PBC Flashcards
1
Q
PBC
Patho
CF
A
T-lymphocyte mediated attack on small intralobular bile ducts –>destruction –> disappearance
- Sx of LFT derangement - lethargy, pruritus, jaundice
- Skin pigmentation
- a/w other autoimmune conditions: Sjogren’s, Autoimmune thyroid d/o, CREST, RA
- mostly young women
2
Q
PBC
Ix
A
AMA **
ANA, bili, ALP
No obstruction on USS
Sx of CLD
3
Q
PBC Bx
A
portal inflammatory infiltrate with a granulomatous component centered on small bile ducts
4
Q
pbc Cx
A
Liver cirrhosis
HCC
Cx of CLD
Metabolic bone disease
5
Q
PBC Management
A
Ursodeoxycholic acid
Others - ETOH abstinence, immunisations surveillance
6
Q
Ursodeoxycholic acid MOA
A
Decreases the cholesterol content of bile and bile stones by reducing the secretion of cholesterol from the liver and the fractional reabsorption of cholesterol by the intestines.
