Paulson - Disorders of Lower GI Tract Flashcards
constipation is defined as
< 3 stools/week
constipation etiologies (8)
inadequate fiber/water
meds
neuro conditions
prolonged immobility
metabolic dz’s
functional fecal retention
anatomic abnormalities
functional abnormalities
what meds are associated w. constipation
opioids
anticholinergic
CCBs
antacids
iron
what neuro conditions are associated w. constipation (4)
MS
Parkinsons
dementia
stroke
what metabolic dz’s are associated w. constipation (5)
DM
hypothyroidism
uremia
hypercalcemia
hypokalemia
what is functional fecal retention
chronic stool withholding
think kids
tx for constipation (4)
fiber
hyperosmolar agents → sorbitol, lactose
stimulant → glycerin suppository, dulcolax
enema → mineral or tap water
when should you use an opioid antagonist for constipation
only in terminally ill pt
what are 2 examples of opioid antagonists
relistor
naloxegol
what is a complication of chronic constipation
fecal impaction
fecal impaction is mc in
kids
elderly
fecal impaction is mc found in
rectum
distal sigmoid colon
what are 5 sx of fecal impaction
abd pain
bloating
overflow fecal incontinence
paradoxical diarrhea
increased urinary frequency
what might you see on pe for fecal impaction
impacted feces on DRE
what imaging is used for fecal impaction
xray or CT→ location of impaction and any associated obstruction
tx for fecal impaction (4)
manual disimpaction
enema
osmotic laxatives
address underlying cause
serious complication of fecal impaction
large bowel obstruction w. colonic perforation → high mortality
celiac disease is same same
gluten insensitivity
nontropical sprue
sx of celiac dz
diarrhea w bulky foul smelling bm
floating stools
steatorrhea
flatulence
wt loss
weakness
abd distension
FTT w/ infants/kids
IDA
osteopenia/porosis
what conditions are associated w. celiac
dermatitis herpetiformis
DM1
Down’s syndrome
liver dz
menstrual/reproductive issues
common presenting sign for celiac
dermatitis herpetiformis → grouped pruritic papules/vesicles
rf for celiac (5)
1st/2nd degree relative w. confirmed CD
T1DM
AI thyroiditis
down syndrome
turner syndrome
preferred serologic test for celiac
TTGIGA abs test
2nd line dx test for celiac
EMA-IgA
test to confirm celiac
small bowel bx x 4
what do you think when you see: atrophic appearing mucosa w. loss of folds, visible fissures, nodularity, scalloping, prominent submucosal vascularity
small bowel bx findings for celiac
dx testing for pt w. high probability of CD (classic presentation + rf)
blood test
PLUS
bx
dx testing for pt w. low probability of CD (not classic presentation, no rf)
serologic testing
does negative serology r.o celiac
no!
tx for celiac
gluten free diet
RD referral
replete nutritional deficiencies
DXA
pneumococcal vaccination
screen family members
education regarding dermatitis for celiac pt
improvement of rash more delayed than intestinal manifestations
mc cause of anal fissures
local trauma
other causes of anal fissures
constipation
anal sex
diarrhea
vaginal delivery
causes of secondary anal fissures (3)
IBD
malignancy
STI
mc location for anal fissures
2nd mc location for anal fissures
posterior midline
anterior midline
acute anal fissures will appear
fresh
superficial
like a papercut
chronic anal fissures will appear
raised edges
fibrotic appearance
often w. skin tag (sentinel pile)
sx of anal fissures
anal pain → intensifies w. bm
ripping/tearing feeling → can last for hours
+/- anal bleeding
dx for anal fissures (2)
direct visualization
reproduce pain w. digital palpation of posterior anal verge
tx for anal fissures
fiber + water
+/- stool softeners
sitz bath
topical analgesics
topical vasodilators
2 ex of topical vasodilators
nifedepine gel
topical nitroglycerin
IBD includes
crohn’s
uc
rf for IBD (4)
15-40 yo
jewish
1st degree relative w. hx
western diet
highest risk for IBD
western diet
smoking is protective for __
and rf for __
UC
crohn’s
UC always starts __ at the rectum
and progresses __
in a __ manner
distally
proximally
continuous circumferential
UC is characterized by no __ progression
skips
UC is characterized by inflammation in the mucosa of the
