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Heme Onc 2 > Pathoma > Flashcards

Pathoma Flashcards

1
Q

Key differences between ALL and AML

A

AML: Auer rods
ALL: +Tdt (DNA polymerase)

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2
Q

Genetic condition associated with ALL after the age of 5 y/o

A

Down Syndrome

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3
Q

Difference in T-ALL and B-ALL cells

A

B: positive for 10, 19, 20
T: postive for CD2 thru 8, No 10

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4
Q

2 Diseases the the Philadelphia chromosome is associated with, gene it codes for, and major cause

A

B-ALL and CML, BCR-ABL gene, and radiation (Godzilla tears up Philly)

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5
Q

Translocation of Acute promyelocytic leukemia and gene codes for

A

t(15;17). RAR receptor. Use All-trans-retinoic acid to help the cells mature

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6
Q

What part of APL makes them more prone to DIC

A

the Auer rods activate the cascade

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7
Q

Heme cancer associated with hyperplasia of the gums

A

Acute monocytic leukemia

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8
Q

Only Acute myeloid leukemia that lacks MPO

A

Acute megakaryoblastic leukemia

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9
Q

Associated with AML ~before~ the age of 5

A

Acute megakaryoblastic leukemia

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10
Q

Key feature of Chronic Lymphocytic Leukemia

A

Naïve B cell proliferations, so co-express CD5 and CD20, Smudge cells

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11
Q

CDs associated with Hairy Cell Leukemia

A

CD103 and 123

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12
Q

Flower cells are seen in what leukemia?

A

Adult TLL

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13
Q

Rash, lytic bone lesions, and hypercalcemia

A

Adult TLL

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14
Q

Follicular lymphoma translocation and gene it codes for

A

t(14:18) and Bcr-l2 (L2 looks like LL…foLLIcular lymphoma)

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15
Q

Treatment for follicular lymphoma

A

CHOP-R (R=rituximab, against CD20)

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16
Q

Mantle Cell lymphoma translocation and gene

A

t(11:14) and Cyclin D1, that causes the cell to go from G1 to S phase

17
Q

Burkitt’s lymphoma translocation and gene

A

t(8;14) and c-myc to promote over expression of cell growth

18
Q

Diffuse Large B Cell Lymphoma translocation and gene

A

t(2;5) and ALK-1 OR no translocation. Can come from Follicular cell lymphoma. Very aggressive

19
Q

CD in Nodular Lymphocyte predominate HL

A

CD20 and CD45

20
Q

CD in Classical HL

A

CD30 and CD15

21
Q

High serum levels of IL-6 suggests what?

A

Multiple Myeloma

22
Q

What does multiple myeloma cause lytic bone lesions and hypercalcemia?

A

RANK activates osteoclasts, creating the signs seen.

23
Q

Most common IG in multiple myeloma?

A

M spike is typically IgG

24
Q

Rouleux chains are associated with what?

A

Multiple Myeloma

25
Q

Light chains excreted in urine

A

Bence-Jones proteins

26
Q

Waldenstroms Macroglobulinemia M spike is from what?

A

IgM over production with B cell lymphoma

27
Q

Histology of Langherhans Histocytosis

A

Birbeck granules. aka Tennis rackets, CD1a + and S100+

Heme Onc 2 (1 decks)

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