Hereditary spherocytosis results from ___________.

a hereditary defect in spectrin, ankyrin, or band 3.1

Histologically, hereditary spherocytosis leads to __________.

blebs of membrane breaking off, loss of central pallor, and anisocytosis

The MCHC (mean corpuscular hemoglobin concentration) will be _______ in hereditary spherocytosis, uniquely.

increased, because the loss of membrane leads to decreased cell volume and resultant increase in hemoglobin concentration

Features of the past medical history common to hereditary spherocytosis include ___________.

splenomegaly, bilirubin gallstones, and aplastic anemia second to parvovirus B19

Hereditary spherocytosis can be tested by placing RBCs in ___________.

a hypotonic sucrose solution (osmotic fragility test)

Following splenectomy (or other splenic dysfunction), _________ will appear on blood smears.

Howell-Jolly bodies (pieces of DNA in RBCs that would normally be removed by the spleen)

HgbS precipitates in response to _________.

deoxygenation, acidosis, and dehydration (precipitation is reversible)

Sickle cell results in _________ hemolysis.

extravascular, due to weakening of the red cell membrane

Because sickle cell disease results in extravascular hemolysis, there will also be _________ in those with sickle cell, similar to hereditary spherocytosis.

bilirubin gallstones, jaundice, and splenomegaly

Pathoma: Normocytic Anemia with Extravascular Hemolysis Flashcards by Billy Tran

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Pathoma: Normocytic Anemia with Extravascular Hemolysis Flashcards

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