colon
onset of UC is
gradual/progressive
PE for UC is usually __,
but might include (6)
ttp
fever
hypotn
tachycardia
pallor
blood on rectal exam
2 common sx of UC
bloody diarrhea
frequent BMs that are smaller in volume
if UC is mainly distal, symptoms may include (4)
constipation + frequent blood/mucus d.c
incontinence
colicky abd pain
systemic systems
systemic sx in UC include (3)
fever
weight loss
fatigue
extraintestinal sx affect what systems
joints
eyes
skin
bv
gallbladder
what joint sx are associated w. UC (2)
nondestructive peripheral arthritis of large joints
ankylosing spondylitis
what eye sx are associated w. UC
episcleritis
uveitis
what is this condition
episcleritis
what is this condition
uveitis
what skin sx are associated w. UC
erythema nodosum
pyoderma gangrenosum
what is this condition
pyoderma nodosum
what is this condition
erythema nodosum
what bv conditions are associated w. UC (3)
VTE
arterial thromboembolism
AI hemolytic anemia
what other GI condition has a strong association w. UC
primary sclerosing cholangitis
labs abnormalities associated w. UC (4)
anemia
elevated ESR/CRP
electrolyte abnormalities
fecal calprotectin
elevated fecal calprotectin is a marker of
active inflammation in the GI tract
is imaging required for dx of UC
no!
what imaging might you use in UC (4)
xray
double contrast barium enema
CT/MRI
bx
xray findings associated w. UC (3)
proximal constipation
mucosal thickening or “thumbprinting”
colonic dilation → if severe
what do you think of when you see, microulcerations, collar button ulcers, loss of haustra, pseudopolyps
UC findings on barium enema
what are pseudopolyps
mass of scar tissue from granulation
you should avoid barium enemas in __
bc it can cause __
severely ill
megacolon
what type of imaging is this and what is it showing
barium enema
loss of haustra → smooth featureless colon
UC
what are haustra
folds in sigmoid colon
what imaging is this and what is it showing
barium enema
microulcerations (white spots)
UC
what type of imaging is this and what is it showing
barium enema
pseudopolyps w. stricture
UC
what type of imaging is lower sensitivity for UC and is not used for dx
CT/MRI
what do you think when you see, loss of vascular markings from swelling of mucosa; petechiae; exudates, edema; erosions that are friable to touch; and spontaneous bleeding
endoscopic findings of UC
what imaging is this and what is it showing
endoscopy
petechiae
bleeding
UC
what is this endoscopy showing
pseudopolyps
UC
what do you think of when you see, crypt abscesses; shortenings and disarray; crypt atrophy; epithelial cell abnormalities; mucin depletion; paneth cell metaplasia; inflammatory features
bx findings of UC
4 dx factors for UC
- chronic diarrhea x at least 4 weeks
- e.o active inflammation on endoscopy
- chronic changes on bx
- exclusion of other causes
what do you think when you see, lamina propria cellularity, basal plasmacytosis, basal lymphoid aggregates, lamina propria eosinophios
inflammatory findings of bx for UC
in UC progression, there are no __ areas of mucosa
normal
mild UC parameters (3)
4 or less stool/day without blood
normal ESR
no systemic sx → severe abd pain, fever, wt loss, profuse bleeding
moderate UC parameters (5)
more than 4 bloody stools/day
mild anemia → does not require transfusion
moderate abd pain
minimal signs of systemic toxicity
no wt loss
severe UC parameters (4)
6 or more frequent, loos bloody stools/day
severe abd pain
systemic sx
+/- rapid wt loss
4 systemic sx considerations in US severity grading
fever
tachycardia
anemia
elevated ESR
first step in tx of UC
classify severity of dz
what is the most distal manifestation of UC
ulcerative proctitis or proctosigmoiditis
first line tx for ulcerative proctitis or proctosigmoiditis
topical 5-aminosalyclic acid (5-ASA)
5-ASA offers __
and __ for UC
symptomatic relief
AND
decreased bleeding
5-ASA acts quickly and can cause complete healing in
4-6 weeks
if a pt has complete healing of UC following 5-ASA tx, how should you d.c med
continue 8 weeks longer → then taper
how should you administer 5-ASA for UC
suppository and/or enema