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Troll Toll or Lee Fee? > PCQ Stanley > Flashcards

PCQ Stanley Flashcards

1
Q

In the absence of accessory proteins, cytoskeletal filament lengthening occurs by:

A
  • the addition of subunits at filament ends and shortening occurs by .
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2
Q

In the absence of accessory proteins, cytoskeletal filament shortening occurs by:

A
  • the dissociation of subunits from cytoskeletal filament ends
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3
Q

“Cytoskeletal filaments can grow and shrink, and in the case of actin filaments and microtubules, these dynamics can depend on:”

A
  • actin or tubulin binding proteins
  • the breakage and formation of noncovalent interactions between subunits
  • the hydrolysis of the nucleotide bound by filament subunits
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4
Q

What is required for microtubule formation in the cell, but not required in cell-free, in vitro microtubule assembly reactions?

A

the gamma tubulin ring complex

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5
Q

For an actin filament to form in vitro, which of the following is the best answer for what must first be present?

  • actin monomers in a GDP bound state
  • the gamma tubulin ring complex
  • isolated actin monomers
  • an aggregate of several subunits
A

-an aggregate of several subunits

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6
Q

three major cytoskeletal filaments

A
  • actin filament
  • microtubule filament
  • intermediate filament
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7
Q

Which of the three major cytoskeletal filaments corresponds to this statement:

“subunit that composes this filament binds ATP”

A

actin filament

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8
Q

Which of the three major cytoskeletal filaments corresponds to this statement:

“subunit that composes this filament binds GTP”

A

microtubule filament

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9
Q

Which of the three major cytoskeletal filaments corresponds to this statement:

“subunit that composes this filament is a heterodimer”

A

microtubule filament

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10
Q

Which of the three major cytoskeletal filaments corresponds to this statement:

“unlike the other two, this filament is symmetrical and not polarized”

A

-intermediate filament

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11
Q

Which of the three major cytoskeletal filaments corresponds to this statement:

“responsible for whole cell movements”

A

actin filament

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12
Q

Which of the three major cytoskeletal filaments corresponds to this statement:

“forms the contractile ring at the end of cell division”

A

actin filament

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13
Q

Which of the three major cytoskeletal filaments corresponds to this statement:

“forms the mitotic spindle for chromosome segregation during mitosis”

A

microtubule filament

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14
Q

Which of the three major cytoskeletal filaments corresponds to this statement:

“helps organelles to be positioned properly within the cell”

A

microtubule filament

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15
Q

Which of the three major cytoskeletal filaments corresponds to this statement:

“subunit binds ATP to phosphorylate another protein”

A

None

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16
Q

Where does a microtubule from the mitotic spindle make stable contact with a replicated (mitotic) chromosome?

A

at the kinetochore

17
Q

Replicated (mitotic) chromosomes each consist of two sister chromatids which are associated through a protein complex called cohesin. What does a single sister chromatid contain?

A

one dsDNA molecule

18
Q

Match the following processes to the phase in the animal cell cycle when they occur.

“Centrosome duplication”

A

S phase

19
Q

Match the following processes to the phase in the animal cell cycle when they occur.

“DNA replication”

A

S phase

20
Q

Match the following processes to the phase in the animal cell cycle when they occur.

“Chromosome segregation”

A

M phase

21
Q

Match the following processes to the phase in the animal cell cycle when they occur.

“Division of the cytoplasm through cytokinesis”

A

M phase

22
Q

Match the following processes to the phase in the animal cell cycle when they occur.

“Cell growth”

A

G1 & G2

23
Q

Match the following processes to the phase in the animal cell cycle when they occur.

“Determination of whether conditions are favorable for continued growth and division”

A

G1 & G2

24
Q

Match the following processes to the phase in the animal cell cycle when they occur.

