Pathophysiology Exam #2 Flashcards
What percentage of body weight does blood make up?
8%
What percentage of blood does the plasma make up?
55%
What percentage of blood does the formed elements make up?
45%
Most of the plasma is formed of ____?
Water, 91%
Proteins make up what percentage of plasma?
7%
What is the main contributor to the protein of the blood?
Albumin
Other solutes such as gases, ions, nutrients and waste make up what percentage of plasma?
2%
When we measure the “formed elements” in the blood we are measuring its?
hematocrit
Most of the formed elements are made up of these ____?
RBCs
What is the normal range of RBCs in the blood?
4.2 - 6.2 million/cubic millmeter(or microliter[microl])
What are the two main functions of RBCs?
Transport oxygen to the tissues via iron molecules
Transport carbon dioxide to lungs to be exhaled(CO2 is partially dissolved in the cytoplasm of RBCs and partially bound with hemoglobin
Oxygen binds with the ___ portion of hemoglobin, while carbon dioxide binds with the ___ portion of hemoglobin.
- heme
- globin
Red Blood Cells contains this enzyme that is responsible for?
-carbonic anhydrase(metabolizes the reaction of CO2 and Water)
-a weak acid that allows for carbon dioxide to be transported in the cytoplasm of RBCs
CO2 + H2O H2CO3 H+ HCO3-
How does hemoglobin serve as a powerful acid-base buffer to regulate the pH of body fluids?
By binding to excess H+ ions if there is an increase in them….if there is a deficit of H+ ions then Hgb will release H+ increasing the concentration of them in body fluids
When carbonic anhydrase is present with CO2 and water, what will be formed?
- Carbonic acid(H2CO3)
- carbonic acid can be formed of water/CO2 without carbonic anhydrase, but it happens much slower
Carbonic anhydrase increases the reaction between CO2 and Water about _____ times.
5000
Carbonic acid is a weak acid that disassociates weakly…forming what?
- H+
- HCO3-
CO2 + H2O H2CO3 H+ HCO3-
These elements can go either way either left to right or right to left. What is different when H+ and HCO2 become carbonic acid as opposed with CO2+H2) becomes carbonic acid?
H+ and HCO2 do not need carbonic anhydrase to form carbonic acid
CO2 + H2O H2CO3 H+ HCO3-
What determines which way the reaction takes place?
The number of reactants on each side. For example…if CO2 increases it is going to combine with water with CA and become H2CO3….if HCO2 increases it drives the reaction the other way.
What is the all important Acid Base formula?
CO2 + H2O H2CO3 H+ HCO3-
What is the normal RBC in men?
5,200,000/mm^3(or microl)
What is the normal RBC in women?
4,700,000/mm^3(or microl)
What are two factors why there is a higher RBC in men than women?
- men have higher testosterone which stimulates RBC
- women have menses
What is the normal percentage of the formed elements(Hct.) part of the total blood volume?
38 - 52%