Pearls_12 Flashcards

1
Q

Associations:

Anti-Smooth Muscle

A

Auto-immune Hepatitis

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2
Q

Associations:

Anti-U1 -RNP

A

Mixed Connective Tissue Disorder

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3
Q

Associations:

Anti-Jo1

A

Polymyositis and Dermatomyositis

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4
Q

Anti-Mitochondrial

A

Primary Biliary Cirrhosis

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5
Q

Anti- SSA (Anti-Ro) and Anti-SSB (Anti-La)

A

Sjogren’s Syndrome (associated with congenital heart block in baby - if these are positive in mama and can also be positive in Lupus)

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6
Q

Anti-Centromere

  • name dx
  • assoc with what type of HTN –> therefore, screen with what cardiographic and diagnose it with what procedure?
A

CREST (Limited (as opposed to systemic) Scleroderma) -> associated with Pulm HTN so screen with ECHO and diagnose with right heart cath

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7
Q

Anti-Topoisomerase (same as Anti-Scl70)

  • Dx?
  • assoc with? –> so screen with? Dx with what modality?
A

Systemic (as opposed to limited) Scleroderma -> assoc with Pulmonary Fibrosis so screen with PFTs and diagnose with high res CT chest

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8
Q

Anti-Histone

  • Dx?
  • name the drugs that cause it?
A

Drug Induced Lupus (assoc with Hydralazine, INH, Procainamide, Etanercept, Inflixamab, Minoxadil)

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9
Q

Anti-CCP

A

Rheumatoid Arthritis (more specific than RF)

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10
Q

Anti-Smith and Anti-dsDNA

  • Dx?
  • which one is more specific?
  • which one is assoc with degree of renal involvment?
A

Lupus (Smith is more specific and dsDNA is assoc with degree of renal involvement)

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11
Q

C-ANCA (aka Anti-proteinase 3)

A

Wegners (aka Granulomatosis with Polyangiitis)

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12
Q

P-ANCA (aka Anti-myeloperoxidase)

- name two dx it’s assoc with?

A

Churg Strauss (aka Eosinophilic Granulomatosis with Polyangiitis) and Microscopic Polyangiitis and Ulcerative Colitis

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13
Q

Auto-immune Hepatitis has what diagnostic marker?

A

Anti-Smooth Muscle

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14
Q

Name the dx marker for the following:

Mixed Connective Tissue Disorder

A

Anti-U1-RNP

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15
Q

Name the dx marker for the following:

Polymyositis and dermatomyositis

A

Anti-Jo1

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16
Q

Name the dx marker for the following:

Primary Biliary Cirrhosis

A

Anti-Mt

17
Q

Name the dx marker for the following:

Sjogren’s Syndrome

A

Anti-SSA (Anti-Ro)

Anti-SSB (Anti-La)

18
Q

Name the dx marker for the following:

CREST (Limited Scleroderma)

A

Anti-Centromere

19
Q

Pulm HTN is assoc with what type of scleroderma?

  • screen it with ___
  • dx with ___
A

CREST (limited scleroderma)

  • screen with ECHO
  • dx with RHC
20
Q

Name the dx marker for the following:

Systemic Scleroderma

A

Anti-Topoisomerase (same as Anti-Scl70)

21
Q

Pulm fibrosis is assoc with what type of scleroderma?

  • screen with?
  • dx with?
A

systemic scleroderma

  • screen with PFTs
  • dx with high res CT chest
22
Q

hint for the following: both are assoc with pulm problems

Limited scleroderma (CREST) assoc with what problem?

Systemic scleroderma assoc with what problem?

A

limited
- pulm htn

systemic
- pulm fibrosis

23
Q

Name the dx marker for the following:

Drug induced lupus

A

anti-histone

24
Q

Name the dx marker for the following:

RA
- name two markers and which is more specific?

A

Anti-CCP (more sp)

RF

25
Q

Name the dx marker for the following:

Lupus
- name two and which is more specific

A

Anti-smith (more sp)

Anti-dsDNA

26
Q

Name the dx marker for the following:

Wegners (aka granulomatosis with polyangitis)
- and name the other name that the marker is aka

A

C-ANCA

aka Anti-proteinase 3

27
Q

Name the dx marker for the following:

Churg Strauss (aka eosinophilic Granulomatosis polyangitis)

A

P-ANCA

aka anti-myeloperoxidase

28
Q

Name the dx marker for the following:

Microscopic polyangitis

A

P-ANCA

aka anti-myeloperoxidase

29
Q

Name the dx marker for the following:

UC

A

P-ANCA

aka anti-myeloperoxidase

30
Q

Name the dx marker for the following three dx (each has the same marker):

Churg Strauss (aka Eosinophilic Granulomatosis with Polyangiitis)

Microscopic Polyangiitis

Ulcerative Colitis

A

P-ANCA

aka anti-myeloperoxidase