“Mitosis”

A

M phase

25
Q

Select each of the following that is or describes an actin motor protein:

  • Dynein
  • kinesin
  • moves towards plus end of a cytoskeletal filament
  • binds and hydrolyzes GTP
  • moves towards minus end of a cytoskeletal filament
  • binds and hydrolyzes ATP
  • myosin
A
  • moves towards plus end of a cytoskeletal filament
  • binds and hydrolyzes ATP
  • myosin
26
Q

Select each of the following that is or describes a microtubule motor protein:

  • Dynein
  • kinesin
  • moves towards plus end of a cytoskeletal filament
  • binds and hydrolyzes GTP
  • moves towards minus end of a cytoskeletal filament
  • binds and hydrolyzes ATP
  • myosin
A
  • Dynein
  • kinesin
  • moves towards plus end of a cytoskeletal filament
  • moves towards minus end of a cytoskeletal filament
  • binds and hydrolyzes ATP
27
Q

What is required before sister chromatids can separate and the cell transitions from metaphase into anaphase?

A
  • the cleavage of a cohesin subunit
  • the attachment of kinetochores to the spindle
  • the biorientation of the replicated chromosome
28
Q

Which of the following underlies regulation of Cdks at different stages of the cell cycle?

  • Transcription of cyclin genes
  • Degradation of cyclin proteins
  • Transcription of Cdk genes
  • Degradation of Cdk proteins
  • Binding by Cdk inhibitor proteins
  • Phosphorylation of Cdk proteins
A
  • Transcription of cyclin genes
  • Degradation of cyclin proteins
  • Binding by Cdk inhibitor proteins
  • Phosphorylation of Cdk proteins
29
Q

In Dr. Lippincott-Schwartz’s experiment using a photoactivatable version of VSVG (a secreted protein) fused to GFP, she was able to monitor the movement of VSVG:

A

through the Golgi out to the plasma membrane

30
Q

For monitoring the movement of a protein through the secretory system, which of the following makes using photoactivatable GFP a preferable approach over regular GFP?

  • makes only a fraction of the molecules of a particular protein visible, which can then be followed over time
  • using photoactivatable GFP is less hazardous
  • can visualize the localization of a protein in living cells
A

-makes only a fraction of the molecules of a particular protein visible, which can then be followed over time

31
Q

Select all answers that accurately describe membranes.

  • heterogeneous, with distinct clusters of particular phospholipids and membrane proteins
  • proteins and lipids can move freely, often exchanging between monolayers
  • proteins and lipids can move freely in a lateral direction, within a monolayer
  • well mixed, with a random distribution of phospholipid types, cholesterol, and membrane proteins
A
  • heterogeneous, with distinct clusters of particular phospholipids and membrane proteins
  • proteins and lipids can move freely in a lateral direction, within a monolayer
32
Q

Match the vesicle origin/destination with its coat protein type.

ER/Golgi

A

COP II

33
Q

Match the vesicle origin/destination with its coat protein type.

Golgi/ER

A

COP I

34
Q

Match the vesicle origin/destination with its coat protein type.

Plasma membrane/endosome

A

Clatherin

35
Q

What can facilitate vesicle coat protein binding to begin vesicle budding?

A
  • association of GTPases with the donor membrane

- the particular phosphorylation pattern on the head groups of phosphatidylinositol

36
Q

What is the correct order of events that leads to vesicle fusion in cells?

A

Tethering, docking, fusion

37
Q

Which of the following describe Rab effectors?

  • interact with Rab
  • cytoskeletal motor proteins
  • vesicle tethering proteins
  • are only transmembrane proteins
A
  • interact with Rab
  • cytoskeletal motor proteins
  • vesicle tethering proteins
38
Q

Which of the following cycles between being cytosolic and membrane-associated?

  • PI 3-kinase
  • v-SNAREs
  • Rab proteins
  • NSF
  • t-SNAREs
A
  • PI 3-kinase
  • Rab proteins
  • NSF

Troll Toll or Lee Fee? (1 decks)

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