Pathophysiology of MS Flashcards
MS is considered a…
Autoimmune condition
MS is caused by…
Inflammation to myelin on nerves, leading to demyelination + axonal degeneration in CNS
Etiology of MS may result from…
A combination of immunological, genetic, environmental, and infectious factors
Common symptoms of MS that may be present pre-diagnosis include…
Numbness, tingling, weakness, + muscle spasms - difficulty walking
Fatigue, pain
Cognitive dysfunction
Bladder + bowel dysfunction
4 Types of MS include…
Relapsing-remitting (relapses predictable)
Secondary progressive (permanent damage after relapse)
Primary progressive (increasing disability over time)
Clinically isolated syndrome (2nd attack not present)
Brain lesions indicate ____, which can be used to…
Active inflammation - identify MS early
Amount of inflammation tends to be ____ in relapse, and ____ in progressive states because…
This is relevant because??
High in relapse - lower in progressive states since axon is already damaged
Majority of MS drugs try to decrease inflammation
Increasing disability + axonal loss is associated with ____ disease
Progressive
Progression of MS is measured using…
EDSS - expanded disability status scale
Non-pharmacological management of MS may include…
Exercise
Diet
Complementary/alternative medicine
Goals of therapy for MS include…
Treating acute relapses
Treating/managing symptoms
Prevent disease activity and progression
