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PCOL 406 > PCOL 406 Exam 2 > Flashcards

PCOL 406 Exam 2 Flashcards

1
Q

Nonselective a-blockers meds

A

phenoxybenzamine

phentolamine

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2
Q

Selective a1-blockers meds

A

doxazosin
tamsulosin
alfuzosin
silodosin

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3
Q

Nonselective B-blockers meds

A

propranolol
timolol
pindolol

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4
Q

Selective B1-blockers meds

A

atenolol
esmolol
metoprolol

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5
Q

a- and B- Adrenoceptor Antagonists

A

carvedilol

labetalol

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6
Q

Alfuzosin, tamsulosin mechanism of action

A

competitive a1-blocker

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7
Q

Alfuzosin, tamsulosin pharmacological effects

A

relax bladder, urethral and prostate smooth muscle

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8
Q

Alfuzosin, tamsulosin clinical use

A

urinary symptoms caused by benign prostatic hyperplasia

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9
Q

Doxazosin, prazosin, terazosin mechanism of action

A

competitive a1-blocker

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10
Q

Doxazosin, prazosin, terazosin pharmacological effects

A
  • causes vasodilation and decreases blood pressure

- relax bladder, urethral, and prostate smooth muscle

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11
Q

Doxazosin, prazosin, terazosin clinical use

A
  • hypertension

- urinary symptoms cause by benign prostatic hyperplasia

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12
Q

Phenoxybenzamine mechanism of action

A

noncompetitive a1- and a2- blocker

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13
Q

Phenoxybenzamine pharmacological effect

A

causes vasodilation and decreases blood pressure

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14
Q

Phenoxybenzamine clinical use

A

hypertension in pheochromocytoma

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15
Q

Phentolamine mechanism of action

A

competitive a1- and a2- blocker

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16
Q

Phentolamine pharmacological effect

A
  • causes vasodilation

- decreases vascular resistance and blood pressure

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17
Q

Phentolamine clinical use

A
  • hypertension in pheochromocytoma

- treat necrosis and ischemia after injection of an a-adrenoceptor agonist

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18
Q

Acebutolol mechanism of action

A

B1-blocker with ISA and MSA

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19
Q

Acebutolol pharmacological effect

A

decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure

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20
Q

Acebutolol clinical use

A
  • hypertension

- cardiac dysrhythmias

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21
Q

Atenolol mechanism of action

A

B1-blocker

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22
Q

Atenolol pharmacological effect

A

decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure

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23
Q

Atenolol clinical use

A
  • hypertension
  • angina pectoris
  • acute myocardial infarction
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24
Q

Betaxolol mechanism of action

A

B1-blocker

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25
Q

Betaxolol pharmacological effect

A
  • decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure
  • decreases intraocular pressure
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26
Q

Betaxolol clinical use

A

glaucoma

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27
Q

Bisoprolol mechanism of action

A

B1-blocker

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28
Q

Bisoprolol pharmacological effect

A

decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure

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29
Q

Bisoprolol clinical use

A

hypertension

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30
Q

Esmolol mechanism of action

A

B1-blocker

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31
Q

Esmolol pharmacological effect

A

decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure

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32
Q

Esmolol clinical use

A

acute supraventricular tachycardia and hypertension

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33
Q

Metoprolol mechanism of action

A

B1-blocker with MSA

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34
Q

Metoprolol pharmacological effect

A

decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure

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35
Q

Metoprolol clinical use

A
  • hypertension
  • angina pectoris
  • acute myocardial infarction
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36
Q

Nadolol mechanism of action

A

B1- and B2- blocker

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37
Q

Nadolol pharmacological effect

A

decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure

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38
Q

Nadolol clinical use

A
  • hypertension
  • angina pectoris
  • migraine headache
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39
Q

Nebivolol mechanism of action

A

B1-blocker

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40
Q

Nebivolol pharmacological effect

A

decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure

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41
Q

Nebivolol clinical use

A

hypertension

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42
Q

Pindolol mechanism of action

A

B1- and B2- blocker with ISA and MSA

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43
Q

Pindolol pharmacological effect

A

decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure

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44
Q

Pindolol clinical use

A

hypertension

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45
Q

Propranolol mechanism of action

A

B1- and B2- blocker with MSA

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46
Q

Propranolol pharmacological effect

A

decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure

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47
Q

Propranolol clinical use

A
  • hypertension
  • angina pectoris
  • cardiac dysrhythmias
  • hypertrophic subaortic stenosis
  • essential tremor
  • migraine headache
  • acute thyrotoxicosis
  • acute myocardial infarction
  • pheochromocytoma
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48
Q

