Pathophysiology

Question 1

Pathophysiology of Type 1 Hypersensitivity reactions (2) + Examples (2)

Answer 1

1. Anaphylactic
2. IgE, Mast cells, Histamine mediated

Examples:
3. Anaphylaxis

4. Atopy - asthma, hayfever, eczema

Question 2

Pathophysiology of Type 2 Hypersensitivity reactions (2) + Examples (6)

Answer 2

1. Cell Bound
2. IgG and IgM attatch to cells surface antigens

Examples:
3. AI Haemolytic Anaemia

4. ITP
5. Goodpasture’s
6. Pernicious Anaemia
7. Acute Haemolytic Transfusion Reacitons
8. Rheumatic Fever

Question 3

Pathophysiology of Type 3 Hypersensitivity reactions (2) + Examples (3)

Answer 3

1. Immune Complex
2. Free antigen and Antibody combine and can deposit in bad places

Examples:
3. Serum Sickness

4. SLE
5. Post Streptococcal Glomerulonephritis

Question 4

Pathophysiology of Type 4 Hypersensitivity reactions (2) + Examples (2)

Answer 4

1. Delayed Hypersensitivity
2. T-Cell Mediated

Examples:
3. TB

4. Graft versus host disease
5. Allergic Contact Dermatitis
6. Scabies
7. MS
8. GBS

Question 5

Pathophysiology of Type 5 Hypersensitivity reactions (2) + Examples (2)

Answer 5

1. Abs that bind or attach cell surface receptors
2. Stimulating or turning off the receptor function

Examples:

3. Graves
4. Myasthenia Gravis