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Pharmacology Exam 3 > PCOL Exam 3 Drug Classes > Flashcards

PCOL Exam 3 Drug Classes Flashcards

1
Q

Hydralazine

A

Direct vasodilator

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2
Q

BiDil

A

Direct vasodilator

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3
Q

minoxidil

A

Direct vasodilator

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4
Q

diazoxide

A

Direct vasodilator

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5
Q

Natrecor

A

Brain Natriuretic Peptide

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6
Q

Neprilysin inhibitor: Sacubitril (Sacubritril + valsartan = Entresto)

A

Brain Natriuretic Peptide

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7
Q

Nitroglycerin

A

Organic Nitrates (Nitrosovasodilators)

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8
Q

Isosorbide dinitrate

A

Organic Nitrates (Nitrosovasodilators)

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9
Q

Isosorbide - 5- mononitrate

A

Organic Nitrates (Nitrosovasodilators)

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10
Q

Nitroprusside (SNP)

A

Nitrosovasodilators

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11
Q

Ranolazine

A

Drug Directly affecting Cardiac Currents

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12
Q

sildenafil

A

PDE-5 inhibitors (Vasodilators for Erectile Dysfunction and Pulmonary Artery Hypertension)

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13
Q

tadalafil

A

PDE-5 inhibitors (Vasodilators for Erectile Dysfunction)

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14
Q

vardenafil

A

PDE-5 inhibitors (Vasodilators for Erectile Dysfunction)

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15
Q

Avanafil

A

PDE-5 inhibitors (Vasodilators for Erectile Dysfunction)

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16
Q

Alprostadil

A

PGE analog (Vasodilators for Erectile Dysfunction)

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17
Q

Dinoprostone

A

PGE 2 analog (Prostaglandin-based drugs)

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18
Q

dinoprost

A

PGF 2a analog (Prostaglandin-based drugs)

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19
Q

carboprost

A

PGF 2a analog (Prostaglandin-based drugs)

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20
Q

bimatoprost

A

PGF 2a analog (Prostaglandin-based drugs)

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21
Q

latanoprost

A

PGF 2a analog (Prostaglandin-based drugs)

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22
Q

tafluprost

A

PGF 2a analog (Prostaglandin-based drugs)

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23
Q

travoprost

A

PGF 2a analog (Prostaglandin-based drugs)

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24
Q

Nitric Oxide

A

Vasodilators for Pulmonary Artery Hypertension

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25
Q

Epoprostenol

A

Prostacyclin analogs (Vasodilators for Pulmonary Artery Hypertension)

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26
Q

iloprost

A

Prostacyclin analogs (Vasodilators for Pulmonary Artery Hypertension)

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27
Q

treprostinil

A

Prostacyclin analogs (Vasodilators for Pulmonary Artery Hypertension)

28
Q

selexipag

A

Prostacyclin analogs (Vasodilators for Pulmonary Artery Hypertension)

29
Q

bosentan

A

Endothelin receptor antagonist (Vasodilators for Pulmonary Artery Hypertension)

30
Q

macitentan

A

Endothelin receptor antagonist (Vasodilators for Pulmonary Artery Hypertension)

31
Q

ambrisentan

A

Endothelin receptor antagonist (Vasodilators for Pulmonary Artery Hypertension)

32
Q

Riociguat

A

Soluble guanylate cyclase stimulant (Vasodilators for Pulmonary Artery Hypertension)

33
Q

Nifedipine

A

Gen 1 Dihydropyridines (DHPs Calcium Channel Blockers)

34
Q

Diltiazem

A

Gen 1 Non-Dihydropyridines (Non-DHPs Calcium Channel Blockers)

35
Q

Verapamil

A

Gen 1 Non-Dihydropyridines (Non-DHPs Calcium Channel Blockers)

36
Q

Nicardipine (IV)

A

Gen 1 Dihydropyridines (DHPs Calcium Channel Blockers)

37
Q

Isradipine

A

Gen 2 Dihydropyridines (DHPs Calcium Channel Blockers)