Timolol mechanism of action

A

B1- and B2- blocker

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49
Q

Timolol pharmacological effect

A
  • decreases cardiac rate, output, O2 demand, AV node conduction, and blood pressure
  • decreases intraocular . pressure
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50
Q

Timolol clinical use

A
  • hypertension
  • acute myocardial infarction
  • migraine headache
  • glaucoma
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51
Q

Carvedilol mechanism of action

A

B1- and B2- blocker, a1-blocker

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52
Q

Carvedilol pharmacological effect

A
  • causes vasodilation
  • decreases heart rate and blood pressure in patients with hypertension
  • increases cardiac output in patients with heart failure
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53
Q

Carvedilol clinical use

A
  • hypertension

- heart failure

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54
Q

Labetalol mechanism of action

A

B1- and B2- blocker with MSA, a1-blocker

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55
Q

Labetalol pharmacological effect

A
  • causes vasodilation

- decreases heart rate and blood pressure

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56
Q

Labetalol clinical use

A

hypertension

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57
Q

Diuretics meds

A

thiazides

hydrochlorothiazide

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58
Q

Potassium Sparing Diuretics meds

A

amiloride

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59
Q

Sympatholytics adrenoceptor antagonist meds

A 
carvedilol
metoprolol
propranolol
atenolol 
doxazosin
metyrosine
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60
Q

Sympatholytics centrally acting drugs meds

A

clonidine

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61
Q

Angiotensin-converting enzyme (ACE) inhibitors meds

A

lisinopril
benazepril
enalapril

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62
Q

Angiotensin receptor antagonists meds

A

losartan
candesartan
irbesartan

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63
Q

Direct renin inhibitor meds

A

aliskiren

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64
Q

Vasodilators calcium channel blockers (CCBs) meds

A 
amlodipine
diltiazem 
nifedipine 
verapamil 
hydralazine
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65
Q

Vasodilators Dopamine agonist meds

A

fenoldopam

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66
Q

Primary Hypertension

A

cannot be attributed to a specific cause

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67
Q

Secondary Hypertension

A

results from an identifiable cause

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68
Q

Angiotensin II

A

may cause vascular injury by activating growth factors that cause vascular smooth muscle proliferation and hypertrophy as well as fibrotic changes in the vascular wall

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69
Q

Cardiac Output

A

product of stroke volume and heart rate, increased by sympathetic stimulation via activation of B1-adrenoceptors in the heart

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70
Q

PVR (Peripheral Vascular Resistance)

A

determined by the resistance to blood flow through the arterioles

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71
Q

Thiazide and loop diuretics common adverse effects

A
  • blood cell deficiencies
  • hyperlipidemia
  • hyperuricemia
  • hypokalemia
  • electrolyte changes
  • aggravation of diabetes
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72
Q

Thiazide and loop diuretics common drug interactons

A
  • increase serum levels of lithium
  • hypotensive effect decreased by NSAIDs
  • augmented by ACE inhibitors
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73
Q

Potassium sparing diuretics common adverse effects

A

hyperkalemia

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74
Q

Potassium sparing diuretics common drug interactions

A

hyperkalemic effect increased by ACE inhibitors and potassium supplements

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75
Q

a-adrenoceptor antagonists common adverse effects

A
  • dizziness
  • first dose syncope
  • fluid retention
  • orthostatic hypotension
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76
Q

a-adrenoceptor antagonists common drug interactions

A

hypotensive effect increased by B-adrenoceptor antagonists and diuretics

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77
Q

Clonidine common adverse effects

A
  • dry mouth
  • fatigue
  • rebound hypertension
  • sedation
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78
Q

Clonidine common drug interactions

A
  • hypotensive effect decreased by tricyclic antidepressants

- sedative effect increased by CNS depressants

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79
Q

B-adrenoceptor antagonists common adverse effects

A
  • bradycardia
  • bronchoconstriction
  • depression
  • fatigue
  • impaired glycogenolysis
  • vivid dreams
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80
Q

