Patient Education & Patient Focused Considerations Flashcards
INSULIN INTERACTIONS:
that increases glucose, antagonize insulin
corticosteroids
diuretics
thyroid drugs
sympathomimetic drugs
niacin
INSULIN INTERACTIONS:
increase hypoglycemic, decrease blood glucose
alcohol
sulfa antibiotics
anabolic streoids
MAOIs
Salicylates
INSULIN INTERACTIONS:
masks triglycerides, risk of not noticing HYPOGLYCEMIA
Non selective beta blockers
Age related changes have a dramatic effect on_______
Increased risk of adverse effects and toxicity at ?
Age related changes have a dramatic effect on pharmacokinetics (ADME)
Increased risk of adverse effects and toxicity at both ends of spectrum of life (newborn and OA)
Drugs cross the placenta primarily by _______.
diffusion
Placenta- access fetus by diffusion (high con to lower cont)
Factors Affecting Pregnancy Safety? (3)
Drug properties
Fetal gestational age
Maternal factors
frequency, doses
fetal gestational age (40 weeks): the greatest risk is in 1st trimester- due to rapid proliferation
maternal factor- kidney/live/ genetic
US Food and Drug Administration (FDA) has implemented?
REVISED pregnancy safety categories.
Drug levels in breast milk are usually ___ than in maternal circulation
Exposure depends on ___ of consumed milk
lower
volume
Drug Therapy During Breastfeeding
Breastfed infants are at risk for exposure to drugs consumed by the mother
Breast milk is not the primary route for maternal drug excretion
Consider risk–benefit ratio
Drug transfer to a fetus is most likely to occur in ____ semester- blood flow to fetus is highest, and are more likely to absorb it
LAST trimester
premature/ preterm infant
younger than 38 weeks gestation
neonate/ newborn infant
younger than 1 month
infant
1 month to younger than 1 yr
child
1 yr to younger than 12 yr
adolescent
13 to 19 yr
Neonatal and Pediatric Considerations: Pharmacokinetics
Absorption
- Gastric pH until 1 to 2 years
- Gastric emptying
- First pass elimination
- Bile salt formation,
- Bioavailability
- Intramuscular absorption
Gastric pH LESS acidic (MORE BASIC) until 1 to 2 years of age
Gastric emptying SLOWED- drug stays longer
First-pass elimination REDUCED- immature liver, more free drug is more available and can lead to toxicity
REDUCED bile salt formation
REDUCED bioavailability
***Intramuscular absorption FASTER and irregular
Neonatal and Pediatric Considerations:
Dose of drug and why?
IMMATURE vital organs absorption is affected
DECREASE the amount of drug they get
They get LOWER DOSE due to risk for toxicity
Neonatal and Pediatric Considerations:
Distribution
- total body water differences result in
- total body water, means?
- protein binding
- blood-brain barrier
Total body water differences result in INCREASED distribution and dilution of water-soluble drugs.
GREATER total body water means lower fat content.
DECREASED level of protein binding (low albumin)
IMMATURE blood–brain barrier means more drugs enter the brain
Neonatal and Pediatric Considerations:
Metabolism
- Liver function, production of enzymes
- Older children’s differences from younger ones, and dosage and frequent requirement
- Other factors to consider
Liver IMMATURE; does not produce enough microsomal enzymes
Older children may have increased metabolism, requiring higher doses or more frequent administration than infants.
Other factors: liver enzyme production, genetic differences, and substances to which the mother may have been exposed during pregnancy
Dosage consideration for younger individuals
Decrease the dose= first pass effect affects ORAL meds, in the liver (has detoxify effects)
Neonatal and Pediatric Considerations: Pharmacokinetics
Excretion
- Kidney function, what does it affect
- Perfusion rate of kidneys
Kidney IMMATURITY affects GLOMERULAR FILTRATION RATE and tubular secretion.
DECREASED perfusion rate of the kidneys may reduce the excretion of drugs.
Factors Affecting Pediatric Drug Dosages
- Skin is
- Stomach lacks
- Lungs have
- Body temperature (what can occur)
- Liver and kidneys
Skin is thin and permeable.
Stomach lacks acid to kill bacteria.
Lungs have weaker mucus barriers.
Body temperatures are less well regulated, and dehydration occurs easily.
Liver and kidneys are immature, impairing drug metabolism and excretion.
Methods of Dosage Calculation for Pediatric Patients?
ALWAYS USE… 2
Body surface area method
~~~Uses the West nomogram
Always use weight in kilograms, not pounds.
Always use height in centimeters, not inches.
Body weight dosage calculations
Uses mg/kg
Weigh and measure child!!