38
Q

Nimodipine (for cerebrovascular spasm)

A

Gen 2 Dihydropyridines (DHPs Calcium Channel Blockers)

39
Q

Nisoldipine

A

Gen 2 Dihydropyridines (DHPs Calcium Channel Blockers)

40
Q

Felodipine

A

Gen 2 Dihydropyridines (DHPs Calcium Channel Blockers)

41
Q

Clevidipine (IV)

A

Gen 3 Dihydropyridines (DHPs Calcium Channel Blockers)

42
Q

Amlodipine

A

Gen 3 Dihydropyridines (DHPs Calcium Channel Blockers)

43
Q

lercanidipine

A

Gen 4 Dihydropyridines (DHPs Calcium Channel Blockers)

44
Q

Lacidipine

A

Gen 4 Dihydropyridines (DHPs Calcium Channel Blockers)

45
Q

Aliskiren

A

Direct Renin Inhibitors (DRIs RAAS inhibitor of angiotensinogen t angiotensin 1)

46
Q

Benazepril

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) Inactive ester prodrugs, converted to active
metabolites (‘prilat’) by the liver
Administered orally
Eliminated via kidneys

47
Q

moexipril

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) Inactive ester prodrugs, converted to active
metabolites (‘prilat’) by the liver
Administered orally
Eliminated via kidneys

48
Q

Perindopril

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) Inactive ester prodrugs, converted to active
metabolites (‘prilat’) by the liver
Administered orally
Eliminated via kidneys

49
Q

ramipril

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) Inactive ester prodrugs, converted to active
metabolites (‘prilat’) by the liver
Administered orally
Eliminated via kidneys

50
Q

Trandolapril

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) Inactive ester prodrugs, converted to active
metabolites (‘prilat’) by the liver
Administered orally
Eliminated via kidneys

51
Q

Enalapril

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) Inactive ester prodrugs, converted to active
metabolites (‘prilat’) by the liver
Administered orally
Eliminated via kidneys

52
Q

Enalaprilat

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) Active as is, *administered IV

53
Q

Captopril

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) Active drug, active metabolite

54
Q

Lisinopril

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) Active drug, excreted unchanged

55
Q

Fosinopril

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) *Eliminated via bile

56
Q

Quinapril

A

Angiotensin-Converting Enzyme Inhibitors of converting Angiotensin I to angiotensin II) *Eliminated via bile

57
Q

Adverse effects of ACEIs

A

cough, angioedema, Hyperkalemia
Acute kidney injury, First-dose hypotension and postural hypotension, Teratogenic potential

58
Q

Candesartan & Olmesartan

A

Angiotensin II Receptor Blockers
(Inactive ester prodrugs, given orally, renal and biliary excretion)

59
Q

Irbesartan & Eprosartan

A

Angiotensin II Receptor Blockers

60
Q

*Telmisartan (Micardis) &
Valsartan (Diovan)

A

Angiotensin II Receptor Blockers
(Can cross BBB, can be used in stroke)

61
Q

*Losartan (Cozaar)

A

Angiotensin II Receptor Blockers
(Active prodrug, converted to more active
metabolite by CYP2C9 and CYP3A4*)

62
Q

Clinical Uses of RAAS Modulators

A

1.Hypertension
2. Heart failure/after myocardial infarction
3. Diabetic nephropathy/acute renal failure/chronic kidney disease

63
Q

Drug interactions/combinations

A
  • Other antihypertensive drug classes
  • Potassium supplements/potassium-sparing diuretics
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
64
Q

Contraindications for RAAS Modulators

A
  • Bilateral renal artery stenosis
  • Angioedema associated with previous use
  • Pregnancy
65
Q

ACEIs vs ARBs

A

Can ACEIs block Ang II
production completely?
Q: Do ARBs block AT2
receptors?
Q: Do ARBs increase AT2
receptor activation?

66
Q
A

Pharmacology Exam 3 (1 decks)

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