B-adrenoceptor antagonists common drug interactions

A
  • cardiac depression increased by diltiazem and verapamil

- hypotensive effect decreased by NSAIDs

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81
Q

Guanfacine common adverse effects

A
  • dry mouth
  • fatigue
  • rebound hypertension
  • sedation
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82
Q

Guanfacine common drug interactions

A
  • hypotensive effect decreased by tricyclic antidepressants

- sedative effect increased by CNS depressants

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83
Q

Methyldopa common adverse effects

A
  • autoimmune hemolytic anemia
  • hepatitis
  • lupus-like syndrome
  • dry mouth
  • fatigue
  • rebound hypertension
  • sedation
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84
Q

Methyldopa common drug interactions

A
  • hypotensive effect increased by levodopa
  • hypotensive effect decreased by tricyclic antidepressants
  • sedative effect increased by CNS depressants
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85
Q

ACE inhibitors common adverse effects

A
  • acute renal failure
  • angioedema
  • cough
  • hyperkalemia
  • metallic taste
  • neutropenia
  • rash
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86
Q

ACE inhibitors common drug interactions

A
  • increase serum levels of lithium
  • hyperkalemic effect increased by potassium-sparing diuretics and potassium supplements
  • hypotensive effect decreased by NSAIDs
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87
Q

Angiotensin receptor antagonists common adverse effects

A

hyperkalemia

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88
Q

Angiotensin receptor antagonists common drug interactions

A

serum levels of drug increased by cimetidine and decreased by phenobarbital

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89
Q

Aliskiren common adverse effects

A

hyperkalemia

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90
Q

Aliskiren common drug interactions

A
  • aliskiren reduces serum levels of furosemide

- cyclosporine increases levels of aliskiren

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91
Q

Dihydropyridine common adverse effects

A
  • dizziness
  • edema
  • gingival hyperplasia
  • headache
  • tachycardia
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92
Q

Dihydropyridine common drug interactions

A

serum levels of drug increased by azole antifungal agents, cimetidine, and grapefruit juice

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93
Q

Diltiazem common adverse effects

A
  • atrioventricular block
  • bradycardia
  • constipation
  • dizziness
  • edema
  • gingival hyperplasia
  • headache
  • heart failure
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94
Q

Diltiazem common drug interactions

A
  • increases serum levels of carbamazepine, digoxin, and theophylline
  • decreases serum levels of lithium
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95
Q

Verapamil common adverse effects

A
  • atrioventricular block
  • bradycardia
  • constipation
  • dizziness
  • edema
  • gingival hyperplasia
  • headache
  • heart failure
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96
Q

Verapamil common drug interactions

A
  • increases serum levels of carbamazepine, digoxin, and theophylline
  • decreases serum levels of lithium
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97
Q

Hydralazine common adverse effects

A
  • angina
  • dizziness
  • fluid retention
  • headache
  • lupus-like syndrome
  • tachycardia
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98
Q

Hydralazine common drug interactions

A

hypotensive effect decreased by NSAIDs

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99
Q

Minoxidil common adverse effects

A
  • angina
  • dizziness
  • fluid retention
  • headache
  • hypertrichosis
  • pericardial effusion
  • tachycardia
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100
Q

Minoxidil common drug interactions

A

hypotensive effect decreased by NSAIDs

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101
Q

Nitroprusside common adverse effects

A
  • dizziness
  • headache
  • increased intracranial pressure
  • methemoglobinemia
  • thiocyanate
  • cyanide toxicity
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102
Q

