Pathophysiology Flashcards

1
Q

Pathophysiology

A
  • Study of changes in the normal physical, chemical or mechanical processes which cause disease
  • If you understand the cause of disease
  • You can prevent it
  • You may treat it better
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2
Q

Pathos

A

Suffering

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3
Q

Physio

A

Nature, origin

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4
Q

Ology

A

Study of

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5
Q

Homeostasis

A

•Communication within the body
-Cellular level
-Chemical signals
•Bodies internal balance

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6
Q

Negative Feedback

A
  • ”Off” switch, inhibits the original stimulus
  • Insulin released to lower BGL to normal
  • Glucose is at normal level, Insulin shuts off
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7
Q

Positive Feedback

A
  • Intensifies signal, enhances the original signal
  • Oxytocin released in larger quantities to intensify labor contractions
  • Blood clotting (platelet aggregation) at injury site is another example
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8
Q

Adaption

A

Cells exposed to adverse conditions will protect themselves from injury

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9
Q

Atrophy

A

Decrease in cell size

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10
Q

Hypertrophy

A

Increase cell size

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11
Q

Hyperplasia

A

Increase number of specific cells

Cell division

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12
Q

Dysplasia

A

Change size, shape, and organization

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13
Q

Metaphasia

A

Change type of cell

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14
Q

Hypoxic Cellular Injury

A
•MOST Common cause of cell injury 
 -Hypoxemia**
   •MOST common cause of hypoxia
 -⬇️ O2 in air
 -Loss of hemoglobin function
 -⬇️ number of red blood cells 
 -Respiratory or cardiovascular Dz
•Reversible = Ischemia 
•Irreversible = Necrosis
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15
Q

Chemical Injury

A
•Poisons 
 -Cyanide, pesticides 
•Lead
 -Brain Injury
•Carbon monoxide 
 -Hemoglobin affinity 200 times greater than O2
•Pharmacological agents
 -Drugs
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16
Q

Virulence

A

•Toxicity
-Measures potential of microorganism to cause disease
-Effectiveness of body’s defenses
-Microorganisms resistance to body’s defenses
•Invade and destroy cells
•Produce toxins
•Immunosuppressed- less able to defend

17
Q

Bacteria

A
•Normal flora
•Prokaryotic 
 -No organized nucleus 
•Capsule- protects 
•Rely on host
 -Environment 
 -Nutrition 
•Gram+ —> blue
•Gram-  —> red
 -Most
•Antibiotics 
•Septicemia 
 -Sepsis 
 -Gram(-) usually
18
Q

Bacteria

Exotoxin

A
•Gram-neg and gram-pos 
•Released from inside cell 
 -During growth 
•Many types of exotoxins 
•Heat labile 
 -Destroys
•Specific effects on hosts 
•Vaccines 
•Highly poisonous/toxic