predisposes a neonate to sepsis
Prematurity
TORCH infection in the newly born.
Case. An IUGR baby born to a mother with history of infection during pregnancy
Key clue: vesicular lesions on the face and mouth
HSV
TORCH infection in the newly born.
Case. An IUGR baby born to a mother with history of infection during pregnancy
Key clue: Purpuric hemorrhagic lesions all over the body
rubella
TORCH infection in the newly born.
Case. An IUGR baby born to a mother with history of infection during pregnancy
Key clue: maculopapular rash, periostitis of the bone
syphilis
TORCH infection in the newly born.
Case. An IUGR baby born to a mother with history of infection during pregnancy
Key clue: chorioretinitis, periventricular calcifications
CMV
TORCH infection in the newly born.
Case. An IUGR baby born to a mother with history of infection during pregnancy
Key clue: chorioretinitis, microcephaly, hepatosplenomegaly, imaging: intracerebral calcifications
Toxoplasmosis
TORCH infection in the newly born.
Case. An IUGR baby born to a mother with history of infection during pregnancy
Key clue: cutaneous scars, cortical atrophy
Varicella
Colostrum is produced over the first few days of lactation. This is rich in what immunoglobulin?
IgA
Whey to casein ratio of mature human milk?
3:2