Nitroprusside common drug interactions

A

none

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103
Q

Fenoldopam common adverse effects

A
  • headache

- nausea

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104
Q

Fenoldopam common drug interactions

A

none

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105
Q

Age 65+ most preferred drugs

A

ARB, ACEI, CCB, thiazide diuretic

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106
Q

Age 65+ least preferred drugs

A

clonidine, B-blocker

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107
Q

African heritage most preferred drugs

A

thiazide diuretic, CCB

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108
Q

African heritage least preferred drugs

A

B-blocker

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109
Q

Pregnant most preferred drugs

A

methyldopa, labetalol

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110
Q

Pregnant least preferred drugs

A

ACEI, ARB, aliskiren

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111
Q

Angina Pectoris most preferred drugs

A

B-blocker, CCB

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112
Q

Angina Pectoris least preferred drugs

A

hydralazine, minoxidil

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113
Q

Myocardial infarction most preferred drugs

A

ACEI, ARB, B-blocker, aldosterone antagonist

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114
Q

Myocardial infarction least preferred drugs

A

hydralazine, minoxidil

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115
Q

Congestive heart failure most preferred drugs

A

ACEI, ARB, B-blocker, thiazide or loop diuretics

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116
Q

Congestive heart failure least preferred drugs

A

verapamil

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117
Q

Stroke prevention most preferred drugs

A

ARB, ACEI, CCB, thiazide diuretic

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118
Q

Kidney disease most preferred drugs

A

ACEI or ARB

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119
Q

Diabetes most preferred drugs

A

ACEI, ARC, CCB, thiazide diuretic

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120
Q

Asthma most preferred drugs

A

ACEI, ARC, CCB, thiazide diuretic

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121
Q

Benign prostatic hyperplasia most preferred drugs

A

a-blocker

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122
Q

Migraine headache most preferred drugs

A

B-blocker, CCB

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123
Q

Osteoporosis most preferred drugs

A

thiazide diuretic

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124
Q

Organic Nitrites and Nitrates meds

A

amyl nitrate
isosorbide dinitrate
isosorbide mononitrate
nitroglycerin

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125
Q

Calcium Channel Blockers meds

A

amlodipine
nifedipine
diltiazem
verapamil

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126
Q

B-Adrenoceptor Antagonists meds

A

atenolol
metoprolol
nadolol
propranolol

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127
Q

Other Agents meds

A

ranolazine
ivabradine
trimetazidine

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128
Q

Amlodipine oral bioavailability

A

75%

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129
Q

Amlodipine excreted unchanged in urine

A

10%

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130
Q

Amlodipine elimination half life

A

40 hours

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131
Q

Felodipine oral bioavailability

A

20%

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132
Q

Felodipine excreted unchanged in urine

A

1%

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133
Q

Felodipine elimination half life

A

14 hours

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134
Q

Nicardipine oral bioavailability

A

35%

135
Q

Nicardipine excreted unchanged in urine

A

1%

136
Q

Nicardipine elimination half life

A

3 hours

137
Q

Nifedipine oral bioavailability

A

60%

138
Q

Nifedipine excreted unchanged in urine

A

1%

139
Q

Nifedipine elimination half life

A

3 hours

140
Q

Nimodipine oral bioavailability

A

13%

141
Q

Nimodipine excreted unchanged in urine

A

<1%

142
Q

Nimodipine elimination half life

A

1.5 hours

143
Q

Diltiazem oral bioavailability

A

55%

144
Q

Diltiazem excreted unchanged in urine

A

3%

145
Q

Diltiazem elimination half life

A

5 hours

146
Q

Verapamil oral bioavailability

A

25%

147
Q

Verapamil excreted unchanged in urine

A

3%

148
Q

Verapamil elimination half life

A

5 hours

149
Q

Digitalis glycoside meds

A

digoxin

digoxin immune fab

150
Q

Adrenoceptor agonist meds

A

dobutamine

151
Q

Phosphodiesterase inhibitor meds

A

milrinone

152
Q

Vasodilators angiotensin inhibitors meds

A