General Considerations
Prepare all equipment and supplies first.
Have caregivers stay as appropriate.
Assess for comfort methods before, during, and after drug administration.
Infants
Toddlers
Preschoolers
School-age children
Adolescents
Older Adult Patients
5 NURSING CONSIDERATIONS
High use of medications
Polypharmacy
Nonadherence
Increased incidence of chronic illnesses
Sensory and motor deficits
Older adults age
older than age 65 years
Older adults
- Cardiovascular
CO
Blood flow
DECREASE OUTPUT= DECREASE ABSORPTION + DISTRIBUTION
DECREASE BLOOD FLOW= DECREASE ABSORPTION + DISTRIBUTION
OLDER ADULTS
- GI Tract
pH
Peristalsis
INCREASE PH (ALKALIME GASTRIC SECRETIONS) = ALTERED ABSORPTION
DECREASE PERISTALSIS = DELAYED GASTRIC EMPTYING
OLDER ADULTS
- Liver
Enzyme Production
DECREASE ENZYME PRODUCTION = DECREASE METABOLISM
OLDER ADULTS
- KIDNEY
BLOOD FLOW
KIDNEY FUNCTION
GFR
DECREASED BLOOD FLOW= DECREASED METABOLISM + DECREASED EXCRETION
DECREASE FUNCTION = DECREASE EXCRETION
DECREASE GFR = DECREASE EXCRETION
Older Adults: Pharmacokinetics
ABSORPTION
- pH
- gastric emptying
- GI tract movement
- BLOOD FLOW
- absorptive surface of GI TRACT
Gastric pH less acidic (like little babies)
Gastric emptying slowed
Movement through gastrointestinal (GI) tract slowed because of decreased muscle tone and activity
Blood flow to GI tract reduced
Decrease CO = decrease blood flow to major organs = decrease absorption (ABSORPTION FROM THE GI TRACT, CIRCULATION, LIVER, SYSTEMIC CIRCULATION)
Absorptive surface of GI tract reduced
Decreased ability of stomach to produce HCL
DECREASE muscle tone and activity in GI tract
OLDER ADULTS dosage
Decreased absorption of drugs- increase the dose for therapeutic response
start low, go slow
Older Adults: Pharmacokinetics
DISTRIBUTION
- TOTAL BODY WATER %
- FAT CONTENT
- PROTEIN PRODUCTION and relationship to binding of drugs
Lower total body water percentages (unlike infants)
Increased fat content (less lean muscle)
Decreased production of proteins by the liver, resulting in decreased protein binding of drugs (and increased circulation of free drugs)
Older Adults: Pharmacokinetics
Metabolism
- Production of enzymes in the liver
- Blood flow to the liver
- leads to a prolonged ____ of many drugs
- potential for _______ if not monitored
Aging liver produces fewer microsomal enzymes, affecting drug metabolism.
Blood flow to the liver is reduced- accumulation and toxicity
Leads to a prolonged half-life of many drugs
~~~Potential for accumulation if not monitored
Older Adults: Pharmacokinetics
Excretion
- GFR, why?
- Number of intact neurons
Decreased glomerular filtration rate due to decreased BF, and CO
Decreased number of intact nephrons
(Decreased GFR, CO, kidney perfusion and intact nephrons > delayed drug excretion and drug accumulation)
Liver function test
AST, ALT-assess ability to metabolize and eliminate meds > risk for toxicity and accumulation
Kidney test
Creatinine, BUN, urea, nitrogen, GFR
Opioid effects in OA
confusion, constipation, urinary retention, nausea, vomitoing, respiratory depression, falls
NSAIDs in OA
edema, nausea, gastric ulceration, bleeding, kidney toxicity
Antichollinergics and antihistamine in OA
blurred vision, dry mouth, constipation, and sedation, urinary retention, tachycardia
Anticoagulants in OA
major/ minor bleeding episodes, many drug interactions, dietary interactions
Antihypertensives
nausea, hypotension, diarrhea, bradycardia, heart failure, impotence
Antidepressants
sedation, strong cholinergic adverse effects
Cardiac glycosides
visual disorders, nausea, diarrhea, dysrhythmia, hallucinations, decreased apetite, weight loss
Older Adults: Beers Criteria for Prevention of Adverse Drug Events
A listing of drug and drug classes to be avoided in older adults
Identified disease states considered to be contraindications for some drugs
Three categories:
Potentially Inappropriate Drugs and classes in Older Adults
Potentially inappropriate medications to avoid with certain diseases
Medications to be used with caution in older adults
ISNP-SAFE MEDICATIONS FOR OAs