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MSK, rheum, derm > pathophys > Flashcards

pathophys Flashcards

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Dermatology Board Prep flashcards
1
Q

what 5 joints does OA usually effect? gender predilection?

A
  • hands, PIP and DIP, CMC of thumb (women)
  • knees (women)
  • hips (men)
  • feet (MTP 1)
  • spine
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2
Q

what joints does OA secondary to DM neuropathy affect?

A

MTPs 2-5 also

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3
Q

what two genetic alleles predispose to RA?

A

HLA-DRB1

PTPN22

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4
Q

what antibodies are most specific to RA? what other antibodies are associated with RA?

A

anti-CCP

rheumatoid factor

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5
Q

what immune response is implicated in RA?

A

TH1 and TH17

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6
Q

which joints in the hand does RA affect? what joints may it affect that aren’t usually affected in OA?

A

MCP and PIP, not DIP

shoulder and ankle

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7
Q

what is different between the spinal involvement of OA and RA?

A

RA: only cervical spine with risk of spinal cord compression

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8
Q

what confers genetic predisposition to SLE?

A

HLA-DR2
HLA-DR3 weakly
C1q, C2 or C4 complement deficiency

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9
Q

which antibodies are specific to SLE and what are they associated with?

A

anti-dsDNA: nephritis
anti-SM: none
antiphospholipids: clotting, spontaneous abortions

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10
Q

what resembles RA but shows no erosions, deformities are reducible?

A

Jaccoud’s-like arthropathy: arthritis in SLE with history of rheumatic fever

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11
Q

what T cell response is seen in scleroderma?

A

TH2: alternative macrophage activation and collagen deposition

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12
Q

what suggests autoimmune etiology with Raynaud’s?

A

widened capillary loops in nail-bed

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13
Q

what antibodies are associated with diffuse SSc, limited SSc, and scleroderma renal crisis?

A

diffuse SSc: anti-topoisomerase 1 (anti-Scl70)
limited SSc: anti-centromere
renal crisis: anti-RNA polymerase III

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14
Q

what antibody is associated with overlap syndrome (SLE, scleroderma, MCTD)?

A

anti-U1-RNP

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15
Q

what is the most common cause of death in diffuse SSc?

A

interstitial lung disease, PAH

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16
Q

what is the clinical presentation of limited SSc

A 
CREST
calcinosis
Raynaud
esophageal dysmotility
sclerodactyly
telangiectasia
17
Q

what disease characteristics are seen in MCTD? what is the most common cause of death?

A

lupus, scleroderma, myositis

PAH

18
Q

what antibodies are somehwat sensitive but not specific to Sjogren’s? which are specific?

A

ANA and rheumatoid factor

anti-Ro (SSA) and -La (SSB)

19
Q

what is the negative predisposition for spondyloarthropathies?

A

HLA-B27

20
Q

how does reactive arthritis present? what is the genetic predisposition?

A

HLA-B27

  1. arthritis
  2. urethritis
  3. conjuncitivitis
21
Q

which specific cytokine is increased in psoriatic arthritis?

A

IL-18

22
Q

what disease is anti-Jo-1 antibody associated with?

A

polymyositis and dermatomyositis with arthritis

23
Q

what other organ is infected in 70% of inflammatory myopathies?

A

interstitial lung disease

24
Q

what should be tested for following diagnosis of inflammatory myositis, esp. dermatomyositis?

A

malignancy in 12%

25
Q

what inflammatory cells are implicated in DM vs PM/IBM?

A

DM: CD4, macros, dendritic cells

PM/IBM: CD8 and macros

26
Q

with arthritis, what differentiates the rashes of dermatomyositis and SLE?

A

DM rash affects knuckles, SLE spares knuckles and affects phalanges
DM doesn’t spare nasolabial folds

27
Q

what is cracking hyperkeratosis of skin over fingers with arthritis of those small joints a sign of?

A

dermatomyositis or polymyositis

28
Q

how can polymyositis be clinically differentiated from inclusion body myositis?

A

IBM is resistant to glucocorticoid treatment

29
Q

how can inflammatory myopathies and polymyalgia rheumatica be differentiated in lab?

A

myopathies: increased CPK
polymyalgia: elevated ESR

MSK, rheum, derm (6 decks)

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