enalapril

valsartan

153
Q

Vasodilators neprilysin inhibitor meds

A

sacubitril

154
Q

Other vasodilators

A

hydralazine
isosorbide dinitrate
nesiritide

155
Q

Beta Adrenoceptor blocker med

A

carvedilol

156
Q

Aldosterone antagonists meds

A

spironolactone

eplerenone

157
Q

Diuretic med

A

furosemide

158
Q

Digoxin cardiac effect

A

increases parasympathetic tone and decreases sympathetic tone

159
Q

Dobutamine cardiac effect

A

increases blood pressure

160
Q

Milrinone cardiac effect

A

reduces blood pressure

161
Q

ACE inhibitors cardiac effect

A

reduces blood pressure

162
Q

Hydralazine cardiac effect

A

reduces blood pressure

163
Q

Isosorbide dinitrate cardiac effect

A

reduces pulmonary congestion

164
Q

Nesiritide cardiac effect

A

reduces venous and arterial blood pressure

165
Q

Loop-acting diuretics (furosemide and others) cardiac effect

A

reduces edema and congestion

166
Q

Carvedilol cardiac effect

A

blocks a- and B- adrenoceptors

167
Q

Digoxin oral bioavailability

A

75%

168
Q

Digoxin onset of action

A

1 hour

169
Q

Digoxin duration of action

A

24 hours

170
Q

Digoxin elimination half life

A

36 hours

171
Q

Digoxin excreted unchanged in urine

A

60%

172
Q

Digoxin therapeutic serum level

A

0.5-2 ng/mL

173
Q

Dobutamine onset of action

A

1 minute

174
Q

Dobutamine duration of action

A

<10 minutes

175
Q

Dobutamine elimination half-life

A

2 minutes

176
Q

Dobutamine excreted unchanged in urine

A

0%

177
Q

Milrinone onset of action

A

3 minutes

178
Q

Milrinone duration of action

A

variable

179
Q

Milrinone elimination half life

A

4 hours

180
Q

Milrinone excreted unchanged in urine

A

60%

181
Q

Digoxin common adverse effects

A
  • anorexia
  • nausea and vomiting
  • arrhythmias
  • blurred vision
  • chromatopsia
  • gynecomastia
  • seizures
182
Q

Digoxin common drug interactions

A
  • antacids
  • cholestyramine
  • diltiazem
  • quinidine
  • verapamil
183
Q

Dobutamine common adverse effects

A

excessive vasoconstriction and tachyarrhythmias

184
Q

Dobutamine common drug interactions

A

adrenoceptor agonists and antagonists

185
Q

Milrinone common adverse effects

A
  • arrhythmias
  • hypotension
  • thrombocytopenia
186
Q

Milrinone common drug interactions

A

unknown

187
Q

Thiazide and related diuretics meds

A

hydrochlorothiazide

indapamide

188
Q

Loop diuretics meds

A

ethacrynic acid

furosemide

189
Q

Potassium sparing diuretics meds

A

amiloride
spironolactone
triamterene

190
Q

Osmotic diuretics meds

A

glycerol

mannitol

191
Q

Carbonic anhydrase inhibitors meds

A

acetazolamide

dorzolamide

192
Q

Antidiuretic hormone antagonists meds

A

conivaptan

193
Q

Furosemide oral bioavailability

A

60%

194
Q

Furosemide elimination half life

A

2 hours

195
Q

Furosemide duration of action

A

7 hours oral

2 hours IV

196
Q

Torsemide oral bioavailability

A

80%

197
Q

Torsemide elimination half life

A

3.5 hours

198
Q

Torsemide duration of action

A

7 hours oral

7 hours IV

199
Q

Amiloride oral bioavailability

A

20%

200
Q

Amiloride elimination half life

A

8 hours

201
Q

Amiloride duration of action

A

24 hours oral

202
Q

Spironolactone oral bioavailability

A

65%

203
Q

Spironolactone elimination half life

A

1.5 hours

204
Q

Spironolactone duration of action

A

60 hours oral

205
Q

Triamterene oral bioavailability

A

50%

206
Q

Triamterene elimination half life

A

4 hours

207
Q

Triamterene duration of action

A

14 hours oral

208
Q

Glycerol oral bioavailability

A

95%

209
Q

Glycerol elimination half life

A

0.07 hours

210
Q

Glycerol duration of action

A

1 hour oral

211
Q

Mannitol elimination half life

A

1 hour

212
Q

Mannitol duration of action

A

7 hours IV

213
Q

Acetazolamide oral bioavailability

A

70%

214
Q

Acetazolamide elimination half life

A

7.5 hours

215
Q

Acetazolamide duration of action

A

10 hours oral

216
Q

Dorzolamide duration of action

A

8 hours topical

217
Q

Hydrochlorothiazide common adverse effects

A
  • blood cell deficiencies
  • electrolyte imbalances
  • increased blood cholesterol, glucose, or uric acid levels
218
Q

Hydrochlorothiazide common drug interactions

A

potentiates the diuretic effect of loop diuretics

219
Q

Indapamide common adverse effects

A
  • electrolyte imbalances

- increased blood cholesterol, glucose, or uric acid levels

220
Q

Indapamide common drug interactions

A

potentiates the diuretic effect of loop diuretics

221
Q

Metolazone common adverse effects

A
  • blood cell deficiencies
  • electrolyte imbalances
  • increased blood cholesterol or glucose levels
222
Q

Metolazone common drug interactions

A

potentiates the diuretic effect of loop diuretics

223
Q

Bumetanide common adverse effects

A
  • blood cell deficiencies
  • electrolyte imbalances
  • hearing impairment
  • rash
224
Q

