Pathophys of Alzheimer's Flashcards
1
Q
Causes of dementia
A
Primary neurodegenerative disease CVD Infectious/inflammatory disease Toxic disorders Metabolic disorders Endocrine abnormalities Structural lesions Trauma
2
Q
3 main neuropathologic changes in AD
A
Senile plaques
Neurofibrillary tangles
Dystrophic neurites
3
Q
Senile plaques
A
Extracellular deposit of protein with properties of amyloid
Surrounded by ring of abnormal neuronal processes (dystrophic neurites)
Common in normal aging
SP alone do not equal dementia
4
Q
What allele is the highest inheritance risk for AD?
A
ApoE4
5
Q
Neurofibrillary tangles
A
Intraneural collections of abnormal protein fibrils Paired helical filaments Hyperphosphorylated tay protein Not specific for AD They might actually be protective
