Peads oncology presentation Flashcards
Most common paediatric malignancies?
leukaemia’s
CNS
lymphoma
soft tissue sarcoma
When does a wills tumor present?
<1 yo
what brain malignancy present specifically in <3 yo?
ependymoma
choroid plexus Ca
What brain malignancy covers age groups 0-22?
medulla plastoma
Astrocytoma
cerebellar astro.
What dd for head back cancer?
NB
RMS
lymphoma
What predisposition syndrome cause cancer in kids?
Retinoblastoma Li-fraumeni NF 1/2 AT FA
What dx for horners syndrome?
NB
What dx for SVC obstruction
NHL
What dx for proptosis?
NB and RMS
What dx fora pathological fracture?
Osteosarcoma
Ewigs sarcoma
What dx for rashes
Hodkins
LCH - langerhans cell histiocytosis
What dx for night sweats?
lymphomas
What paediatric tumours cause hepatomegaly?
leukaemia
NB
Hepatoblastoma
mets
What paediatric tumours cause splenomegaly?
leukaemia
MDS
Rule of thumb… which signifies cancer, speno- or hepatospenomegaly?
Splenomegaly indicates tumour
What peadiatric tumours cause pelvic tumour
Rhabdos
Ovarian - teratoma, GC
sacrococcygeal teratomas
What Sx of infra-tectorial tumours?
CN palsies = brainstem CN VI (flash localising, failure = brainstemm) Ataxia and co-ordination
What Sx of supra-tectorial tumours?
Raised ICP seizure UMN signs visual field defects diencephalic syndrome (hypothalamus)
Ddx x-ray limb.
Osteomsarcoma
Ewings
Langerhan’s cell histiocytosis
Spot diagnosis: punched out lesions in skull?
Langerhan’s cell histiocytosis
Investigations of bone marrow aspirate shows dx of…
NB
RMS
lymphoma
Investigations of LP aspirate shows dx of…
lymphoma
some bone tumours
What can a MIBG scan help detect?
NB
What can a urinary catecholamines help detect?
NB phaeos
What are negative prognostic markers?
MCYN copy number
1p deletion
Gain of 17q
What ChT affects lung function?
bleomycin
Which tumours have a roll for ChT in delaying radiotherapy?
medulloblastoma
GCT
gliomas
Why is asparaginase used in ALL?
depletes asparagine, which lymphoma cannot synthesis, therefore limiting growth.
What function of age affects the prognosis of NB?
<1 yo - good survival
>2yo - poor survival