Bumetanide common drug interactions

A
  • diuretic effect decreased by NSAIDs

- administration with ACE inhibitors may cause excessive hypotension

225
Q

Ethacrynic acid common adverse effects

A
  • blood cell deficiencies
  • electrolyte imbalances
  • hearing impairment
  • rash
226
Q

Ethacrynic acid common drug interactions

A

diuretic effect decreased by NSAIDs

227
Q

Furosemide common adverse effects

A
  • blood cell deficiencies
  • electrolyte imbalances
  • hearing impairment
  • hypersensitivity reactions
  • increased blood cholesterol, glucose, or uric acid levels
  • photosensitivity
228
Q

Furosemide common drug interactions

A
  • diuretic effect decreased by NSAIDs

- administration with ACE inhibitors may cause excessive hypotension

229
Q

Torsemide common adverse effects

A
  • electrolyte imbalances

- increased blood cholesterol, glucose, or uric acid levels

230
Q

Torsemide common drug interactions

A
  • diuretic effect decreased by NSAIDs

- administration with ACE inhibitors may cause excessive hypotension

231
Q

Amiloride common adverse effects

A
  • blood cell deficiencies
  • gastrointestinal distress
  • hyperkalemia
232
Q

Amiloride common drug interactions

A
  • administration with ACE inhibitors or potassium supplements may cause hyperkalemia
  • administration with NSAIDs may cause renal failure
233
Q

Spironolactone common adverse effects

A

gynecomastia, hyperkalemia, and impotence

234
Q

Spironolactone common drug interactions

A

administration with ACE inhibitors or potassium supplements may cause hyperkalemia

235
Q

Triamterene common adverse effects

A
  • blood cell deficiencies
  • gastrointestinal distress
  • hyperkalemia
236
Q

Triamterene common drug interactions

A
  • administration with ACE inhibitors or potassium supplements may cause hyperkalemia
  • administration with NSAIDs may cause renal failure
237
Q

Glycerol common adverse effects

A
  • heart failure
  • nausea and vomiting
  • pulmonary congestion and edema
238
Q

Glycerol common drug interanctions

A

potentiates effects of other diuretics

239
Q

Mannitol common adverse effects

A
  • heart failure
  • nausea and vomiting
  • pulmonary congestion and edema
240
Q

Mannitol common drug interactions

A

potentiates effects of other diuretics

241
Q

Acetazolamide common adverse effects

A
  • blood cell deficiencies
  • drowsiness
  • hepatic insufficiency
  • hyperglycemia
  • hypokalemia
  • metabolic acidosis
  • paresthesia
  • uremia
242
Q

Acetazolamide common drug interactions

A
  • serum levels of weak bases are increased by CA inhibitors

- CA inhibitors are increased by salicylates

243
Q

Dorzolamide common adverse effects

A
  • bitter taste
  • blurred vision
  • ocular discomfort
  • allergic reactions
244
Q

