Pattison - Drugs Flashcards
What is the mechanism of action of 5-FU?
Metabolized to F-dUMP, subsequently binds to ad inhibits thymidylate synthase, thus blocking synthesis of Thymine and preventing DNA synthesis.
What is the mechanism of Action of Ara-C?
Converted to cytosine arabinoside triphosphate, which damages DNA, halting the cell cycle.
What viruses are typically targeted by Acyclovir?
Heroes Simplex Virus, chicken pox, and shingles
This drug is converted to F-dUMP, which irreversibly binds TS.
5-Fluorouracil
What type of drug is Acyclovir?
Nucleoside Analog
What class of drug is Zidovudine?
Reverse Transcriptase Inhibitor
Also a pyrimidine-Thymine Analog) (nucleotide/nucleoside Analog
This drug is a deoxyguanosine Analog.
Acyclovir
To what is Cytarabine converted in the cell?
Cytosine Arabinoside Triphosphate
What is the mechanism of action of Zidovudine (ZDV)?
Binds and inhibits reverse transcriptase. Lacks 3’-OH group, causing chain termination.
This drug is also known as cytosine arabinoside (Ara-C).
Cytarabine
This nucleoside Analog targets viral DNA, but may affect mitochondrial DNA, causing side effects like bone marrow suppression.
Acyclovir
By what other names does Zidovudine go by?
ZDV, azidothymidine, AZT, or Retrovir.
This thymine Analog can be used to treat HIV/AIDS.
Zidovudine
This nucleoside Analog can be used to treat AML, ALL, CML, Non-Hodgkins Lymphoma, and occasionally some viruses.
Cytarabine
What type of drug is is Cytarabine?
Nucleoside Analog