Sodium channel blockers meds

A

disopyramide
lidocaine
propafenone

245
Q

Beta Adrenoceptor Blockers med

A

metoprolol

246
Q

Potassium channel blockers meds

A 
amiodarone 
dronedarone 
ibutilide 
dofetilide 
sotalol
247
Q

Calcium channel blockers med

A

diltiazem

248
Q

Miscellaneous cardiac dysrhythmias meds

A 
adenosine 
digoxin 
magnesium sulfate
ivabradine 
ranolazine
249
Q

Disopyramide oral bioavailability

A

90%

250
Q

Disopyramide onset of action

A

1 hour

251
Q

Disopyramide duration of action

A

6 hours

252
Q

Disopyramide elimination half life

A

7 hours

253
Q

Disopyramide excreted unchanged in urine

A

50%

254
Q

Procainamide oral bioavailability

A

85%

255
Q

Procainamide onset of action

A

1 hour

256
Q

Procainamide duration of action

A

5 hours

257
Q

Procainamide elimination half life

A

3.5 hours

258
Q

Procainamide excretion unchanged in urine

A

55%

259
Q

Quinidine oral bioavailability

A

75%

260
Q

Quinidine onset of action

A

1 hour

261
Q

Quinidine duration of action

A

7 hours

262
Q

Quinidine elimination half life

A

6 hours

263
Q

Quinidine excreted unchanged in urine

A

30%

264
Q

Lidocaine elimination half life

A

1.5 hours

265
Q

Lidocaine excreted unchanged in urine

A

1%

266
Q

Mexiletine oral bioavailability

A

90%

267
Q

Mexiletine onset of action

A

1 hour

268
Q

Mexiletine duration of action

A

10 hours

269
Q

Mexiletine elimination half life

A

11 hours

270
Q

Mexiletine excreted unchanged in urine

A

10%

271
Q

Flecainide oral bioavailability

A

75%

272
Q

Flecainide onset of action

A

3 hours

273
Q

Flecainide duration of action

A

21 hours

274
Q

Flecainide elimination half life

A

14 hours

275
Q

Flecainide excreted unchanged in urine

A

30%

276
Q

Propafenone oral bioavailability

A

10%

277
Q

Propafenone onset of action

A

3 hours

278
Q

Propafenone duration of action

A

10 hours

279
Q

Propafenone elimination half life

A

6 hours

280
Q

Propafenone excreted unchanged in urine

A

<1%

281
Q

Esmolol onset of action

A

<5 minutes

282
Q

Esmolol duration of action

A

20-30 minutes

283
Q

Esmolol elimination half life

A

0.15 hours

284
Q

Esmolol excreted unchanged in urine

A

<2%

285
Q

Metoprolol oral bioavailability

A

35%

286
Q

Metoprolol onset of action

A

1 hour

287
Q

Metoprolol duration of action

A

15 hours

288
Q

Metoprolol elimination half life

A

3.5 hours

289
Q

Metoprolol excreted unchanged in urine

A

7%

290
Q

Propranolol oral bioavailability

A

35%

291
Q

Propranolol onset of action

A

0.5 hour

292
Q

Propranolol duration of action

A

4 hours

293
Q

Propranolol elimination half life

A

4 hours

294
Q

Propranolol excreted unchanged in urine

A

<0.5%

295
Q

Amiodarone oral bioavailability

A

45%

296
Q

Amiodarone onset of action

A

2 weeks

297
Q

Amiodarone duration of action

A

4 weeks

298
Q

Amiodarone elimination half life

A

40 days

299
Q

Amiodarone excreted unchanged in urine

A

0%

300
Q

Dofetilide oral bioavailability

A

90%

301
Q

Dofetilide onset of action

A

1 hour

302
Q

Dofetilide duration of action

A

12 hours

303
Q

Dofetilide elimination half life

A

10 hours

304
Q

Dofetilide excreted unchanged in urine

A

80%

305
Q

Ibutilide onset of action

A

5 minutes

306
Q

Ibutilide elimination half life

A

6 hours

307
Q

Ibutilide excreted unchanged in urine

A

<10%

308
Q

Sotalol oral bioavailability

A

90%

309
Q

Sotalol onset on action

A

2 hours

310
Q

Sotalol duration of action

A

15 hours

311
Q

Sotalol elimination half life

A

12 hours

312
Q

Sotalol excreted unchanged un urine

A

90%

313
Q

Diltiazem oral availability

A

55%

314
Q

Diltiazem onset of action

A

2 hours

315
Q

Diltiazem duration of action

A

8 hours

316
Q

Diltiazem elimination half life

A

5 hours

317
Q

Diltiazem excreted unchanged in urine

A

3%

318
Q

Verapamil oral bioavailability

A

25%

319
Q

Verapamil onset of action

A

2 hours

320
Q

Verapamil duration of action

A

9 hours

321
Q

Verapamil elimination half life

A

5 hours

322
Q

Verapamil excreted unchanged in urine

A

3%

323
Q

Adenosine onset of action

A

30 seconds

324
Q

Adenosine duration of action

A

1.5 minutes

325
Q

Adenosine elimination half life

A

<10 seconds

326
Q

Adenosine excreted unchanged in urine

A

0%

327
Q

Digoxin oral bioavailability

A

75%

328
Q

Digoxin onset of action

A

1 hour

329
Q

Digoxin duration of action

A

24 hours

330
Q

Digoxin elimination half life

A

35 hours

331
Q

Digoxin excreted unchanged in urine

A

60%

332
Q

Magnesium onset of action

A

<5 minutes

333
Q

Magnesium sulfate excreted unchanged in urine

A

100%

PCOL 406 (1 decks)

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